Hemoglobin Variants in Northern Thailand: Prevalence, Heterogeneity and Molecular Characteristics

Panyasai, Sitthichai; Fucharoen, Goonnapa; Fucharoen, Supan

doi:10.1089/gtmb.2015.0182

Cited by 15 publications

(21 citation statements)

References 23 publications

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“…Fifth, lifestyle modification should also be detected, especially those who were diagnosed several years previously, because lifestyle could also impact suboptimal glycemic control. Last, very few people in northern Thailand carry Hb variants [ 48 ], which might impact the interpretation of HbA1C. Thus, any further research should be aware of these points.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of suboptimal glycemic control among patients with type 2 diabetes mellitus in northern Thailand: A hospital-based cross-sectional control study

et al. 2022

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Background Suboptimal glycemic control among patients with type 2 diabetes mellitus (DM) is a significant public health problem, particularly among people living with poor education and economic statuses, including those with a unique dietary culture. This study aimed to estimate the prevalence and identify the factors associated with suboptimal glycemic control among patients with type 2 DM during the coronavirus disease-2019 (COVID-19) pandemic. Methods A hospital-based cross-sectional study was used to elicit information from DM patients attending six hospitals located in Chiang Rai Province, northern Thailand, between February and May 2021. A validated questionnaire and 5 mL blood specimens were used as the research tools. Glycated hemoglobin (HbA1c) greater than 7.0% among DM patients at least two years after diagnosis was defined as suboptimal glycemic control. Chi-square tests and logistic regression were used to identify the associations between variables at the significance level α = 0.05. Results A total of 967 patients were recruited for this study; 54.8% 530 had suboptimal glycemic control, 58.8% were female, 66.5% were aged 50-69 years, and 78.5% were married (78.5%). Six variables were found to be associated with suboptimal glycemic control in multivariable logistic regression. Participants aged <49, 50-59, and 60-69 years had 3.32 times (95% CI = 1.99-5.53), 2.61 times (95% CI = 1.67-4.08), and 1.93 times (95% CI = 1.26-2.95) greater odds of having suboptimal glycemic control, respectively, than those aged ≥70 years. Married individuals had 1.64 times (95% CI = 1.11-2.41) greater odds of having suboptimal glycemic control than those ever married. Participants who consumed sticky rice had 1.61 times (95% CI = 1.19-2.61) greater odds of having suboptimal glycemic control than those who did not consume sticky rice in daily life. Participants who had been diagnosed with DM for 11-20 years and ≥21 years had 1.98 times (95% CI = 1.37-2.86) and 2.46 times (1.50-4.04) greater odds of having suboptimal glycemic control, respectively, than those who had been diagnosed ≤ 10 years. Participants who had experienced forgetting to take their medication had 2.10 times (95% CI = 1.43-3.09) greater odds of having suboptimal glycemic control than those who did not, and those who had their medical expenses covered by the national scheme had 2.67 times (95% CI = 1.00-7.08) greater odds of suboptimal glycemic control than those who self-paid. Conclusion Effective health interventions to control blood glucose among DM patients during ongoing treatment are urgently required. The interventions should focus on patients aged less than 69 years, marital status, forgetting to take their medication, and a longer time since diagnosis, including reducing their sticky rice consumption. The effects of copayments should also be considered.

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Section: Discussionmentioning

confidence: 99%

Prevalence and predictors of suboptimal glycemic control among patients with type 2 diabetes mellitus in northern Thailand: A hospital-based cross-sectional control study

et al. 2022

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“…6 Approximately 20% to 30% of the Thai population are carriers of alpha-thalassemia. 1 In the northern Thai population, the estimated prevalence of deletional and nondeletional Hb H disease is 13.6:1000 and 1.6:1000, This Report Fucharoen and Fucharoen 9 Panyasai et al 10 Panyasai et al…”

Section: Discussionmentioning

confidence: 95%

“…The hematologic manifestation is more severe than those seen in cases with deletional Hb H disease and heterozygous Hb Tak in the previous reports. 9,10 The effects of other genes on the severity of anemia are not found by whole-exome sequencing analysis.…”

Section: Discussionmentioning

confidence: 99%

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Coinherited Hemoglobin H/Constant Spring Disease and Heterozygous Hemoglobin Tak Causing Severe Hemolytic Anemia in a Thai Boy

Choed-Amphai

Phusua

Ittiwut

et al. 2020

Journal of Pediatric Hematology/Oncology

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Hemoglobin (Hb) H/Constant Spring disease is a common nondeletional Hb H disease, typically causing a more severe phenotype than the deletional Hb H disease counterpart. Hb Tak, resulting from a dinucleotide insertion (+AC) at codon 146 of beta-globin gene, has an increased oxygen affinity and usually presents with polycythemia. We studied a case of a 4-year-old Thai boy with a severe, early-onset anemia. To our knowledge, he is the first reported patient with Hb H/Constant Spring disease and heterozygous Hb Tak. Trio–whole-exome sequencing does not identify other genetic variants that may contribute to the severity of anemia. The observation suggests that coinherited Hb H/Constant Spring and heterozygous Hb Tak lead to severe hemolytic anemia.

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“…However, the compound heterozygote of Hb New York and Hb S presented complication associated to sickling [4]. Even though Hb S is very rare in Thailand, the b-thalassemia and other b-globin variants such as Hb E, Hb Hope, and Hb Tak are highly frequent [5]. The compound heterozygote of Hb New York and b-thalassemia or these b-globin variants may lead a clinical picture as thalassemia intermedia with mild anemia.…”

Section: Images In Hematologymentioning

confidence: 99%

Detection of Hemoglobin New York [β113 (G15) Val→Glu, GTG>GAG] in a Thai Woman by Capillary Electrophoresis

Panyasai

Pornprasert

2016

Indian J Hematol Blood Transfus

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Hemoglobin (Hb) New York [b113 (G15) Val?Glu, GTG[GAG] is a very rare b-chain variant found in Thailand. This variant is often missed by routine laboratory testing because Hb New York and Hb A have the identical retention time on high performance liquid chromatography. We reported here for the first time that the detection of Hb New York in a Thai woman by using capillary electrophoresis (CE). A peak of Hb New York located ahead of Hb A at the electrophoretic zone 11 with a level of 42.8 %. The DNA sequencing revealed the GTG[GAG mutation at codon 113 for Hb New York on one allele of b-globin gene. Therefore, the CE has a high efficiency to prevent the misinterpretation of hemoglobin analysis in patients who are heterozygote of this variant.

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Hemoglobin Variants in Northern Thailand: Prevalence, Heterogeneity and Molecular Characteristics

Abstract: The prevalence and molecular heterogeneities of the Hb variants found in this large cohort of the northern Thai people's should prove useful in developing a screening program, and for the performance of additional population genetics studies of hemoglobinopathy in the region.

Cited by 15 publications

References 23 publications

Prevalence and predictors of suboptimal glycemic control among patients with type 2 diabetes mellitus in northern Thailand: A hospital-based cross-sectional control study

Prevalence and predictors of suboptimal glycemic control among patients with type 2 diabetes mellitus in northern Thailand: A hospital-based cross-sectional control study

Coinherited Hemoglobin H/Constant Spring Disease and Heterozygous Hemoglobin Tak Causing Severe Hemolytic Anemia in a Thai Boy

Detection of Hemoglobin New York [β113 (G15) Val→Glu, GTG>GAG] in a Thai Woman by Capillary Electrophoresis

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