Hemophagocytic syndrome associated with visceral leishmaniasis

Kilani, B.; Ammari, L.; Kanoun, F.; Chaabane, T. Ben; Abdellatif, Sami; Chaker, E.

doi:10.1016/j.ijid.2005.03.003

Cited by 19 publications

(11 citation statements)

References 5 publications

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“…11 Liver biopsy 26 and blood cultures, 11 where feasible, may also reveal the presence of hemophagocytosis and leishmaniasis, in the presence of a negative marrow. 14,17,28 The yield of liver biopsy is variable and it may show a non-specific hepatitis-like lymphocytic infiltration only. 36 Though splenic aspiration is the gold standard in VL 37 and may demonstrate HLH, few patients of VL associated HLH have undergone the same.…”

Section: Resultsmentioning

confidence: 99%

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Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis – Case report and systematic review

Srinivas

Dutta

Chandra

et al. 2008

Journal of Infection

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Section: Resultsmentioning

confidence: 99%

“…10,11,13e17 All patients responded to specific therapy and untreated disease was invariably fatal. 22,28 One third of the patients required adjunctive therapy (32.3%), especially with delayed diagnosis. The mean delay in diagnosis of the reported cases was 9 weeks (range 1 weeke8.5 months).…”

Section: Resultsmentioning

confidence: 99%

Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis – Case report and systematic review

Srinivas

Dutta

Chandra

et al. 2008

Journal of Infection

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“…Among infection associated HLH, Epstein Barr Virus is certainly the most common trigger [2]. Additional typical triggers include other Herpes viruses, Leishmania and H1N1 influenz [3–5]. There are a number of cases associated with lymphoma and leukaemia, most frequently T cell receptor gamma-delta bearing T cell lymphomas.…”

Section: Introductionmentioning

confidence: 99%

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome

2017

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BackgroundMacrophage activation syndrome (MAS) is a severe complication of rheumatic disease in childhood, particularly in systemic Juvenile Idiopathic Arthritis (sJIA). It is characterize by an uncontrolled activation and proliferation of T lymphocytes and macrophages.Main contentMAS is currently classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH). The reason is that MAS shares clinical and laboratory features with primary genetic HLH (pHLH). In this context is conceivable that some of the pathogenic mechanisms of pHLH may be involved in other forms of HLH. Heterozygosity for mutations of genes involved in pHLH may lead to a cytotoxic defect and to a development of clinical overt disease. But other different contributors might be involved to the development of MAS such as infections or underlying inflammation. In MAS, the inflammatory status of the patient is a major contributor of the disease. Indeed, the majority of the MAS episodes occurs during active disease phases or at disease onset. In addition, recent evidence in animals and humans suggest that genetics may also play a major role in contributing to hyperinflammation and particularly to macrophages hyper-responses.ConclusionsWe hypothesize that HLH may be one unique clinical syndrome, to whose generation different mechanisms may contribute, and maintained by one final effector mechanism.

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“…Nevertheless, some reports have described the association with human immunodeficiency virus (HIV), adenovirus, coxsackie virus, measles, dengue, rubella, parvovirus B19, herpes simplex virus and varicella zoster virus 39 . Moreover, some cases of hemophagocytic syndrome have been reported in bacterial and protozoan infections 16,21 .…”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

Tuon

Gomes

Amato

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVirus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.

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Hemophagocytic syndrome associated with visceral leishmaniasis

Cited by 19 publications

References 5 publications

Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis – Case report and systematic review

Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis – Case report and systematic review

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

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