Hemorrhagic Coagulation Disorders and Ischemic Stroke: How to Reconcile Both?

Abstract

Coagulation and fibrinolytic system disorders are conditions in which the blood’s ability to clot is impaired, resulting in an increased risk of thrombosis or bleeding. Although these disorders are the expression of two opposing tendencies, they can often be associated with or be a consequence of each other, contributing to making the prognosis of acute cerebrovascular events more difficult. It is important to recognize those conditions that are characterized by dual alterations in the coagulation and fibrinolytic systems to reduce the prognostic impact of clinical conditions with difficult treatment and often unfortunate outcomes. Management of these individuals can be challenging, as clinicians must balance the need to prevent bleeding episodes with the potential risk of clot formation. Treatment decisions should be made on an individual basis, considering the specific bleeding disorder, its severity, and the patient’s general medical condition. This review aims to deal with all those forms in which coagulation and fibrinolysis represent two sides of the same media in the correct management of patients with acute neurological syndrome. Precision medicine, personalized treatment, advanced anticoagulant strategies, and innovations in bleeding control represent future directions in the management of these complex pathologies in which stroke can be the evolution of two different acute events or be the first manifestation of an occult or unknown underlying pathology.

The association of the platelet/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study

“…Research by Jialal et al [ 20 ] demonstrated a significant correlation between the PHR and elevated triglycerides and coagulation factors, suggesting that an elevated PHR may reflect an imbalance in coagulation homeostasis. Ischemic stroke patients often exhibit coagulation abnormalities, with post-stroke complications frequently related to coagulation dysfunction [ 44 ]. In the current study, the PHR showed a linear positive correlation with cardiovascular-specific mortality among stroke survivors.…”