Hemolytic Transfusion Reaction Probably Caused by Anti‐Le<sup>a</sup>

Brendemoen, O. J.; K, Aas

doi:10.1111/j.0954-6820.1952.tb14236.x

Cited by 22 publications

(2 citation statements)

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“…Agglutination of red cells in presence of anti-Lewis antibodies exhibited a characteristic stringy appearance resembling chains of cells when observed microscopically (Figure 1), while incompatible cross match showed an area of irregular agglutination or rouleaux of red cells (Figure 2). [7][8][9] . It is shown that the presence of Le antibodies may cause some difficulties in cross-match techniques in blood transfusion 6,10 .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Lewis Blood Group among Bangladeshi Population

Dipta

Rahman

Khatun

et al. 2017

Anwer Khan Mod Med Coll J

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Background: The Lewis system differs from all other blood group systems. It is primarily a system of soluble antigens originate in the tissue of body secretions, such as saliva (glycoprotein) and in plasma (glycolipid) respectively.The ABH secretor status influences red cells of Lewis phenotype and this phenotype may be modified by the ABO phenotype.Methodology: A cross sectional study was done to determine the presence of Lewis antigens in patients and voluntary donor's blood and observe the agglutination pattern during blood cross matching. In this study 350 blood samples were tested by hemagglutination -monoclonal antibodies.Result: Our study showed, Lewis antibody was detected in 50.8 % cases. The presence of anti-Leb was more frequent (69.7%) than anti-Lea in association with ABO blood group. Lewis anti-Leb was most common in O group (75.0%) followed by group-A (69.0%) where as anti-Lea was predominant in B (37.7%) followed by AB (33.3%).Moreover among Lewis phenotypes, Le (a-b+) was present in 35.4% cases, Le (a+ b-) in 15.1% and Le (a+ b+) was rare (0.3%). Phenotype Le (a-b-) represents all negative cases 172 in number (49.2%).Conclusion: Presence of Lewis antibody cause irregular agglutination interfering with interpretation of compatibility testing. So the patients with multiple transfusions or having atypical or irregular antibodies should routinely test for Lewis blood group antibodies to avoid untoward reactions.Anwer Khan Modern Medical College Journal Vol. 7, No. 2: Jul 2016, P 12-15

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Section: Resultsmentioning

confidence: 99%

Prevalence of Lewis Blood Group among Bangladeshi Population

Dipta

Rahman

Khatun

et al. 2017

Anwer Khan Mod Med Coll J

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“…[3] Amongst the Lewis antibodies, anti-Le a is more frequently associated with acute HTRs[29303132] than is anti-Le b . [3334] Cases of delayed HTRs have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of antibody specificities to M, N and Lewis blood group system

Makroo

Arora

Bhatia

et al. 2014

Asian J Transfus Sci

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Context:The clinically significant antibodies are those active at 37°C and/or by the indirect antiglobulin test. Most of the published literature refers to antibodies of Lewis blood group system to be insignificant, whereas antibodies to M and N blood groups are associated with variable clinical significance.Aims:The aim of this study is to find the frequency and clinical significance of antibodies to M, N and Lewis blood group systems.Settings and Design:The study was carried out retrospectively from January 2009 to December 2012.Materials and Methods:Antibody screening was performed by solid phase red cell adherence (SPRCA) technique using four cell screening panel on a fully automated platform GALILEO (Immucor Inc. USA). In case of a positive antibody screen, antibody identification was performed using SPRCA (GALILEO, Immucor Inc. USA).Results:A total of 49,077 red cell antibody screens were performed and a total of 427 identifications of red cell antibodies were carried out. A total of 304 specific antibodies were detected: 8.22% of antibodies were of anti-M specificity and 2.96% were of anti-N specificity. Majority (84%) of anti-M and 77.78% of anti-N were of Immunoglobulin G (IgG) class reacting at 37°C. 1.31% of the antibodies were directed against Lewis system antigens of which 0.65% were anti-Lea and 0.65% were anti-Leb. Half of the Lewis system antibodies, i.e., 1 each of anti-Lea and anti-Leb were of IgG class.Conclusion:Our study highlights the importance of detecting the thermal amplitude of antibodies with variable clinical significance especially if both IgG and IgM types of antibodies are associated with it so as to establish their clinical significance.

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