Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage

Gutiérrez, José Marı́a; Rucavado, Alexandra; Escalante, Teresa; Díaz, Cecilia

doi:10.1016/j.toxicon.2005.02.029

Cited by 399 publications

(282 citation statements)

References 103 publications

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“…The protease proteome includes several major families, with matrix metalloproteases being the most prominent. Matrix metalloproteases can activate toxins or act as toxins themselves (33). In addition, they are essential factors in ECM remodeling and tissue morphogenesis.…”

Section: Resultsmentioning

confidence: 99%

Proteome of Hydra Nematocyst

Balasubramanian

Beckmann

Warnken

et al. 2012

Journal of Biological Chemistry

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Background: Nematocysts are the most sophisticated organelles in the animal kingdom and a hallmark of the phylum Cnidaria.Results: We present the first complete protein map of the Hydra nematocyst. Conclusion:The nematocyst proteome is highly complex and includes novel structural proteins. Significance: The proteome data reveal a eukaryotic origin of the nematocyst and point to common molecular features with the extracellular matrix.

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Section: Resultsmentioning

confidence: 99%

Proteome of Hydra Nematocyst

Balasubramanian

Beckmann

Warnken

et al. 2012

Journal of Biological Chemistry

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“…NOS inhibition promotes an increase in blood pressure which, in turn, may contribute to capillary wall rupture after degradation of basement membrane components by venom hemorrhagic metalloproteinases. Accordingly, it has been proposed that biophysical forces operating in the microvasculature in vivo are likely to participate in the mechanism of venom metalloproteinase-induced hemorrhage [41]. Differences in the effect of NO on the microvasculature of skin and skeletal muscle may explain the differences observed in the two experimental systems.…”

Section: Discussionmentioning

confidence: 99%

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

2006

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Abstract.Objective: To assess the role of nitric oxide in the most relevant local and systemic manifestations in mice injected with the venom of the snake Bothrops asper. Mice were pretreated with nitric oxide synthase inhibitors, and the modifi cations of the pathological effects induced by the venom were tested. Results: Inhibition of NO synthesis did not affect acute local myonecrosis and hemorrhage in muscle tissue upon intramuscular injection of venom. Local footpad edema was reduced in mice pretreated with the NO synthase inhibitor L-NAME, and a reduction in the extent of infl ammatory infi ltrate in muscle tissue was observed after envenomation in mice pretreated with L-NAME and aminoguanidine. The most pronounced effect of NOS inhibition by L-NAME was an increment in the lethal activity of the venom, when injected by the intraperitoneal route. Conclusion: Nitric oxide does not seem to play a signifi cant role in the local acute pathological alterations (hemorrhage and myonecrosis) induced by B. asper venom in mice, although it contributes to edema and infl ammatory infi ltrate. Nitric oxide exerts a protective role in the systemic pathophysiological manifestations leading to lethality.

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“…This specimen has shown a wide range of biological activities, such as hemorrhagic fibrinogenolytic degradation of components in the extracellular matrix, and activation of prothrombin and factor X, resulting in extensive local tissue damage and systemic bleeding (12,13).…”

Section: Discussionmentioning

confidence: 99%

Envenomation caused by the bite of the snake Bothriechis schlegelii. Report of two cases in Colombia

Ruiz¹

2017

Case reports

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La mordedura de serpiente del género Bothriechis es frecuente en regiones de Colombia como el eje cafetero. Debido a sus costumbres arborícolas y su actitud defensiva, por lo general estas serpientes muerden a agricultores en sus miembros superiores y rostro. En Colombia, la incidencia de accidentes provocados por este tipo de serpiente aún no ha sido estimada con exactitud, ya que existen deficiencias en el registro de los mismos, así como desconocimiento de este reptil por parte del personal de salud que trabaja en su área de influencia. En este artículo se presentan dos casos de mordeduras por B. schlegelii ocurridos en Colombia en 2015. El primero, un hombre de 55 años con mordedura en mano izquierda, que desarrolló parestesias y edema hasta antebrazo sin otros hallazgos y que fue sometido a tratamiento con antivipérido polivalente de Probiol®, con resolución completa del evento. Por su parte, el segundo caso es el de un hombre de 62 años que fue mordido en mano izquierda, presentando emesis, diaforesis, edema hasta el hombro y tiempos de coagulación prolongados, sin sangrado; el paciente requirió ocho ampollas de antivipérido polivalente del Instituto Nacional de Salud (Colombia), con lo que se logró normalización de tiempos de coagulación y resolución completa del evento.

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Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage

Cited by 399 publications

References 103 publications

Proteome of Hydra Nematocyst

Proteome of Hydra Nematocyst

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

Envenomation caused by the bite of the snake Bothriechis schlegelii. Report of two cases in Colombia

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