Hemosorption and Other Efferent Methods in Medicine

Abstract

S c i e n t i f i c R e s e a r c h I n s t i t u t e of Physico-Chemical M e d i c i n e M i n i s t r y of P u b l i c H e a l t h of t h e R u s s i a n F e d e r a t l o n , Moscow R e c i e v e d ; October 3, I Y M 6 ; R e v i s e d ; J a n u a r y 1 2 , l Y M 7 From t h e most a n c i e n t t i m e s p r a c t i c a l m e d i c i n e p o s s e s s e d two main methods of i n f l u e n c l n g a s i c k man: 1. i n t r o d u c i n g m e d i c i n e i n t o h i s i n t e r n a l media and 2. e v a c u a t i n g p o i s o n o u s o r s u p e r f l u o u s s u b s t a n c e s f r o m t h e body.e v e r y t h i n g t h a t l a c k s , and S u b t r a c t i o n of e v e r y t h i n g t h a t i s s u p e r f l u o u s .

The function of hemodialysis equipment in bioengineered systems for artificial clearance of blood

“…For example, disorders of the excretory function of kidneys (renal insufficiency) [5,[9][10][11] is accompanied by excessive hydration and excessive concentrations of sodium, potassium, urea, creatinine, uric acid, and other substances in blood. Without proper treatment (e.g., by artificial extracorporeal blood clearance, Fig.…”

“…5 performed using an artificial kidney apparatus. During more than half a century of use of the artificial kidney apparatus, its design has been improved and an independent branch of biomedical science and engineering concerned with the study, development, manufacture, and clinical use of equipment for hemodialysis has developed [6,[9][10][11]14].…”

“…In medical practice, artificial organs are used to assist malfunctioning natural organs to maintain a normal physiological state [4,[9][10][11]18]. Artificial clearance of blood based on extracorporeal perfusion is successfully used for intensive care in cases of acute intoxication caused by various diseases, postoperative complications, poisoning, injury, bum, incompatible blood transfusion, or radiation injuries and for long-term (15-20 years) life support of patients with chronic renal diseases by regular (2-3 times per week) blood clearance (the duration of each procedure is 4-5 h) [16][17][18].…”

“…To estimate the clinical efficacy of a biotechnical hemodialysis system, normalization of the concentration of electrolytes and low-and moderate-molecular-weight substances in blood and removal of excessive liquid caused by the hemodialysis procedure should be taken into account [9][10][11]14].…”

Prolonged bactericidal effect of sodium hypochlorite

“…The method of indirect electrochemical oxidation with sodium hypochlorite (NaOC1) is a perspective treatment. This agent is highly effective towards purulent surgical infection; it cancels antibiotic resistance of microorganisms; the effects of the majority of antibacterial drugs are potentiated by NaOCI; the exo-and endotoxins of pathogenic microorganisms can be bound by sodium hypochlorite [1,2,4]. However, NaOC1 is an unstable compound, and its therapeutic effect is limited by several minutes, after which it rapidly degrades.…”