Hemopoietic Chimerism in Imported and Laboratory-Bred Marmosets

Gengozian, Nazareth; Js, Batson; Ct, Greene; Dg, Gosslee

doi:10.1097/00007890-196911000-00009

Cited by 45 publications

(42 citation statements)

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“…To date, we have found chimaerism in all heterosexual co-twin pairs, reflecting the consistent development of the vascular anastomoses (Gengozian, Batson, Greene & Gosslee, 1969;. Although single births occur, studies in our laboratory indicate that these animals may also be blood chimaeras Gengozian et al, 1969). This latter observation may be explained by the death and resorption of one twin foetus after contributing primordial cells to its co-twin; we have obtained evidence for the induction of chimaerism by this means (Gengozian, 1966).…”

supporting

confidence: 58%

“…Haemopoietic chimaerism, a consequence of the prenatal anastomoses, was subsequently found in imported adult marmosets by Bernirschke, Anderson & Brownhill (1962) and by Gengozian, Batson & Eide (1964). To date, we have found chimaerism in all heterosexual co-twin pairs, reflecting the consistent development of the vascular anastomoses (Gengozian, Batson, Greene & Gosslee, 1969;. Although single births occur, studies in our laboratory indicate that these animals may also be blood chimaeras Gengozian et al, 1969).…”

supporting

confidence: 57%

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Effect of Unilateral Ovariectomy on Twinning Frequency in the Marmoset

Gengozian¹,

Merritt²

1970

Reproduction

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supporting

confidence: 58%

supporting

confidence: 57%

Effect of Unilateral Ovariectomy on Twinning Frequency in the Marmoset

Gengozian¹,

Merritt²

1970

Reproduction

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“…Although considerable progress has been made in its management in captivity and there have been many reports of successful breeding from wild-caught individuals (Benirschke & Richart, 1963;Hampton, Hampton & Landwehr, 1966;Epple, 1970;Wolfe, Deinhardt, Ogden, Adams & Fisher, 1975;Cicmanec & Campbell, 1978;Gengozian, Batson & Smith, 1978;Brand, 1981;Tanioka & Izawa, 1981;French, 1983;Kilborn, Sehgal, Johnson, Beland & Bronson, 1983;Kirkwood, Epstein & Terlecki, 1983;Tardif, Richter & Carson, 1984), the successful rearing of babies by parents that have themselves been born in captivity (i.e. a second generation) has remained a serious hurdle as the paucity of records ' Epstein & Terlecki, 1983).…”

Section: Abstract: Breeding; Saguinusmentioning

confidence: 99%

Rearing a second generation of cotton-top tamarins (Saguinus oedipus oedipus) in captivity

et al. 1985

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SummaryThe average age al first parturition in captive-born female cotton-top lamarins was 31 months. Only 18% of full-term young born were successfully reared by primiparous females, but success increased with parity and 71% of babies born at 4th and 5th pregnancies were raised. 15% of litters were single births, 61% were twins and 24% were triplets. There was a seasonal distribution of births, with a clear peak in the spring months. The average interbirth interval was 294 days.

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“…Marmosets usually born twins or even triplets. Interestingly, the offspring are natural bone marrow chimeras because their blood system is connected due to placental vascular anastomoses (54,55). Yet, despite its importance in immunological research, only very few data on NK cell receptors are known for the common marmoset monkey (56), and for New World monkeys in general.…”

Section: Discussionmentioning

confidence: 99%

Genomics and Diversity of the Common Marmoset Monkey NK Complex

Averdam¹,

Kuhl

Sontag

et al. 2007

The Journal of Immunology

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The common marmoset monkey (Callithrix jacchus) is a New World primate that is increasingly used in biomedical research as a model organism. Due to the occurrence of natural bone marrow chimerism, it represents a particularly useful primate model in immunological research. In this study, we describe the genomic organization of the CD94, NKG2, and LY49L genes in the NK complex (NKC) of the common marmoset based on complete sequencing of a bacterial artificial chromosome clonal contig. This region of the marmoset NKC is 1.5 times smaller than its human counterpart, but the genes are colinear and orthologous. One exception is the activating NKG2CE gene, which is probably an ancestral form of the NKG2C-and NKG2E-activating receptor genes of humans and great apes. Almost all NK cell receptors are encoded in two gene clusters, the leukocyte receptor complex (LRC) 5 and the NK complex (NKC), which map to human chromosomes 19q13.4 (8) and 12p13 (9), respectively. LRC-encoded receptors contain Ig-like domains, whereas the NKC encodes C-type lectin-like receptors (10). Genes mapping to the NKC include CD94 and the families of Ly49 and NK group (NKG) 2 genes (4, 11). Whereas LY49 and NKG2D molecules form homodimers, CD94 and NKG2 molecules are expressed as heterodimers at the cell surface. The Ly49 gene family is expanded and diverse in rodents (12) and includes activating and inhibitory receptors that are characterized by presence of a positively charged residue in the transmembrane region and ITIM in the cytoplasmic region, respectively (13). The ITIM-containing inhibitory receptor NKG2A and the activating receptor NKG2C form heterodimers with the CD94 molecule, which exhibits neither an activating nor an inhibitory motif. The CD94/NKG2A and the CD94/NKG2C molecules interact with the nonclassical MHC class I ligand HLA-E (14). Recently, binding of CD94 and the activating receptor NKG2E has been demonstrated (15), while the function of NKG2F, which has a truncated extracellular lectin-like domain and binds intracellularly to DAP12, is still unknown (16). Although similarly named, the NKG2D molecule is only distantly related to the other members of the NKG2 family. NKG2D homodimers interact with stress-inducible MHC class I ligands MICA, MICB, ULBP1, ULBP2, ULBP3, and ULBP4 in humans (17-19) and RAET1A, RAET1B, RAET1G, RAET1E, H60, and MULT1 in mice (20,21). NKG2D signaling involves the ITAM-containing adaptor molecules DAP10 and DAP12. Notably, distinct splice products of NKG2D associate with DAP10 and DAP12 in mice (22, 23), but not in humans, where the NKG2D gene is not differentially spliced and its product associates with DAP10 only (24).The CD94 gene is monomorphic and the NKG2 genes are moderately polymorphic in humans and common chimpanzees, and all genes are subject to alternative splicing (25,26). In this study, we show the complete sequence and organization of the CD94-LY49L genomic interval in a New World monkey species, the common marmoset (Callithrix jacchus). The NKC of the common marmoset monkey encodes o...

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Hemopoietic Chimerism in Imported and Laboratory-Bred Marmosets

Cited by 45 publications

References 0 publications

Effect of Unilateral Ovariectomy on Twinning Frequency in the Marmoset

Effect of Unilateral Ovariectomy on Twinning Frequency in the Marmoset

Rearing a second generation of cotton-top tamarins (Saguinus oedipus oedipus) in captivity

Genomics and Diversity of the Common Marmoset Monkey NK Complex

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