Hemophilus influenzae Type b Disease

Redmond, Stephen R.

doi:10.1001/jama.1984.03350180035026

Cited by 78 publications

(3 citation statements)

References 20 publications

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“…Day care attendance has been found to increase the risk of invasive H.influenzae disease. 13 " 17 However, in our study control children attended day care more often than cases. In Switzerland, vaccination is not required for day care or school attendance.…”

Section: Discussioncontrasting

confidence: 54%

“…Three previous investigations had shown that the risk associated with day care was highest under the age of 2 years and waned thereafter. 131516 Redmond and Picchichero 13 hypothesized that longer duration of day care may lead to greater isoimmunization (i.e. exposure to cross reactive antigens carried by other bacteria) and protection from disease.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors for Invasive Haemophilus influenzae Disease among Children 2-16 Years of Age in the Vaccine Era, Switzerland 1991-1993

Mühlemann

Alexander

Weiss

et al. 1996

International Journal of Epidemiology

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Risk Factors for Invasive Haemophilus influenzae Disease among Children 2-16 Years of Age in the Vaccine Era, Switzerland 1991-1993

Mühlemann

Alexander

Weiss

et al. 1996

International Journal of Epidemiology

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“…These family members may well act as possible spreaders of Hib organisms in the community. It is well known that household contacts of colonized day-care children are a reservoir of Hib (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Genetic and Phenotypic Characterization of <i>Haemophilus influenzae</i> Type b Isolated from Children with Meningitis and Their Family Members in Vietnam

Huong,

Thi,

Anh

et al. 2006

Jpn J Infect Dis

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To investigate Haemophilus influenzae type b (Hib) infection in Vietnamese children under the age of 5 years, cerebrospinal fluid (CSF) samples from patients with meningitis were screened for Hib, and isolates were subjected to evaluation of susceptibility to 12 antibiotics, biotyping, and genotyping with pulsed-field gel electrophoresis (PFGE). The major biotype was type II (68.3%), followed by type I (22.8%). Among 79 Hib isolates, 45 (57%) were β-lactamase-producing and ampicillin-resistant (44 and 1 isolates produced TEM-1and ROB-1-type β-lactamases, respectively), and 34 isolates (43%) were β-lactamase-nonproducing and ampicillin-sensitive. No β-lactamase-nonproducing and ampicillin-resistant isolates were found. The PFGE patterns of Hib isolates were highly divergent, but most could be classified into three clusters. We also investigated Hib colonization in household contacts of patients, and found that Hib isolates from the CSF of patients and from nasopharyngeal cavities of household contacts showed the same PFGE patterns. This observation suggested that household contacts of patients are a possible reservoir of Hib.

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Clinical and Economic Impact of a Combination Haemophilus influenzae and Hepatitis B Vaccine

Fendrick¹,

Lee²,

LaBarge³

et al. 1999

Arch Pediatr Adolesc Med

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Background: Compliance with hepatitis B virus (HBV) vaccine remains suboptimal, despite a recommendation by the Advisory Committee on Immunization Practices of the US Public Health Service that all newborns be vaccinated. Although a combined HBV-Haemophilus influenzae type b (Hib) vaccine may improve acceptance of the HBV vaccine, the clinical and economic consequences of this intervention are uncertain. Objectives: To compare the health impact and costeffectiveness of the following 2 immunization strategies: current practice of administering HBV vaccine separately (75% compliance) and Hib vaccine alone or as part of a multivalent vaccine (95% compliance); and strategy of delivering a combined HBV-Hib vaccine (95% compliance). Design: A Markov model simulated the natural history of acute and chronic HBV and Hib disease in a cohort of US newborns. Clinical and economic variables were obtained from published reports. Results: The Hib-related outcomes were the same in both strategies, because the efficacy and compliance with Hib vaccine were assumed to be equivalent in both. A 53% reduction in the number of cases of HBV infection with the combination strategy (n = 8541) was estimated when compared with current practice (n = 18 044), along with 205 fewer HBV-related deaths per 1 million infants.

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Hemophilus influenzae Type b Disease

Cited by 78 publications

References 20 publications

Risk Factors for Invasive Haemophilus influenzae Disease among Children 2-16 Years of Age in the Vaccine Era, Switzerland 1991-1993

Risk Factors for Invasive Haemophilus influenzae Disease among Children 2-16 Years of Age in the Vaccine Era, Switzerland 1991-1993

Genetic and Phenotypic Characterization of <i>Haemophilus influenzae</i> Type b Isolated from Children with Meningitis and Their Family Members in Vietnam

Clinical and Economic Impact of a Combination Haemophilus influenzae and Hepatitis B Vaccine

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