Hemorheological alterations related to training and overtraining

Brun, Jean-Frédéric; Varlet‐Marie, Emmanuelle; Connes, Philippe; Aloulou, I.

doi:10.3233/bir-2010-0563

Cited by 64 publications

(34 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exercise training also induces adaptations of RBC aggregation [46] and RBC deformability [14]. Ernst et al [35] reported increased RBC deformability in athletes compared to sedentary subjects, a finding later confirmed by Smith et al [77].…”

Section: Healthy Populationmentioning

confidence: 89%

“…Indeed, significant correlations have been reported between resting blood fluidity and indices of physical fitness such as endurance time, physical work capacity at a heart rate of 170 bpm or maximal oxygen consumption (VO 2max ) [12]. Brun et al [14] proposed that decreased resting blood viscosity could improve O 2 delivery to muscle during exercise in trained individuals.…”

Section: Blood Viscosity Shear Rate and Nitric Oxidementioning

confidence: 99%

See 1 more Smart Citation

Exercise hemorheology: Classical data, recent findings and unresolved issues

Connes

Simmonds

Brun

et al. 2013

Clinical Hemorheology and Microcirculation

Self Cite

125

View full text Add to dashboard Cite

The present review focuses on the past and recent knowledge in the field of exercise hemorheology and presents some unresolved issues for opening discussion. Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having negative consequences for cardiovascular function and aerobic performance, recent findings suggest dynamic changes in blood viscosity might be useful for vascular function during exercise by increasing nitric oxide production. Other determinants of blood viscosity are altered by exercise (e.g., decreased red blood cell deformability, increased red blood cell aggregation and plasma viscosity) and may, independent of the associated effect on blood viscosity, directly modulate aerobic capacity. However, the data published on the effects of exercise on the hemorheology are not consistent, with some studies showing decreased, unchanged, or increased red blood cell deformability/aggregation when compared with rest. These discrepancies seem to be related to the exercise protocol investigated, the population tested or the methodogy utilized for hemorheological measurements. Finally, this review focuses on the effects of exercise training (i.e. chronic physical activity) on the hemorheological profile of healthy individuals and patients with cardiovascular and metabolic disorders. P. Connes et al. / Blood rheology and exerciseaddress classical findings in exercise hemorheology and will present new directions. In addition, some unresolved issues will be presented for opening discussion. Acute effects of exercise on hemorheology and relationships with performance2.1. Blood viscosity P. Connes et al. / Blood rheology and exercise 189 PRE 90 Blood viscosity (mPa/s) POST 90 POST 225 5 6 7 8 9

show abstract

Section: Healthy Populationmentioning

confidence: 89%

Section: Blood Viscosity Shear Rate and Nitric Oxidementioning

confidence: 99%

Exercise hemorheology: Classical data, recent findings and unresolved issues

Connes

Simmonds

Brun

et al. 2013

Clinical Hemorheology and Microcirculation

Self Cite

125

View full text Add to dashboard Cite

show abstract

“…Regular exercise (aerobic or resistance) usually reduces blood viscosity [53,54]. Exercise training also induces the rheological adaptation of RBCs [54,55]. One study on healthy volunteers who participated in regular exercise training over 12 weeks showed a decrease in blood viscosity and an increase in RBC deformability [56].…”

Section: Discussionmentioning

confidence: 99%

Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial

Kim

Jung

Park

et al. 2019

IJERPH

View full text Add to dashboard Cite

The present study examined the effect of a 12-week combined resistance and aerobic exercise training program on cardiometabolic biomarkers and red blood cell (RBC) hemorheological function in 20 obese older men (mean age: 68.8 ± 0.9 years). Subjects were randomly divided into two groups (exercise intervention [EXP; n = 10] and control [CON; n = 10]). The EXP subjects performed resistance and aerobic exercise training program three times per week for 12 weeks, and the CON subjects maintained their regular lifestyle during the intervention period. Body composition was estimated using bioelectrical impedance analysis equipment. Cardiometabolic biomarkers (glucose, insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), HOMA β-cell function, and leptin) and RBC hemorheological parameters (RBC deformability and aggregation) were analyzed. Percent body fat decreased significantly in the EXP group during the intervention period but increased significantly in the CON group. Insulin increased significantly in the CON group over the 12-week period and both insulin and HOMA-IR were significantly higher in the CON group than in the EXP group at post-test. RBC deformability (RBC EI_3Pa) and aggregation (RBC AI_3Pa) improved significantly only in the EXP group. The present study suggests that combined exercise training can be useful for improving cardiometabolic biomarkers and RBC hemorheological parameters in obese older men and may help prevent metabolic syndrome and cardiovascular diseases.

show abstract

“…The hemorheologic and hematological profile of athletes differs from the profile of non-athletes. Chronic and regular training results in a hemorhologic fitness, which is characterized by a lower Hct, a lower blood and plasma viscosity and a higher RBC deformability in athletes compared to non-athletes [7]. Besides, extensive training volumes have been associated to intravascular hemolysis of primarily old and rigid RBC in both, male and female athletes.…”

Section: Discussionmentioning

confidence: 99%

“…Hct was previously described to affect RBC deformability, since a low Hct goes along with a higher RBC deformability in athletes as part of the hemorheologic fitness [7]. It was observed that Hct negatively correlates with maximal aerobic capacity and was the best determinant of VO 2 max in athletes [13].…”

Section: Discussionmentioning

confidence: 99%