Hemoglobin Regeneration Following Oral Administration of Chelated Iron

Chelation in Nutrition, Chelation as a Basic Biological Mechanism

“…They were unable to demonstrate any significant differences in the chelated iron metabolism compared to ferrous sulfate. Seeberg et al (25) reported on the hemoglobin regeneration in iron deficient rats following Fe EDTA. These authors found the chelated iron to be an effective oral iron source.…”

“…It has not been clear from previous studies whether chelated iron may be absorbed as such from the gastrointestinal tract or must first be dissociated from the carrier. Seeberg et al (25) suggested that dissociation of the iron chelate was a preliminary step to absorption. The evidence of the present study, however, establishes that part, at least, of the oral chelated iron appears in the urine in both normal and anemic rats and rabbits.…”

Iron Preparations for Anaemia

“…Perhaps for the same reason gastro-intestinal intolerance was greater in the patients taking chelate. Jennison (1958) found ferrous aminoacetosulphate (" plesmet ") more effective and less toxic than ferrous gluconate when given to pregnant women with iron deficiency, but studies with other chelates (Seeberg et al, 1954;Will and Vilter, 1954;Franklin et al, 1958) appear to show that this type of compound is in general no better absorbed or tolerated than similar doses of ferrous sulphate. There therefore seems to be no great advantage to be gained from the use of chelates in the treatment of most patients with iron deficiency.…”