Hemolytic characteristics of three commercially available centrifugal blood pumps

Lawson, D. Scott; Ing, Richard J.; Cheifetz, Ira M.; Walczak, Rich; Craig, Damian M.; Schulman, Scott R.; Kern, Frank H.; Shearer, Ian R.; Lodge, Andrew J.; Jaggers, James

doi:10.1097/01.pcc.0000163282.63992.13

Cited by 93 publications

(50 citation statements)

References 22 publications

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“…In comparison with traditional roller pumps, the centrifugal pump has virtually no risk of tubing rupture or spallation; it has a smaller priming volume, it does not require the use of a reservoir, and the new generation of centrifugal pumps have an equivalent incidence of hemolysis. 17 Several large series now report survival of Ͼ50% for VV ECMO in acute, severe respiratory failure. 18,19 Currently, there are no randomized, controlled trials to support the use of the new ECMO circuits in the management of severe, acute respiratory failure, but such a trial (the CESAR trial) is nearing completion in the UK.…”

Section: Discussionmentioning

confidence: 98%

Use of Extracorporeal Membrane Oxygenation as a Bridge to Primary Lung Transplant: 3 Consecutive, Successful Cases and a Review of the Literature

Jackson

Cropper

Pye

et al. 2008

The Journal of Heart and Lung Transplantation

101

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Section: Discussionmentioning

confidence: 98%

Use of Extracorporeal Membrane Oxygenation as a Bridge to Primary Lung Transplant: 3 Consecutive, Successful Cases and a Review of the Literature

Jackson

Cropper

Pye

et al. 2008

The Journal of Heart and Lung Transplantation

101

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“…19,20 However, prudence dictates that in view of the much higher incidence of dangerous hemolysis using the centrifugal pump (59 versus 11%), attempts be made to design a pump to use less volume, to be less occlusive and to be more compact. Our in vitro testing model might be useful in comparing new pump designs especially if the difference in hemolysis caused by centrifugal versus roller pumps could be established in vitro as standards of comparison.…”

Section: Discussionmentioning

confidence: 99%

Increased hemolysis from saline pre-washing RBCs or centrifugal pumps in neonatal ECMO

et al. 2007

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Objectives: Hemolysis is a significant complication of extracorporeal membrane oxygenation (ECMO), with a reported incidence of 12.2%. The aims of this study were (1) to investigate hemolysis caused by saline-washed versus unwashed RBCs, (2) to determine in vitro the effects of saline washing on erythrocyte hemolytic markers and (3) to investigate hemolysis by centrifugal versus roller pumps.Study design: (1) To evaluate the effect of pre-transfusion saline-washing versus non-washing, the peak plasma-free hemoglobin (FHb) and total bilirubin in the first 3 days versus the next 4 days of ECMO were compared (2) Pre-and postsaline-washed RBCs were analyzed for K þ , hemoglobin, mean corpuscular volume, FHb and hemolysis at baseline and after 4 h of storage at 41C. (3) Over 10 000 neonatal ECMO cases were retrospectively reviewed to study the effect of pump type on hemolysis.Results: (1) The washed blood group had significantly more hemolysis within the first 3 days of ECMO. (2) Immediately after saline washing, the K þ and Hb concentrations were significantly decreased compared with unwashed blood, and these differences were maintained after 4 h. The osmotic fragility of washed RBCs after 4 h of storage at 41C was significantly higher than at baseline. (3) Hemolysis was reported more often in the centrifugal than in the roller pump group.Conclusions: (1) Using unwashed RBCs decreased hemolysis within the first 3 days of ECMO. (2) Saline washing, while decreasing the concentration of K þ in the plasma, significantly increases RBC membrane osmotic fragility. (3) Hemolysis is linked to the use of centrifugal pumps.

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“…However, there have been significant advances in perfusion technology since then; polymethylpentene oxygenators [13,14] and centrifugal pumps [15,16] are capable of several weeks of continuous operation with a low incidence of haemolysis, while heparin-coated circuit components cause less systemic inflammation [17,18] and require lower levels of systemic anticoagulation than non-coated circuits.…”

Section: Ecmo and Ardsmentioning

confidence: 99%

Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience

Forrest

Ratchford

Burns³

et al. 2011

Intensive Care Med

119

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Patients with very severe respiratory failure, which was considered to preclude conventional ventilation for safe transfer to tertiary centres, were managed by an ECMO referral and retrieval program in NSW and had a high rate of survival. This program also enhanced the capacity of the state to respond to a surge in demand for ECMO support due to the H1N1 epidemic, although the role of ECMO in respiratory failure is not yet well defined.

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Hemolytic characteristics of three commercially available centrifugal blood pumps

Abstract: These data are encouraging for the development of a low-prime, mobile neonatal extracorporeal membrane oxygenation circuit using centrifugal pump technology.

Cited by 93 publications

References 22 publications

Use of Extracorporeal Membrane Oxygenation as a Bridge to Primary Lung Transplant: 3 Consecutive, Successful Cases and a Review of the Literature

Use of Extracorporeal Membrane Oxygenation as a Bridge to Primary Lung Transplant: 3 Consecutive, Successful Cases and a Review of the Literature

Increased hemolysis from saline pre-washing RBCs or centrifugal pumps in neonatal ECMO

Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience

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