Hemolytic Uremic Syndrome Risk and<i>Escherichia coli</i>O157:H7

“…Although infection by this organism typically causes symptoms such as watery or bloody diarrhea, it may also lead to the development of hemolytic-uremic syndrome (HUS), an infection sequela characterized by hemolysis and renal failure that can result in long-lasting kidney damage. Variables that contribute to the development of HUS include host factors, such as age (51), and the genetic background of the enterohemorrhagic E. coli (EHEC) isolate. Currently, no effective prophylaxis exists for HUS (45).…”

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confidence: 99%

Analysis of the Genome of theEscherichia coliO157:H7 2006 Spinach-Associated Outbreak Isolate Indicates Candidate Genes That May Enhance Virulence

et al. 2009

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In addition to causing diarrhea, Escherichia coli O157:H7 infection can lead to hemolytic-uremic syndrome (HUS), a severe disease characterized by hemolysis and renal failure. Differences in HUS frequency among E. coli O157:H7 outbreaks have been noted, but our understanding of bacterial factors that promote HUS is incomplete. In 2006, in an outbreak of E. coli O157:H7 caused by consumption of contaminated spinach, there was a notably high frequency of HUS. We sequenced the genome of the strain responsible (TW14359) with the goal of identifying candidate genetic factors that contribute to an enhanced ability to cause HUS. The TW14359 genome contains 70 kb of DNA segments not present in either of the two reference O157:H7 genomes. We identified seven putative virulence determinants, including two putative type III secretion system effector proteins, candidate genes that could result in increased pathogenicity or, alternatively, adaptation to plants, and an intact anaerobic nitric oxide reductase gene, norV. We surveyed 100 O157:H7 isolates for the presence of these putative virulence determinants. A norV deletion was found in over one-half of the strains surveyed and correlated strikingly with the absence of stx 1 . The other putative virulence factors were found in 8 to 35% of the O157:H7 isolates surveyed, and their presence also correlated with the presence of norV and the absence of stx 1 , indicating that the presence of norV may serve as a marker of a greater propensity for HUS, similar to the correlation between the absence of stx 1 and a propensity for HUS.

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“…The case of fatal gastrointestinal infection with E. Enterohaemorrhagica coli O157: H7, is an illustrative example of how the health service is sometime unable to fight with the micro -world [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Lesions in the course of HUS as result of action of toxins (Stx), produced by E. coli O157: H7. [6].…”

Section: Discussionmentioning

confidence: 99%

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Fatal Outcome of Alimentar Escherichia Coli O157: H7 Toxiinfection

Andric

Mijović

Soc

2016

JHVRV

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Medical records showed that in two young tourists, different gender from Macedonia developed at the same time symptoms of acute alimentary toxiinfection. In male person, there was regression of symptoms after completion of home treatment (oral rehydratation and diet).In the female case (18 years) home treatment conducted under the same conditions, did not yield satisfactory results. Disease progression was monitored clinically from the appearance of sub febrile temperature, with vomiting, watery diarrhea and abdominal pain to development of hemorrhagic colitis (spasmodic pain in the lower abdomen, then bloody diarrhea), which forced her to search medical help. The dramatic course of the development of clinical disease, occur 7-8 days after onset. Coincides with the early development of hemolytic uremic syndrome (HUS), and later development of acute renal failure. Those 18-th days from the onset of the disease ended in death. In the last stage of hospital treatment and analyzing, at the Nephrology Clinic in Skopje, swab of the mucous membrane proved verotoxin of E. coli O157. Fatal Outcome of Alimentar Escherichia Coli O157: H7 Toxiinfection 2/4

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Hemolytic Uremic Syndrome Risk andEscherichia coliO157:H7

Cited by 45 publications

References 14 publications

Shiga Toxin Associated Hemolytic Uremic Syndrome

Shiga Toxin Associated Hemolytic Uremic Syndrome

Analysis of the Genome of theEscherichia coliO157:H7 2006 Spinach-Associated Outbreak Isolate Indicates Candidate Genes That May Enhance Virulence

Fatal Outcome of Alimentar Escherichia Coli O157: H7 Toxiinfection

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