Hemorheological and Microcirculatory Relations of Acute Pancreatitis

Kotán, Róbert; Pető, Károly; Deák, Ádám; Szentkereszty, Zsolt; Németh, Norbert

doi:10.3390/metabo13010004

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…In this study, the physiological metabotype created was able to distinguish between the mild and the severe groups of patients. AP patients undergo a hypermetabolic condition, which dysregulates amino acid, lipid, and glucose metabolism (Kotan et al, 2023). Metabolites such as lactate, phenylalanine, mannose, and acetoacetate, and 3-HB increased in concentration while ascorbate, methanol, ethanol, and glutamine reduced with AP severity in this cohort.…”

Section: Discussionmentioning

confidence: 99%

Metabolites and lipoproteins may predict the severity of early Acute Pancreatitis in a South African cohort

Mazibuko,

Elebo,

Williams

et al. 2023

Preprint

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BackgroundAcute pancreatitis (AP) is a common clinical disease with varying severity. The Revised Atlanta Classification (RAC) categorises AP into mild, moderately severe, and severe (MAP, MSAP and SAP) respectively. Despite the availability of different scoring systems to triage patients, these are not always suitable for predicting the course and outcome of certain patients during admission. In this study, untargeted metabolomics was used to identify metabolic parameters that can potentially be used as prognostic markers for stratifying the risk profiles of patients for improved management and treatment.MethodsSerum isolated from blood samples collected from 30 AP patients (8 MAP, 14 MSAP, and 8 SAP) and 9 healthy control (HC) individuals was analysed using1H nuclear magnetic resonance (NMR) spectroscopy. Wilcoxon and Kruskal–Walli’s rank-sum tests were used to compare differences in numerical covariates. A liposcale test was used for lipoprotein characterization and the Spearman rank test was conducted for correlation of the data. P-values < 0.05 were considered significant.ResultsElevated levels of lactate, (rho = 0.67; p-value < 0.001, FDR = 0.001), 3-hydroxybutyrate (rho = 0.46; p-value < 0.003, FDR = 0.013), acetoacetate (rho = 0.63; p-value < 0.001, FDR < 0.001) and lipid alpha-CH2 (rho = 0.45; p-value = 0.004, FDR = 0.013) were associated with AP severity as was decreased levels of ascorbate (rho = 0.46; p-value < 0.003, FDR = 0.013), methanol (rho = 0.46; p-value < 0.003, FDR = 0.013), glutamine (rho = -0.55; p-value < 0.001, FDR = 0.002), ethanol (rho = 0.64; p-value < 0.001, FDR< 0.001), protein-NH (rho= -0.75; p-value < 0.001, FDR<0.001) among others. HDL-C decreased while IDL-C and VLDL-C increased across all the AP metabolic phenotypes compared to the HC.ConclusionDysregulated metabolites and lipids can potentially add to the understanding of the pathophysiological conditions of AP and can aid in the early prognosis and stratification of patients for specialist care.

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Section: Discussionmentioning

confidence: 99%

Metabolites and lipoproteins may predict the severity of early Acute Pancreatitis in a South African cohort

Mazibuko,

Elebo,

Williams

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, the release of certain inflammatory mediators such as nitric oxide is inhibited, leading to a decrease in vascular relaxation function and reduced vascular tension ( Neumann et al, 2004 ). The presence of inflammatory mediators can also increase plasma viscosity, red blood cell aggregation and platelet activation, leading to an increase in blood flow resistance and a decrease in microcirculatory perfusion, subsequently affecting the normal function of cerebral microcirculation and reducing the supply of oxygen and nutrients ( Kotan et al, 2022 ; Wang et al, 2022 ). Ultimately, these changes in vascular function and abnormal vascular contractility can impact cerebral microcirculation and blood supply.…”

Section: Relationship Among Peripheral Inflammation Central Nervous S...mentioning

confidence: 99%

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Li,

Fang

et al. 2024

Front. Cell. Neurosci.

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General anesthesia, as a commonly used medical intervention, has been widely applied during surgical procedures to ensure rapid loss of consciousness and pain relief for patients. However, recent research suggests that general anesthesia may be associated with the occurrence of perioperative neurocognitive disorder (PND). PND is characterized by a decline in cognitive function after surgery, including impairments in attention, memory, learning, and executive functions. With the increasing trend of population aging, the burden of PND on patients and society’s health and economy is becoming more evident. Currently, the clinical consensus tends to believe that peripheral inflammation is involved in the pathogenesis of PND, providing strong support for further investigating the mechanisms and prevention of PND.

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Hemorheological and Microcirculatory Relations of Acute Pancreatitis

Cited by 2 publications

References 104 publications

Metabolites and lipoproteins may predict the severity of early Acute Pancreatitis in a South African cohort

Metabolites and lipoproteins may predict the severity of early Acute Pancreatitis in a South African cohort

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

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