Abstract:Sequelae following Nephropathia epidemica (NE) were investigated in 792 individuals living in an endemic area of Sweden. Volunteers were tested for presence of Puumala (PUU) virus specific IgG antibodies in serum, as well as several parameters linked with renal dysfunction and cardiovascular disease (systolic and diastolic blood pressure, ECG, BMI, total cholesterol and serum creatinine). No differences were seen in any of the variables tested between PUU virus antibody positive (n = 110) and negative individu… Show more
“…Due to the frequent occurrence of conspicuous renal failure in the acute phase of hemorrhagic fever with renal syndrome, a possible relation between passed hantavirus infection and the occurrence of chronic renal disease is of interest. Although some circumstantial evidence suggesting such an association has been presented (21-24), a study of 792 persons living in Sweden within an area endemic for nephropathia epidemica showed no difference between seropositive and seronegative persons in several parameters linked to renal dysfunction (25). Moreover, none of 62 patients showed renal sequelae in the follow-up 2 4 years after nephropathia epidemica (25), and, of 66 patients with nephropathia epidemica followed for 6 months after discharge from the hospital, none developed chronically impaired renal function (26).…”
Section: Discussionmentioning
confidence: 99%
“…Although some circumstantial evidence suggesting such an association has been presented (21-24), a study of 792 persons living in Sweden within an area endemic for nephropathia epidemica showed no difference between seropositive and seronegative persons in several parameters linked to renal dysfunction (25). Moreover, none of 62 patients showed renal sequelae in the follow-up 2 4 years after nephropathia epidemica (25), and, of 66 patients with nephropathia epidemica followed for 6 months after discharge from the hospital, none developed chronically impaired renal function (26). In agreement with these reports, our study showed no significant association between hypertension and the occurrence of antibodies to Puumala virus, and the results of the self-reports, and an analysis of hospital records, presented no evidence of chronic renal disease associated with nephropathia epidemica within the group of seropositive persons.…”
“…Due to the frequent occurrence of conspicuous renal failure in the acute phase of hemorrhagic fever with renal syndrome, a possible relation between passed hantavirus infection and the occurrence of chronic renal disease is of interest. Although some circumstantial evidence suggesting such an association has been presented (21-24), a study of 792 persons living in Sweden within an area endemic for nephropathia epidemica showed no difference between seropositive and seronegative persons in several parameters linked to renal dysfunction (25). Moreover, none of 62 patients showed renal sequelae in the follow-up 2 4 years after nephropathia epidemica (25), and, of 66 patients with nephropathia epidemica followed for 6 months after discharge from the hospital, none developed chronically impaired renal function (26).…”
Section: Discussionmentioning
confidence: 99%
“…Although some circumstantial evidence suggesting such an association has been presented (21-24), a study of 792 persons living in Sweden within an area endemic for nephropathia epidemica showed no difference between seropositive and seronegative persons in several parameters linked to renal dysfunction (25). Moreover, none of 62 patients showed renal sequelae in the follow-up 2 4 years after nephropathia epidemica (25), and, of 66 patients with nephropathia epidemica followed for 6 months after discharge from the hospital, none developed chronically impaired renal function (26). In agreement with these reports, our study showed no significant association between hypertension and the occurrence of antibodies to Puumala virus, and the results of the self-reports, and an analysis of hospital records, presented no evidence of chronic renal disease associated with nephropathia epidemica within the group of seropositive persons.…”
“…Pulmonary function testing reveals persistent defects in carbon monoxide diffusing capacity for up to 1 year and in small airways expiratory flow rates for up to 3 years or more for each of these three viruses, but resolution of symptoms may occur during persistence of the measured deficits. Appearance of proteinuria alone more than 3 years after recovery from SNV infection has been repeatedly documented (Goade, D. unpublished data), contrasting with persistence of urine concentrating capacity, but not proteinuria, for years after HTN and PUU infection (Rubini et al, 1960;Niklasson et al, 1994).…”
“…However, subsequent studies have not demonstrated such an association for Puumala in the Netherlands or Sweden [86,98] nor for Seoul or Sin Nombre viruses in Pima Indians [99].…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.