Hemolytic uremic syndrome with central nervous system manifestations, a case report and literature review

Mansour, Moustafa; Khalil, Dyana F.; Hasham, Mohab A.; Youssef, Ahmed M.; Rashad, M.M.; Awadallah, Muhammad; Argani, Hassan

doi:10.1016/j.radcr.2023.02.035

Cited by 4 publications

(2 citation statements)

References 16 publications

(37 reference statements)

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“…Along with close follow-up, 24-h Holter ECG and antiarrhythmic drugs should be considered in patients with increased cardiovascular risk. At the same time, these patients may be predisposed in terms of neurological symptoms and central nervous system involvement [ 17 , 18 ]. Especially considering that peripheral and autonomic nervous system involvement may be subclinical, the HRV seems very useful as a non-invasive parameter that can be used to evaluate patients in this respect.…”

Section: Discussionmentioning

confidence: 99%

Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome

Duman,

Sürmeli Döven,

Karpuz

et al. 2024

Eur J Pediatr

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In pediatric patients with hemolytic uremic syndrome (HUS), cardiac involvement and autonomic nervous system function can be evaluated by a non-invasive method called heart rate variability (HRV). This study aims to evaluate heart rate variability and electrocardiography findings in patients with HUS by comparing a healthy group. Patients who are diagnosed with HUS at a university hospital from December 2020 to June 2022 are screened by electrocardiography (ECG), echocardiography, and 24-h Holter ECG. A healthy control group, compatible in age and gender with the patient group, was selected from healthy subjects. HRV parameters, laboratory values, and ECG findings were analyzed and compared with the healthy group and each other. There were 25 patients with HUS and 51 participants in the healthy control group. Statistically significant differences were found in some HRV parameters: standard deviation of normal to normal intervals, the mean of the 5-min RR interval standard deviations, the standard deviation of 5-min RR interval means, the triangular interpolation of normal to normal interval, and very-low-frequency power. HUS patients had impaired and declined HRV values compared to the healthy group. There was a significant decrease in the PR distance, while a significant increase in the corrected QT and QT dispersion values was detected in the electrocardiographic findings of the patient group. HRV values impaired as renal failure parameters increased. Conclusion: Patients with HUS may have autonomic nervous system dysfunction. HRV measurement is a non-invasive method that can evaluate this. It can be thought that there may be an increased risk of cardiovascular events and arrhythmias in some patients with HUS. ECG should be also considered to detect arrhythmia. What is Known:• Hemolytic uremic syndrome (HUS) primarily effects the hematologic parameters and kidney.• Secondary cardiomyopathy with hypertension and renal failure could be observed in these patients.• Rhythm problems are not expected primarily in these patients.• There is very limited data in evaluating autonomic function and arrhythmia risk for these patients. What is New:• Patients with HUS may have autonomic nervous system dysfunction.• HRV measurement is a non-invasive method that can evaluate this.• Cardiovascular events and arrhythmias due to the deterioration of the balance between the sympathetic and parasympathetic systems could manifest in patients with HUS.• An ECG and screening patients for cardiac events, and monitoring them closely should be considered.

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Section: Discussionmentioning

confidence: 99%

Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome

Duman,

Sürmeli Döven,

Karpuz

et al. 2024

Eur J Pediatr

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“…E. coli strains cause lysis of red blood cells. Toxins from these bacteria are absorbed in endothelial cells where there are many toxin receptors (Feuerstein et al 2022;Pokharel et al 2023), thus can lead to hemolytic uremic syndrome or may leads to neurological symptoms (Nasir et al 2019;Mansour et al 2023). For this reason, it is generally recommended to cook meat at temperature ranging from 63 to 74˚C depending on the type of meat (US Departement of Health and Human Services 2022).…”

Section: Discussionmentioning

confidence: 99%

Microbial Investigation of Animal Product Hygiene in Bali and Nusa Tenggara of Indonesia

2023

Int J Vet Sci

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Products of animal origin, namely meat, eggs, and milk, must have good value and quality for human benefit and must be monitored regularly. The present study aimed to review the epidemiological mapping of the level of microbial contamination based on surveillance data in the Provinces of Bali and Nusa Tenggara. During 2017, a total of 1875 samples were collected from targeted places that did not have a veterinary control number (VCN) such as slaughterhouses, traditional markets, retail shops and meat supply companies (importers), then brought to the Disease Investigation Center (DIC) Denpasar for analysis. Microbial contamination was tested using the total plate count (TPC) method, according to laboratory procedures for DIC Denpasar. The test results showed that 56.9% of the samples contained germs that exceeded the maximum microbial contamination limit (MMCL) stipulated in SNI 7388: 2009, namely 1x10 6 colonies/g. The contaminant germs were dominated by E. coli (73.8%). There was a highly significant (P<0.001) difference in the number of E. coli that exceeded the maximum limit microbial contamination (MLMC) values detected between the three provinces, the four types of samples tested, and the type of slaughterhouses/markets. However, all samples tested did not contain pathogenic bacteria such as Staphylococcus aureus, Salmonella spp., and Campylobacter spp. This data suggested that the hygiene level of animal products in the region was low which can threaten the health of consumers.

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Preclinical diagnostics hemolytic-uremic syndrome in a child. Clinical observation

Olkhova,

Soboleva,

Fedoseeva

2024

jour

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Hemolytic — uremic syndrome (HUS) is one of the most severe conditions in pediatric practice. Acute kidney failure (AKF), which is a component of HUS, requires the earliest diagnosis and emergency medical care. Most of the young patients suffer from diarrhea-associated (D+) HUS, so ultrasound marks of kidney injury very important for young patients with severe hemocolitis. In this article we present the observation of preclinical diagnostics AKF the child 2 years and 11 month old with hemocolitis, when HUS’s marks (such as structure’s changes of the renal parenchyma and critical changes of renal hemodynamics) were detected before clinical manifestation AKF. This observation is illustrated with echograms and accompanied by a brief review of the literature.

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Hemolytic uremic syndrome with central nervous system manifestations, a case report and literature review

Cited by 4 publications

References 16 publications

Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome

Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome

Microbial Investigation of Animal Product Hygiene in Bali and Nusa Tenggara of Indonesia

Preclinical diagnostics hemolytic-uremic syndrome in a child. Clinical observation

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