Hemolytic Anemia and Pyruvate Kinase Deficiency in Pregnancy

Amankwah, Kofi; Dick, Barrett W.; Dodge, Steven T.

doi:10.1097/00006250-198003001-00013

Cited by 40 publications

(9 citation statements)

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“…Successful pregnancies and deliveries have been reported in women with PKD . Pregnancy is associated with increased hemolysis in some individuals; thus, regular transfusions may be necessary even in women who were transfusion‐independent before pregnancy.…”

Section: Current State Of Supportive Carementioning

confidence: 99%

“…No guidelines exist regarding indications for blood transfusion during pregnancy, and it is not clear whether splenectomy status or other factors affect the degree of hemolysis in pregnancy. The increased hemolysis observed during pregnancy abates soon after delivery . Women should be counseled regarding the potential for increased hemolysis during pregnancy, and the requirement for close follow up with both an obstetrician and hematologist .…”

Section: Current State Of Supportive Carementioning

confidence: 99%

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Erythrocyte pyruvate kinase deficiency: 2015 status report

et al. 2015

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Over the last several decades, our understanding of the genetic variation, pathophysiology, and complications of the hemolytic anemia associated with red cell pyruvate kinase deficiency (PKD) has expanded. Nonetheless, there remain significant gaps in our knowledge with regard to clinical care and monitoring. Treatment remains supportive with phototherapy and/or exchange transfusion in the newborn period, regular or intermittent red cell transfusions in children and adults, and splenectomy to decrease transfusion requirements and/or anemia related symptoms. In this article, we review the clinical diversity of PKD, the current standard of treatment and for supportive care, the complications observed, and future treatment directions.Am. J. Hematol. 90:825–830, 2015. © 2015 Wiley Periodicals, Inc.

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Section: Current State Of Supportive Carementioning

confidence: 99%

Section: Current State Of Supportive Carementioning

confidence: 99%

Erythrocyte pyruvate kinase deficiency: 2015 status report

et al. 2015

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“…While there have been few cases reported of pregnancy in women with pyruvate kinase deficiency, successful neonatal and maternal outcome is reported 10–16 . However, this is the first case reporting iron overload as a complication of the condition in pregnancy.…”

Section: Discussionmentioning

confidence: 88%

Pyruvate kinase deficiency in pregnancy complicated by iron overload

Dolan¹,

Ryan

Moohan

2002

BJOG

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“…Thus, patients exhibit greater tolerance to increasing oxygen demand than expected on the basis of the hemoglobin. Other authors recommend transfusions to maintain a hemoglobin concentration of 7-8mg/d L or more (10,11,12).…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, while all three reported pregnancies without transfusion (9,12) resulted in growth-restricted fetuses, so did two of three pregnancies managed with transfusions (11). Pregnant women with pyruvate kinase deficiency should be monitored for hypertensive disorders, observed in three of seven reported cases (10,12). Finally, it is recommended monthly to perform ultrasonographic assessments of fetal growth after 20 weeks, because 5 of 6 affected pregnancies experienced intrauterine growth restriction.…”

Section: Discussionmentioning

confidence: 99%