Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006–2014

Ling, Wang; Wang, Tao; Cui, Feng; Zhai, Shen Yong; Yang, Shuhu; Wang, Zhi Qiang; Yu, Xue Jie

doi:10.3201/eid2202.151516

Cited by 21 publications

(21 citation statements)

References 9 publications

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“…With equal emphasis on rodent control and immunization, the incidence of HFRS was at a low level between 2007 and 2012. The incidence of HFRS increased slightly in 2013 and gradually decreased in later years, which was consistent with the epidemic trend for reported HFRS cases nationwide . This corresponds to characteristics of periodic epidemics for diseases with a natural infectious focus of infection.…”

Section: Discussionsupporting

confidence: 83%

Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001‐2016

Cai

Wei

Han

et al. 2018

Journal of Medical Virology

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Hemorrhagic fever with renal syndrome (HFRS) is highly endemic in China, where approximately 90% of the total human cases in the world are reported. The Hebei province, one of areas with the highest prevalence, has reported HFRS cases every year in the last two decades. This study describes the spatiotemporal patterns of HFRS in the Hebei province from 2001 to 2016, detects the high-risk spatiotemporal clusters of HFRS, and provides valuable information for planning and implementation of local preventive measures. For the purpose of the analysis, HFRS cases recorded during the sixteen years in the Hebei province were aggregated into three temporal periods (2001-2006, 2007-2012, and 2013-2016). Spatiotemporal analyses, including Global spatial autocorrelation analysis and Kulldorff's scan statistical analysis, were applied to analyze te spatiotemporal clusters of HFRS at the county level. The results revealed that the spatial extent of the HFRS epidemic in the Hebei province changed dynamically from 2001 to 2016, which indicated that a comprehensive preventative strategy should be implemented in the northeastern regions of the Hebei province in spring.

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Section: Discussionsupporting

confidence: 83%

Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001‐2016

Cai

Wei

Han

et al. 2018

Journal of Medical Virology

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“…Here, we found that the annual average incidence was 2.45/10 5 during 2007–2015, with a peak of 3.54/10 5 in 2012, while this incidence was 0.83/10 5 in China during 2006–2012. 9 HFRS peaks once a year in the fourth quarter in Qingdao but twice a year in Zibo (36°47′N118°3′E), 13 an inland city located at the northwest of Qingdao with a straight-line distance of 283 km. The dual peaks of HFRS each year in Zibo was proved to be associated with the existence of HTNV and SEOV.…”

Section: Discussionmentioning

confidence: 99%

Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years’ longitudinal study

Jiang

Wang

et al. 2017

Emerging Microbes & Infections

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The incidence of hemorrhagic fever with renal syndrome (HFRS) in Qingdao, China was three times higher than that of the average national level. Here we characterized the epidemiology, ecological determinants and pathogen evolution of HFRS in Qingdao during 2007–2015. In this longitudinal study, a total of 1846 HFRS patients and 41 HFRS-related deaths were reported. HFRS in Qingdao peaked once a year in the fourth quarter. We built a time series generalized additive model, and found that meteorological factors in the previous quarter could accurately predict HFRS occurrence. To explore how meteorological factors influenced the epidemic of HFRS, we analyzed the relationship between meteorological factors and hantavirus-carrying states of the hosts (including rodents and shrews). Comprehensive analysis showed humidity was correlated to high host densities in the third quarter and high hantavirus-carrying rates of animal hosts in the third to fourth quarters, which might contribute to HFRS peak in the fourth quarter. We further compared the L segments of hantaviruses from HFRS patients, animal hosts and ectoparasites. Phylogenetic analysis showed that hantaviruses in gamasid and trombiculid mites were the same as those from the hosts. This indicated mites also contributed to the transmission of hantavirus. Furthermore, Hantaan virus from HFRS patients, hosts and mites in Qingdao formed a distinct phylogenetic cluster. A new clade of Seoul virus was also identified in the hosts. Overall, meteorological factors increase HFRS incidence possibly via facilitating hosts’ reproduction and consequent mite-mediated hantavirus transmission. New hantavirus subtypes evolved in Qingdao represent new challenges of fighting against HFRS.

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“…Previously, in the rural population of two prefecture-level cities (Zibo and Qingdao) of China, we found HFRS had a high incidence rate which ranged from 1.96 cases/100,000 persons to 28.9/100,000 in different years [10,11]. These studies indicated HFRS was epidemic in these areas.…”

Section: Introductionmentioning

confidence: 79%

“…These studies indicated HFRS was epidemic in these areas. Peridomestic rodents were also captured for orthohantavirus detection in the two cities and orthohantavirus antigens were found by immunofluorescence assay in 5.2% (29/559) and 3.8% (9/240) of these rodents, respectively [10,11], and the seropositive rate to hantavirus of host animals was as high as 23.3% [12]. Hantaan orthohantavirus (HTNV) and Seoul orthohantavirus (SEOV) are the causative agents of HFRS in these areas.…”

Section: Introductionmentioning

confidence: 99%

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

Sun

Qin

et al. 2019

Viruses

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The pathogenicity of the shrew-borne Imjin virus (MJNV) is unknown. The objective of our study was to find serological evidence of MJNV infection in humans. Partial MJNV nucleocapsid protein (NP) was cloned and expressed as an antigen for double-antigen sandwich ELISA, IgM capture ELISA, and dot blot to detect MJNV specific antibodies in hemorrhagic fever with renal syndrome (HFRS) patients’ and healthy persons’ sera from endemic areas in China. The purified recombinant NP reacted with neither the 90 healthy individuals’ sera from non-endemic areas of MJNV nor the 100 antisera to HFRS-causing virus, indicating that the MJNV NP had no cross-reaction with normal human sera and HFRS-causing viral antibodies. As determined by screening ELISA and dot blot analysis, IgG antibodies against MJNV NP were detected in sera from two of 385 healthy individuals from MJNV-endemic areas, suggesting infection with MJNV or MJNV-like thottimvirus. Based on the suggestive evidence, healthcare workers should be alert to febrile diseases occurring among individuals with exposure to shrew-infested habitats.

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Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006–2014

Cited by 21 publications

References 9 publications

Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001‐2016

Spatiotemporal patterns of hemorrhagic fever with renal syndrome in Hebei Province, China, 2001‐2016

Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years’ longitudinal study

Suggestive Serological Evidence of Infection with Shrew-Borne Imjin Virus (Hantaviridae) in Humans

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