Hemolytic Anemia in Native Valve Infective Endocarditis

Huang, Hsuan-Li; Lin, Fun‐Chung; Hung, Kuo‐Chun; Wang, Po‐Nan; Wu, Delon

doi:10.1253/jcj.63.400

Cited by 12 publications

(10 citation statements)

References 10 publications

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“…There are reports of fragmentation hemolysis related to acute infective endocarditis of the native valve (4,5). The present case was not comparable with previous reports because the patient had had infective endocarditis 16 years previously.…”

Section: Discussioncontrasting

confidence: 86%

Intravascular Hemolysis in Aortic Stenosis

et al. 2004

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A 67-year-old woman with rheumatic aortic stenosis for 20 years was admitted to our hospital. Although she had no overt symptoms, she had severe aortic valve stenosis with a transvalvular pressure gradient of more than 150 mmHg. She had also been suffering from anemia and mild chronic renal failure. A peripheral blood smear showed numerous fragmented erythrocytes. Hemoglobin was 8.4 g/dl, lactate dehydrogenase was 316 IU/l, haptoglobin was less than 7.3 mg/dl, and hemosiderinuria was evident. We diagnosed intravascular hemolysis related to aortic stenosis. After we performed an aortic valve replacement, fragmentation on the peripheral blood smear dramatically disappeared.

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Section: Discussioncontrasting

confidence: 86%

Intravascular Hemolysis in Aortic Stenosis

et al. 2004

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“…It was hypothesized that vegetation on the valves can apply shearing stress on RBC leading to fragmentation similar to valve‐related mechanical hemolytic anemia particularly prosthetic mitral valve regurgitation 5, 6, 7. The infectious microorganisms may also cause the production of anti‐erythrocyte antibodies by cross‐reaction with erythrocyte antigens, or by modification of the antigenicity of erythrocyte antigens or by unmasking antigens that are not normally available 5. Our case presentation was similar albeit with even more scant evidence.…”

Section: Discussion and Review Of Literaturementioning

confidence: 54%

“…Both mechanical hemolysis and autoimmune hemolysis have been described 2, 3, 4. Hsuan‐Li et al reviewed six cases of hemolytic anemia secondary to endocarditis; in all the cases, there was the presence of fragmented erythrocytes suggestive of intravascular hemolysis 5. Interestingly, multiple cases also demonstrated the co‐existing immune‐mediated mechanism, evidenced by the presence of spherocytes, splenomegaly, and a positive direct Coombs test 5.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…Hsuan‐Li et al reviewed six cases of hemolytic anemia secondary to endocarditis; in all the cases, there was the presence of fragmented erythrocytes suggestive of intravascular hemolysis 5. Interestingly, multiple cases also demonstrated the co‐existing immune‐mediated mechanism, evidenced by the presence of spherocytes, splenomegaly, and a positive direct Coombs test 5. It was hypothesized that vegetation on the valves can apply shearing stress on RBC leading to fragmentation similar to valve‐related mechanical hemolytic anemia particularly prosthetic mitral valve regurgitation 5, 6, 7.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…Interestingly, multiple cases also demonstrated the co‐existing immune‐mediated mechanism, evidenced by the presence of spherocytes, splenomegaly, and a positive direct Coombs test 5. It was hypothesized that vegetation on the valves can apply shearing stress on RBC leading to fragmentation similar to valve‐related mechanical hemolytic anemia particularly prosthetic mitral valve regurgitation 5, 6, 7. The infectious microorganisms may also cause the production of anti‐erythrocyte antibodies by cross‐reaction with erythrocyte antigens, or by modification of the antigenicity of erythrocyte antigens or by unmasking antigens that are not normally available 5.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

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