Hemorheological Study in Patients with Coronary Artery Disease

M, Mares; Bertolo, Corrado; Terribile, V; Girolami, Antonio

doi:10.1159/000174774

Cited by 13 publications

(4 citation statements)

References 8 publications

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“… 28 – 30 Mares et al evaluated the role of the blood viscosity in patients with ischemic heart disease and found that high viscosity is an independent predictor of both in-hospital and long-term adverse outcomes. 31 Blood viscosity is also a risk factor in cardiovascular events. 32 …”

Section: Discussionmentioning

confidence: 99%

The relationship between eosinophilia and slow coronary flow

Altaş¹,

Kurtoğlu²,

Yaylak³

et al. 2015

TCRM

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AimThe pathophysiology of slow coronary flow (SCF) involves atherosclerosis, small vessel dysfunction, platelet function disorders, and inflammation. It has been known that eosinophils also play a significant role in inflammation, vasoconstriction, thrombosis, and endothelial dysfunction. We propose to evaluate the relationship between eosinophilia and SCF.MethodsAll patients who underwent coronary angiography between January 2011 and December 2013 were screened retrospectively. Of 6,832 patients, 102 patients with SCF (66 males, mean age 52.2±11.7 years) and 77 control subjects with normal coronary angiography (50 males, mean age 50.7±8.1 years) were detected. Baseline characteristics, hematological test results, and biochemical test results were obtained from the hospital database.ResultsBaseline characteristics of the study groups were comparable between groups. There was no significant difference between groups regarding leukocyte count, paletelet count, and mean platelet volume. However, patients with SCF had a higher eosinophil count than the controls (0.24±0.17×103/μL vs 0.16±0.15×103/μL, P=0.002). In addition, eosinophil count was found to be correlated with thrombolysis in myocardial infarction (TIMI) frame count in the SCF group (r=0.3, P<0.01). There was no significant correlation between eosinophil count and the number of coronary arteries showing slow flow.ConclusionPatients with SCF have higher blood eosinophil count, and this may play an important role in the pathogenesis of SCF. Elevated baseline eosinophil count may indicate the presence of SCF.

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Section: Discussionmentioning

confidence: 99%

The relationship between eosinophilia and slow coronary flow

Altaş¹,

Kurtoğlu²,

Yaylak³

et al. 2015

TCRM

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“…The knowledge of deformation and stress of cell is of great importance by various physiological and pathological parameters, such as temperature, morphology, osmotic pressure, ATP effect, parasite invasion, genetic diseases (e.g., sickle cell anaemia). 16 Erythrocyte deformability also becomes altered in other diseases such as diabetes mellitus, 17-21 essential hypertension, [22][23][24][25][26] arteriosclerosis, coronary artery disease 27,28 and cancer. 29 The shear modulus in this study can be employed to nd the shape of a spherical particle submerged in a horizontal ow of a liquid.…”

Section: Discussionmentioning

confidence: 99%

Elastic theory for the deformation of a spherical dielectric biological object under electro-optical trapping

Haque¹

2015

RSC Adv.

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“…There is considerable epidemiological evidence indicating that there is a higher incidence of myocardial infarctions, strokes, and sudden cardiac death in man in the morning (Marshall 1977, Muller et al 1985, 1987. There is also evidence of higher viscosity in patients with high blood pressure, coronary heart disease and stroke (Parfenov & Belousov 1989, Leschke et al 1990, Koenig et al 1991, Mares et al 1991. It has also M .…”

Section: Discussionmentioning

confidence: 99%

Morning increase in whole blood viscosity: a consequence of a homeostatic nocturnal haemodynamic pattern

Talan

Engel

1993

Acta Physiologica Scandinavica

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In a series of studies, we have shown that in non-human primates there is a consistent overnight fall in cardiac output and central venous pressure, and a rise in total peripheral resistance. This haemodynamic pattern is associated with a higher haematocrit level in the morning suggesting that these changes in the circulation are homeostatic adjustments to a nighttime fall in plasma volume. The present study was designed to test the hypothesis that in the morning whole blood viscosity also is higher. Whole blood viscosity was measured at shear rates of 450, 225, 90, 45, and 22.5 s-1 in each of six monkeys, on four occasions, at 2-week intervals, at 17.00 and 09.00 h the next morning. The average haematocrit was 4.2% higher in the morning than in the previous evening (P < 0.01). Viscosity decreased monotonically at progressively higher shear rates but was always significantly higher in the morning than in the evening (P < 0.01 at all shear rates). When viscosity was adjusted by covarying for haematocrit level, the morning/evening differences became non-significant. However, the morning/evening differences in linear trend of shear stress as a function of shear rate persisted. These findings add further support to our hypothesis that the nocturnal haemodynamic pattern in non-human primates is related to a reduction in plasma volume, and they also suggest that the morning rise in haematocrit is a major contributing factor to the elevated viscosity.

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Hemorheological Study in Patients with Coronary Artery Disease

Cited by 13 publications

References 8 publications

The relationship between eosinophilia and slow coronary flow

The relationship between eosinophilia and slow coronary flow

Elastic theory for the deformation of a spherical dielectric biological object under electro-optical trapping

Morning increase in whole blood viscosity: a consequence of a homeostatic nocturnal haemodynamic pattern

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