Hemorrhagic Cholecystitis: A Rare Cause of Melena

Abstract

Hemorrhagic cholecystitis --a rare cause of hemobilia and melena --is an atypical presentation of calculous cholecystitis, associated with significant morbidity and mortality. A 75-year-old woman with multiple comorbidities, who was undergoing dual antiplatelet therapy, presented with symptoms of acute cholecystitis. Two days later, she developed melena and symptoms of obstructive jaundice. Following radiological evaluation, a diagnosis of hemorrhagic cholecystitis was made. The patient was managed conservatively with IV antibiotics and blood transfusion in the initial period (clopidogrel was withheld); an interval cholecystectomy was performed six weeks later. Hemorrhagic cholecystitis is a rare complication of acute cholecystitis, and its diagnosis is challenging as it mimics various other hepatopancreaticobiliary diseases. Management options include early surgery or conservative management at the initial stage, followed by interval cholecystectomy.

Hemorrhagic Necrotizing Cholecystitis With Cholecystocolonic Fistula: A Case Report

“…Hemorrhagic cholecystitis clinically manifests with right upper quadrant pain, positive Murphy’s sign, impaired liver function, and leukocytosis [ 14 , 15 ]. Haemobilia, jaundice, and melena have also been documented as uncommon presentations [ 15 , 16 ]. Transmural inflammation causes mural necrosis and ulceration, followed by hemorrhage into the gallbladder lumen.…”