Hemorrhagic Lesions

Bigio, Marc R. Del

doi:10.1002/9781119013112.ch20

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…The ganglionic eminence (GE) is a transitory brain region which is the source of critical waves of cell proliferation and migration to the cortex, including a class of neocortical GABAergic interneurons 34 as well as neurons for the basal nuclei 35 . The GE regresses gradually 19 with final involution of the GE by 34–36 weeks 36 . Thus, infants are born prematurely retain the GE through birth and experience a portion of this involution ex utero.…”

Section: Discussionmentioning

confidence: 99%

Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage

Lin

Hagan

Fenoglio

et al. 2016

Sci Rep

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Low-grade germinal matrix-intraventricular hemorrhage (GM-IVH) is the most common complication in extremely premature neonates. The occurrence of GM-IVH is highly associated with hemodynamic instability in the premature brain, yet the long-term impact of low-grade GM-IVH on cerebral blood flow and neuronal health have not been fully investigated. We used an innovative combination of frequency-domain near infrared spectroscopy and diffuse correlation spectroscopy (FDNIRS-DCS) to measure cerebral oxygen saturation (SO2) and an index of cerebral blood flow (CBFi) at the infant’s bedside and compute an index of cerebral oxygen metabolism (CMRO2i). We enrolled twenty extremely low gestational age (ELGA) neonates (seven with low-grade GM-IVH) and monitored them weekly until they reached full-term equivalent age. During their hospital stay, we observed consistently lower CBFi and CMRO2i in ELGA neonates with low-grade GM-IVH compared to neonates without hemorrhages. Furthermore, lower CBFi and CMRO2i in the former group persists even after the resolution of the hemorrhage. In contrast, SO2 does not differ between groups. Thus, CBFi and CMRO2i may have better sensitivity than SO2 in detecting GM-IVH-related effects on infant brain development. FDNIRS-DCS methods may have clinical benefit for monitoring the evolution of GM-IVH, evaluating treatment response, and potentially predicting neurodevelopmental outcome.

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