Hemophagocytic lymphohistiocytosis and acute Chagas disease, Colombia

Gómez, Carlos; Vargas-Hernández, Diego A.; Largo, Jorge; Hernández, Sebastián; Faccini-Martínez, Álvaro A.

doi:10.1016/j.tmaid.2021.102213

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…The results of an NK cell activity test were also abnormal (Figure 1D ). Thus, HLH after ASCT was diagnosed and VP16 with GCs administered[ 6 ].…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Zhang¹,

Dou²,

Yan³

et al. 2023

World J Clin Cases

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BACKGROUND Angioimmunoblastic T-cell lymphoma (AITL), a unique subtype of peripheral T-cell lymphoma, has relatively poor outcomes. High-dose chemotherapy with autologous stem cell transplantation (ASCT) can achieve complete remission and improve outcomes. Unfortunately, subsequent T-cell lymphoma-triggered hemophagocytic lymphohistiocytosis (HLH) has a worse prognosis than B-cell lymphoma-triggered HLH. CASE SUMMARY We here report a 50-year-old woman with AITL who achieved a favorable outcome after developing HLH 2 mo after receiving high-dose chemotherapy/ ASCT. The patient was initially admitted to our hospital because of multiple enlarged lymph nodes. The final pathologic diagnosis, made on biopsy of a left axillary lymph node was AITL (Stage IV, Group A). Four cycles of the following chemotherapy regimen were administered: Cyclophosphamide 1.3 g, doxorubicin 86 mg, and vincristine 2 mg on day 1; prednisone 100 mg on days 1-5; and lenalidomide 25 mg on days 1-14. The interval between each cycle was 21 d. The patient received a conditioning regimen (busulfan, cyclophosphamide, and etoposide) followed by peripheral blood stem cell infusion. Unfortunately, she developed sustained fever and a low platelet count 17 d after ACST, leading to a diagnosis of HLH after ASCT. During treatment, she experienced thrombocytopenia and Pneumocystis carinii pneumonia. The patient was successfully treated with etoposide and glucocorticoids. CONCLUSION It is possible that development of HLH is related to immune reconstitution after ASCT.

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“…The results of an NK cell activity test were also abnormal (Figure 1D ). Thus, HLH after ASCT was diagnosed and VP16 with GCs administered[ 6 ].…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Zhang¹,

Dou²,

Yan³

et al. 2023

World J Clin Cases

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show abstract

“…Up to 35% of acute Chagas disease cases have complications, the most frequent of which are pericardial effusion, myocarditis, and heart failure (1,5). In rare cases, hemophagocytic lymphohistiocytosis can develop, as reported in the case of a soldier from Colombia (6).…”

mentioning

confidence: 99%

Acute Chagas Disease Outbreak among Military Personnel, Colombia, 2021

Vergara,

Gómez,

Faccini-Martínez

et al. 2023

Emerg. Infect. Dis.

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We report an acute Chagas disease outbreak among soldiers in Colombia. Trypanosoma cruzi infection was confirmed through parasitology, serology, and molecular methods. Among 9 affected soldiers, 2 died; 7 were hospitalized and received benznidazole treatment, which produced favorable outcomes. Personnel patrolling rural areas in Colombia could be at increased risk for Chagas disease.

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Hemophagocytic lymphohistiocytosis and acute Chagas disease, Colombia

Cited by 2 publications

References 9 publications

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Acute Chagas Disease Outbreak among Military Personnel, Colombia, 2021

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