HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide

Shin, Na‐Rae; Kim, Sung Hoon; Ko, Je‐Won; Park, Sung-Hyeuk; Lee, In-Chul; Ryu, Jung-Min; Kim, Jong-Choon; Shin, In‐Sik

doi:10.5625/lar.2017.33.1.40

Cited by 15 publications

(16 citation statements)

References 32 publications

(35 reference statements)

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“…Mechanisms of anti-inflammatory action of herbal preparations in COPD are being actively studied. A herbal preparation HemoHIM reduced the inflammatory cell count and levels of TNF-α, IL-6, and IL-1β, in the broncho-alveolar lavage fluid [24]. Green tea consumption was associated with positive dynamics of expiratory function parameters [25].…”

Section: Discussionmentioning

confidence: 93%

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Kirichenko

Sobenin

Markina

et al. 2020

Biology

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Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respiratory function, and exacerbation frequency in 60 patients with moderate severity of COPD. Inflaminat is a combination of natural ingredients black elder (Sambucus nigra L.) berries, violet (Viola tricolor L.) herb, and calendula (Calendula officinalis L.) flowers. The preparation has been previously demonstrated to possess anticytokine and anti-inflammatory effects in experimental studies. In present study, COPD dynamics were evaluated by means of BCSS (Breathlessness, Cough, and Sputum Scale) and spirometry tests. It was shown that 6-months Inflaminat administration led to significant decrease of BCSS points from 3.0 ± 0.6 to 1.9 ± 0.7, (p = 0.002) as well as significant increase of FEV1 from 66 ± 18% to 73 ± 17%, (p = 0.042); there were no beneficial dynamics in placebo group. Side effects associated with preparation administration were not identified. The results of the study suggest that Inflaminat may be employed in treatment of patients with moderate severity of COPD, since it has a positive effect on COPD symptoms according BCSS and indicators of respiratory function FEV1.

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Section: Discussionmentioning

confidence: 93%

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Kirichenko

Sobenin

Markina

et al. 2020

Biology

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“…The mouse model for lung inflammation induced by CS and LPS was described in a previous report [ 2 ]. Briefly, CS was generated from 3R4F research cigarettes (Kentucky reference cigarette, University of Kentucky, Lexington, KY, USA) containing 11.0 mg of total particulate matter, 9.4 mg of tar, and 0.76 mg of nicotine per cigarette.…”

Section: Methodsmentioning

confidence: 99%

“…The test chemicals were dissolved in corn oil, and daily application volumes (5 mL/kg) were calculated based on the most recently recorded body weight of the individual animal. ROF is a phosphodiesterase-4 inhibitor and is recommended for the remedy of COPD [ 2 ].…”

Section: Methodsmentioning

confidence: 99%

“…BALF was collected as described previously [ 2 ]. To count inflammatory cells, BALF was stained with Diff-Quik ® staining reagent (IMEB Inc., Deerfield, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

“…It is closely associated with the development of various diseases and is particularly regarded as the most important cause of chronic obstructive pulmonary disease (COPD) [ 1 ]. CS is composed of numerous chemicals that can cause various pathological conditions, such as oxidative stress and inflammation [ 2 ]. Exposure to CS increases the recruitment of inflammatory cells into lung tissues [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Preventive Effect of Garlic Oil and Its Organosulfur Component Diallyl-Disulfide on Cigarette Smoke-Induced Airway Inflammation in Mice

Jeong

Kwon

et al. 2018

Nutrients

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Garlic (Allium sativum) has traditionally been used as a medicinal food and exhibits various beneficial activities, such as antitumor, antimicrobial, hypolipidemic, antiarthritic, and hypoglycemic activities. The aim of this study was to explore the preventive effect of garlic oil (GO) and its organosulfur component diallyl disulfide (DADS) on cigarette smoke (CS)-induced airway inflammation. Mice were exposed to CS daily for 1 h (equivalent to eight cigarettes per day) for two weeks, and intranasally instilled with lipopolysaccharide (LPS) on day 12 after the initiation of CS exposure. GO and DADS were administered to mice by oral gavage, both at rates of 20 and 40 mg/kg, for 1 h before CS exposure for two weeks. In the bronchoalveolar lavage fluid, GO and DADS inhibited the elevation in the counts of inflammatory cells, particularly neutrophils, which were induced in the CS and LPS (CS + LPS) group. This was accompanied by the lowered production (relative to the CS + LPS group) of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. Histologically, GO and DADS inhibited the CS- and LPS-induced infiltration of inflammatory cells into lung tissues. Additionally, GO and DADS inhibited the phosphorylation of extracellular signal-regulated kinase and the expression of matrix metalloproteinase-9 in the lung tissues. Taken together, these findings indicate that GO and DADS could be a potential preventive agent in CS-induced airway inflammation.

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Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4‐mediated NF‐κB signaling pathway

Wang

et al. 2023

Immunity Inflam & Disease

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Introduction Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation that predominantly affects the lung and peripheral airways. Previous investigation has underlined the efficacy of luteolin in the treatment of inflammation‐related symptoms. Accordingly, our study concentrates on unveiling the effect of luteolin on COPD. Methods Mice or A549 cells were treated with cigarette smoke (CS) to establish COPD models in vivo and in vitro. Then, the serum and bronchoalveolar lavage fluid of mice were harvested. The lung tissues of mice were subjected to hematoxylin‐eosin staining to observe the degree of damage. The inflammation and oxidative stress factors level were calculated via enzyme‐linked immunosorbent assay and quantitative real‐time polymerase chain reaction. The expressions of nuclear factor‐kappa B (NF‐κB) pathway‐related factors were detected by Western blot. Results In in vivo experiments, CS treatment reduced the weight of mice and promoted lung tissue damage, while luteolin attenuated the effect of CS on the mice. Moreover, luteolin inhibited the inflammation factors level, oxidative stress, and NADPH oxidase 4 (NOX4)‐mediated NF‐κB signaling pathway in CS‐induced COPD mice. Similar results were obtained in in vitro experiments that luteolin alleviated CS‐induced inflammation, oxidative stress, and NOX4‐mediated NF‐κB signaling pathway activation in CS‐treated A549 cells. Besides, NOX4 overexpression offset the impacts of luteolin on the CS‐induced A549 cells. Conclusion Luteolin alleviates inflammation and oxidative stress in COPD via NOX4‐mediated NF‐κB signaling pathway, which provides a theoretical basis for the treatment of COPD with luteolin.

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HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide

Cited by 15 publications

References 32 publications

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Preventive Effect of Garlic Oil and Its Organosulfur Component Diallyl-Disulfide on Cigarette Smoke-Induced Airway Inflammation in Mice

Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4‐mediated NF‐κB signaling pathway

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