Hemophagocytic Lymphohistiocytosis in B-Cell Lymphoproliferative Disorder: Report of a Rare Association

Hemophagocytic L Ymphohistiocytosis

“…Most centres treats HLH according to HLH-1994 protocol in which cyclosporine is not a part of induction, we have chosen to start cyclosporine from the beginning of therapy in this case, in view of prolonged illness of patient without treatment, but he was unable to tolerate the drug and it was discontinued. Literature on HLH in India it is mostly confined to children [6][7][8][9][10] and there are only few adult HLH reports [11,12]. In the present case complete work up was done including molecular analysis with successful outcome following therapy.…”

Primary lymphoma of the brain in a young man whose brother died of hemophagocytic lymphohistiocytosis: Case report

“…The most important of our findings is unique occurrence of PCNSL in the family with genetically confirmed HLH. Recently, some associations of HLH with B-cell lymphoproliferative disorder has been reported [7][8][9][10][11], but only this case report describes primary brain lymphoma in a young man whose brother died of HLH.…”

Primary Lymphoma of the Brain in a Young Man Whose Brother Died of Hemophagocytic Lymphohistiocytosis: Case Report

“…Recently, some associations of HLH with B-cell lymphoproliferative disorder has been reported [7][8][9][10][11], but only this case report describes primary brain lymphoma in a young man whose brother died of HLH. Outcome of patients with relapse of PCNSL is generally poor, with the median survival time of 2-5 months [12].…”