Hemolytic Anemia Secondary to Sali cylazosulfapyri dine Therapy

Gardner, Morris D.; Bargen, J. Arnold

doi:10.1001/jama.1964.03070140077021

Cited by 13 publications

(2 citation statements)

References 6 publications

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“…The most frequent haematological complication of sulphasalazine therapy is Heinz body formation, which occurs in 8%y of the patients treated with the drug (Bottinger et al, 1963), but Heinz body haemolytic anaemia and non-Heinz body haemolysis may rarely occur (Gardner & Bargen, 1964). Although there was a slight fall in haemoglobin in the present case, no evidence of haemolysis was apparent.…”

Section: Discussioncontrasting

confidence: 46%

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Agranulocytosis associated with sulphasalazine therapy

Cochrane

Atkins

Ehsanullah

1973

Postgraduate Medical Journal

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Summary A case report of a patient with agranulocytosis associated with sulphasalazine therapy is described. Recovery followed supportive therapy and withdrawal of the drug. Investigations including tests for leucocyte antibodies, the presence of which might have suggested an immunological cause for the drug reaction, were negative; an acetylation study, however, characterized the patient as a ‘slow’ acetylator phenotype, suggesting that the drug reaction was more likely to have been toxic in nature. It is suggested that acetylation studies be performed in patients who have previously shown serious side effects to sulphasalazine to assess the incidence of ‘slow’ acetylators.

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Section: Discussioncontrasting

confidence: 46%

“…Although there was a slight fall in haemoglobin in the present case, no evidence of haemolysis was apparent. Thrombocytopenia (Thirkettle, Gough & Read, 1963), methaemoglobinaemia and sulphaemoglobinaemia (Gardner & Bargen, 1964) have also been noted with sulphasalazine treatment.…”

Section: Discussionmentioning

confidence: 99%