Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Klempa, Boris; Ткаченко, Е. А.; Dzagurova, Tamara K.; Yunicheva, Yulia V.; Морозов, В. Г.; Okulova, N. M.; Slyusareva, Galina P.; Smirnov, Alexander; Krüger, Detlev H.

doi:10.3201/eid1404.071310

Cited by 105 publications

(107 citation statements)

References 30 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In European Russia and Europe, although the DOBV strains from different Apodemus hosts share high amino acid sequence similarity, they can be distinguished in phylogenetic analyses as distinct lineages and seem to possess different virulence in humans as well as in an animal model [12]. The novel DOBV-Ap lineage associated with A. ponticus, emerging in an area south of European Russia, confirms the reputation of DOBV as being the most virulent of the European hantaviruses [11]. Rather unusually for hantaviruses, DOBV has already been found in three different Apodemus species.…”

Section: )mentioning

confidence: 60%

“…Strains from central Europe and central European Russia form the DOBV-Aa lineage, which is distinct from the Saaremaa strains from northeastern Europe [9,10]. In southern Russia (Sochi district), a new DOBV variant (DOBV-Ap) found in A. ponticus, a novel hantavirus natural host, was identified as the causative agent of HFRS [11,42]. In European Russia and Europe, although the DOBV strains from different Apodemus hosts share high amino acid sequence similarity, they can be distinguished in phylogenetic analyses as distinct lineages and seem to possess different virulence in humans as well as in an animal model [12].…”

Section: )mentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

et al. 2009

Self Cite

View full text Add to dashboard Cite

ABSTRACT. European Russia is a highly endemic area of hemorrhagic fever with renal syndrome (HFRS), a rodent-borne zoonotic disease, caused by hantaviruses. In total, 145 small mammals of four species (Myodes glareolus, Apodemus flavicollis, A. agrarius, and A. uralensis) were trapped in the Samara region of European Russia in August 2005 and examined for the presence of hantavirus (HV). Anti-HV antibodies were found in six of 68 (8.8%) M. glareolus and in one of 19 (5.3%) A. flavicollis by indirect immunofluorescent antibody assay (IFA). The Puumala virus (PUUV), which is one of the hantavirus species, was detected in the lungs of seven M. glareolus by RT-PCR. The virus S-segment was extremely similar (96.2% to 99.3%) to the sequence found in a fatal case of HFRS in the Samara region. Phylogenetic analyses of S and M segments showed that the Samara PUUVs form a cluster within the Russian Volga lineage and apparently differ from other European PUUVs. Anti-PUUV antibodies were found in blood sera from seven HFRS patients and from one undiagnosed patient from the Samara region, using IFA and an enzyme-linked immunosorbent assay (ELISA). These data suggest that the bank vole M. glareolus is a primary natural reservoir and vector for PUUV, which is the main causative agent of HFRS in humans in the Samara region.KEY WORDS: epidemiology, hantavirus, hemorrhagic fever with renal syndrome, Puumala virus, rodents.J. Vet. Med. Sci. 71(12): 1569-1578, 2009 Hantaviruses belong to the genus Hantavirus, within the family Bunyaviridae, and cause two forms of human illness. These zoonoses include hemorrhagic fever with renal syndrome (HFRS), which occurs in Asia and Europe and is caused by the Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), Dobrava-Belgrade virus (DOBV), and Amur virus (AMRV). The second form of illness is hantavirus (cardio) pulmonary syndrome (HPS), which occurs in the Americas and is caused by the Sin Nombre virus, Andes virus, and other hantaviruses [13,28,33]. Hantaviruses are transmitted by aerosolized excreta from their natural hosts, mainly rodents of the family Muridae. Particular hantavirus species are usually harbored by a single rodent species, or by a few closely related rodent species, which indicates co-evolution and co-speciation of hantaviruses with their hosts. The virus genome contains three segments of negative-stranded RNA: the large (L) segment encodes a viral RNA-dependent RNA polymerase, the medium (M) segment encodes a glycoprotein precursor, and the small (S) segment encodes a nucleocapsid protein (NP) [34].In

show abstract

Section: )mentioning

confidence: 60%

Section: )mentioning

confidence: 99%

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…The prototype of DOBV is known as DOBV-Af, as it is associated with Apodemus flavicollis. A DOBV variant, Sochi subtype, known as DOBV-Ap (associated with Apodemus ponticus) causes severe human infection in the Black Sea coast region of Russia (Klempa et al, 2008). Another DOBV-like virus, referred to as SAAV or DOBV-Aa, was recovered from Apodemus agrarius on the Saaremaa island of Estonia (Papa, 2012).…”

Section: European Countriesmentioning

confidence: 99%

Hantavirus infection: a global zoonotic challenge

et al. 2017

View full text Add to dashboard Cite

Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide.

show abstract

“…6 Turkey has reported an outbreak of hantavirus infection from the Black Sea region in 2009. 7 Additionally, emergence of CCHF in southwest Russia and Turkey has been observed in the recent years. 8 The first reports of CCHF and hantavirus cases from Georgia were published by our team in 2009.…”

mentioning

confidence: 99%

Viral Hemorrhagic Fever Cases in the Country of Georgia: Acute Febrile Illness Surveillance Study Results

Kuchuloria

Imnadze

Chokheli

et al. 2014

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Minimal information is available on the incidence of Crimean-Congo hemorrhagic fever (CCHF) virus and hantavirus infections in Georgia. From 2008 to 2011, 537 patients with fever 38 C for 48 hours without a diagnosis were enrolled into a sentinel surveillance study to investigate the incidence of nine pathogens, including CCHF virus and hantavirus. Of 14 patients with a hemorrhagic fever syndrome, 3 patients tested positive for CCHF virus immunoglobulin M (IgM) antibodies. Two of the patients enrolled in the study had acute renal failure. These 2 of 537 enrolled patients were the only patients in the study positive for hantavirus IgM antibodies. These results suggest that CCHF virus and hantavirus are contributing causes of acute febrile syndromes of infectious origin in Georgia. These findings support introduction of critical diagnostic approaches and confirm the need for additional surveillance in Georgia.

show abstract

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Cited by 105 publications

References 30 publications

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

Hantavirus infection: a global zoonotic challenge

Viral Hemorrhagic Fever Cases in the Country of Georgia: Acute Febrile Illness Surveillance Study Results

Contact Info

Product

Resources

About