Hemophagocytic Lymphohistiocytosis Associated With Visceral Leishmaniasis

Özdemir, Nihal; Koç, Başak; Arslantaş, Esra; Al, Işık Odaman; Kelleci, Çiğdem; Uysalol, Ezgi; Bayram, Cengiz; Ayçiçek, Ali

doi:10.1097/mph.0000000000001178

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinicians should distinguish between primary and secondary HPS, and make a clear etiological diagnosis of secondary HPS. The possibility of VL should be considered when diagnosing HPS[ 8 , 9 ]. Treatment measures for secondary HPS should be established according to the primary disease; following treatment appropriate for primary HPS may lead to adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Next-generation sequencing technology for diagnosis and efficacy evaluation of a patient with visceral leishmaniasis: A case report

Lin¹,

Sun²,

Wang³

et al. 2021

WJCC

View full text Add to dashboard Cite

BACKGROUND Visceral leishmaniasis (VL) is a parasitic disease caused by Leishmania and transmitted by infected sand flies. VL has a low incidence in China, and its clinical presentation is complex and atypical. This disease is easily misdiagnosed and can become life-threatening within a short period of time. Therefore, early, rapid and accurate diagnosis and treatment of the disease are essential. CASE SUMMARY A 25-year-old male patient presented with the clinical manifestations of irregular fever, hepatosplenomegaly, increased polyclonal globulin, and pancytopenia. The first bone marrow puncture biopsy did not provide a clear diagnosis. In order to relieve the pressure and discomfort of the organs caused by the enlarged spleen and to confirm the diagnosis, splenectomy was performed, and hemophagocytic syndrome was diagnosed by pathological examination of the spleen biopsy. Following bone marrow and spleen pathological re-diagnosis and metagenomic next-generation sequencing (mNGS) technology detection, the patient was finally diagnosed with VL. After treatment with liposomal amphotericin B, the body temperature quickly returned to normal and the hemocytes recovered gradually. Post-treatment re-examination of the bone marrow puncture and mNGS data showed that Leishmania was not detected. CONCLUSION As a fast and accurate detection method, mNGS can diagnose and evaluate the efficacy of treatment in suspicious cases of leishmaniasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Next-generation sequencing technology for diagnosis and efficacy evaluation of a patient with visceral leishmaniasis: A case report

Lin¹,

Sun²,

Wang³

et al. 2021

WJCC

View full text Add to dashboard Cite

show abstract

Quando non trascurare la splenomegalia nel lattante

et al. 2021

View full text Add to dashboard Cite

Splenomegaly in children is really common and its main cause is infectious disease. The aetiology in newborns and older children is well established, while it is less defined in suckling infants. The paper describes three cases of splenomegaly in infants hospitalized in Oncohaematology Department of Sant’Orsola Malpighi Hospital. These infants presented with splenomegaly associated with other signs and symptoms that should prompt further investigations to exclude severe diseases. The aim of this paper is to offer paediatricians some indications for the diagnostic approach in infants with enlarged spleen. In particular, it reports the first level exams, the differential diagnosis and the red flags, the signs and symptoms that require special attention in infants with splenomegaly.

show abstract

Hemophagocytic Lymphohistiocytosis Associated With Visceral Leishmaniasis

Cited by 2 publications

References 2 publications

Next-generation sequencing technology for diagnosis and efficacy evaluation of a patient with visceral leishmaniasis: A case report

Next-generation sequencing technology for diagnosis and efficacy evaluation of a patient with visceral leishmaniasis: A case report

Quando non trascurare la splenomegalia nel lattante

Contact Info

Product

Resources

About