Hemorrhagic polyneuropathy in idiopathic thrombocytopenic purpura

Hemorrhagic neuropathy associated with vasculitis

“…We read with great interest the recent case reported by Moon et al (2007) on a fulminant painful quadriplegia due to extensive intraneural bleeding in the setting of idiopathic thrombocytopenic purpura and hemorrhagic areas predominated in the endoneurium very close to the perineurium. Another case had impressive hemorrhagic areas in the perineurium, and nerve specimens had been taken from the amputated left leg after operation of an aortic dissection and intravenous administration of 30,000 units of heparin ( Korthals et al, 1994 ) .…”

“…Another case had impressive hemorrhagic areas in the perineurium, and nerve specimens had been taken from the amputated left leg after operation of an aortic dissection and intravenous administration of 30,000 units of heparin ( Korthals et al, 1994 ) . There are few reported cases of hemorrhagic polyneuropathy, and they were observed in bleeding disorders ( Moon et al, 2007 ) .…”

“…It was also reported in cases of microvasculitis ( Dyck et al, 1999 ) . Anyway, red cells are harmful for nerve fibers, and their presence inside degenerated nerve fibers has been nicely demonstrated ( Moon et al, 2007 ) . Up to now, hemorrhagic polyneuropathy has not been reported in a setting of vasculitis, and the case reported here was probably due to the rupture of an aneurysm located in the perineurium.…”