Hemolytic Anemia Associated with Thymoma in the Rabbit

Abstract

We report the presence of an hereditary hemolytic anemia in the X strain of rabbits. This condition is rapidly fatal to both sexes with a mean survival time of 4.75 months. In rare protracted cases it is associated with thymic hyperplasia and thymoma. Because autosomal recessive inheritance is indicated we have assigned the symbol ha to the gene responsible for development of the hemolytic anemia. The possibility exists that it is identical with the gene (Is) conferring susceptibility to lymphosarcoma in strain WH rabbits, since all affected animals in both strains have the same common ancestry in strain X. A common gene responsible for all conditions may have phenotypic expressions which are dependent on the host genotype. Breeding experiments are in progress to test this hypothesis.

Detection of Antibodies against Pasteurella multocida Using Immunohistochemical Staining in an Outbreak of Rabbit Pasteurellosis.

“…In the present study, rabbits naturally infected with P.multocida showed severe clinical signs and acute purulent pneumonia with serositis. The histopathological features of P.multocida infection in these rabbits correlated well with those reported in the literature [7][8][9].…”

“…There are many reports of pneumonia in rabbits induced by P.multocida [7][8][9]. In the present study, rabbits naturally infected with P.multocida showed severe clinical signs and acute purulent pneumonia with serositis.…”

“…is an important causal agent of snuffles, pneumonia, otitis media, abscess formation and conjunctivitis in rabbits [4,8,9], and these diseases are prevalent in rabbit colonies throughout the world. The clinical and pathological features of the diseases have been reported previously by many researchers [7][8][9].…”

“…The clinical and pathological features of the diseases have been reported previously by many researchers [7][8][9]. However, there is little information on time course change of IgM and IgG antibody responses in rabbits naturally infected with P.multocida.…”

Thymoma‐associated exfoliative dermatitis in a rabbit

“…Exfoliative dermatitis (ED) in rabbits can be associated with many aetiologies: malnutrition, dermatophytosis, ectoparasites, Malassezia dermatitis, sebaceous adenitis and epitheliotropic lymphoma 1 . Thymomas in rabbits are uncommon 2–6 . They have been associated with haemolytic anaemia, dyspnoea, swelling of the head, exophthalmos and hypercalcaemia.…”