Hemorrhagic cystitis due to herpes simplex virus as a marker of disseminated herpes infection

DeHertogh, Deborah; Brettman, Lee R.

doi:10.1016/0002-9343(88)90148-9

Cited by 21 publications

(5 citation statements)

References 15 publications

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“…This study did not indicate that unrelated transplants are associated with a greater incidence of HC than matched related transplants, or stem cell source as bone marrow compared to peripheral blood, unlike a similar previous study [23]. Polyomavirus (BK or JC virus) is most commonly attributed to HC, whereas patients were less often infected by adenovirus and herpes virus [24][25][26]. The immune control of BK virus infection depends on both CD4 + and CD8 + T-cells [27].…”

Section: Discussioncontrasting

confidence: 60%

Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

et al. 2017

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Background Haemorrhagic cystitis (HC) is usually a serious complication in allogeneic haematopoietic stem cell transplantation (allo-HSCT) recipients. In this study, our aim was to define risk factors and outcomes for patients with HC in an allo-HSCT setting. Methods We retrospectively evaluated 249 allo-HSCTs performed between 2011 and 2016 in our centre. Results HC was diagnosed in 98 patients (39%) at a median of 119 days (range 5–580) and 91 (93%) of the patients had late onset disease. In univariate analysis, HC was related to cytomegalovirus (CMV) reactivation (P<0.001) and BK viraemia (P<0.001); in multivariate analysis, the presence of CMV reactivation was determined to be an independent risk factor (odds ratio: 22.1; 95% CI 1.73, 282.44; P=0.017). There was no association detected between acute graft versus host disease and patients diagnosed with HC within 100 days of transplant. HC was significantly increased by the presence of myelo-ablative conditioning (odds ratio: 31.28; 95% CI 3.98, 246.87; P=0.001) and BK viraemia (odds ratio: 3.93; 95% Cl 1.10, 14.05; P=0.035) in patients with HC grade II and beyond. Forced hydration was recommended in all patients with grade I HC. Patients with HC and clots were treated with continuous bladder irrigation, and 14 of 44 patients with BK viraemia received cidofovir ± ribavirin. Eight of these patients (57%) responded to treatment. Refractory HC was detected in 17 patients (17%) and resolved by a variety of procedures. Conclusions This study suggests that CMV reactivation is associated with increased risk of HC in multivariate analysis, however, this result is not confirmed in patients with HC grade II and beyond.

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Section: Discussioncontrasting

confidence: 60%

Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

et al. 2017

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“…2,14,[26][27][28] Although HC can be secondary to a variety of factors (drugs, radiation, infections), HC in the BMT setting is usually either related to the use of CY or, later in the course of the transplant, to viral infections. [2][3][4][5][6][7][8]14 CY has been widely used for conditioning patients for BMT. Methods commonly used for prophylaxis of HC in BMT patients are intravenous hyperhydration (IVH), continuous bladder irrigation (CBI) and, more recently Mesna.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for severe hemorrhagic cystitis following BMT

Seber

Shu

DeFor

et al. 1998

Bone Marrow Transplant

155

137

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Summary:Hemorrhagic cystitis (HC) is a common toxicity of preparative regimens for bone marrow transplantation (BMT). Severe HC often requires prolonged and expensive hospitalization, and occasionally can result in death. To investigate the risk factors for severe HC, we conducted a retrospective study among 1908 patients who received BMTs at the University of Minnesota during 1974 to 1993. A previous report from our institution reported on 977 of these patients. We identified all patients with genitourinary complication within 100 days post-BMT from the BMT database. Medical charts for these patients were reviewed to determine whether the patient had HC and also the grade of HC. A total of 208 HC cases were identified during the study period. Of them, 92 patients had severe HC, an incidence of 5% (95% CI = 4-6%). We found that grade II-IV graftversus-host disease (RR = 2.56; 95% CI = 1.43-4.56), use of busulfan (RR = 2.69; 95% CI = 1.35-5.35), and age at transplant (RR = 2.20; 95% CI = 1.27-3.81, for age of 10-30 compared to age of 0-9) were related to an increased risk of HC. In contrast, transplant year was inversely associated with the risk of HC (trend test, P Ͻ 0.01). We did not find any significant difference in HC with the use of prophylactic Mesna. Keywords: bone marrow transplantation; complications; hemorrhagic cystitis; risk factors; adenovirus; cytomegalovirus Outcome after bone marrow transplantation (BMT) has improved over the past 20 years, 1 but preparative regimenrelated toxicities (RRT) remain a major limitation to further progress. Hemorrhagic cystitis (HC) is a common RRT. 2 In the BMT setting, HC occurring in the early post-transplant period is more frequently associated with the use of cyclophosphamide (CY), while late occurring HC frequently results from viral infections (eg BK virus, adenovirus type II). 3-8 CY has been widely used for conditioning patients undergoing BMT. The drug is hydroxylated in the liver, generating 4 hydroxy-CY, phosphoramide mustard, and acrolein. Excreted in the urine, acrolein can cause edema,

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“…Polyomavirus (BK and JC virus) in particular, and less commonly adenovirus and herpes simplex virus can cause HC after hematopoietic transplantation. [8][9][10] CMV-induced HC should be recognized as another life-threatening complication of hematopoietic stem cell transplantation. Although rare, recognition and early diagnosis of this entity may reduce the mortality associated with CMV disease after stem cell transplantation.…”

mentioning

confidence: 99%

CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report

Tutuncuoglu

Yanovich

Özdemirli

2005

Bone Marrow Transplant

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Hemorrhagic cystitis due to herpes simplex virus as a marker of disseminated herpes infection

Cited by 21 publications

References 15 publications

Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?

Risk factors for severe hemorrhagic cystitis following BMT

CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report

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