Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Prognosis of Patients with Primary Hepatocellular Carcinoma

Abstract

Background The prognostic value of the hemoglobin/red blood cell distribution width ratio in primary hepatocellular carcinoma remains unknown. This study aimed to analyze the correlation between hemoglobin/red blood cell distribution width ratio and hepatocellular carcinoma prognosis. Material/Methods Medical records of hepatocellular carcinoma patients were analyzed retrospectively. The hemoglobin/red blood cell distribution width ratio cut-off value was determined as 0.987 by receiver operating characteristic curve analysis. Patients were divided into high- and low-level groups, and the clinical data were compared. The correlation among the ratio levels, progression-free survival, and overall survival was measured with univariate and multivariate Cox regression analyses. The prognostic utility of the ratio combined with alpha-fetoprotein was analyzed using Kaplan-Meier survival curves and log-rank detection, and the correlation between the ratio and tumor staging was studied using one-way analysis of variance. Results This study included 252 patients. Sex, smoking and alcohol consumption history, body mass index, surgery, staging, platelet/lymphocyte ratio, and hemoglobin/red blood cell distribution width ratio were associated with progression-free and overall survival ( P <0.05). The ratio, alpha-fetoprotein, hemoglobin, staging, and surgery were independent risk factors for progression-free survival ( P <0.05), and the ratio, alpha-fetoprotein, hemoglobin, body mass index, HBsAg, staging, and surgery were independent risk factors for overall survival ( P <0.05). Patients with low ratio levels and high alpha-fetoprotein levels had the worst prognosis. Conclusions Low hemoglobin/red blood cell distribution width ratio levels are associated with poor patient prognosis and are potential tumor prognosis markers.

Hepatoprotective Effect Assessment of C-Phycocyanin on Hepatocellular Carcinoma Rat Model by Using Photoacoustic Spectroscopy

“…HCC is one of the most vascular solid tumors, where several studies have shown anemia as a consequence of cytokine-mediated disorder, leading to reduced cell production, the rate of blood flow, microcirculation, and hemoglobin (Hb) concentration. 45 Thus, an important factor for the worsened prognosis of HCC is lower Hb levels could be due to the tumor hypoxia caused by anemia. The present study found that the oxygen–hemoglobin interaction, and various cellular events such as an oxidative cell environment and cell viability, are related to differences in the optical absorption spectra of whole blood where different absorption bands, such as the Soret band (417–420 nm), β and α, and the absorption valley at 513 nm.…”

Association between haemoglobin-to-red blood cell distribution width ratio at admission and all-cause mortality in adult patients with sepsis in an intensive care unit: a secondary analysis of the MIMIC-IV database

“…Our study expands this scope to include a broader demographic of patients with sepsis, diverging from the narrower focus on those with AF or SAE. Prior research has associated low HRR levels with decreased long-term survival in individuals with cancer or heart disease,13 14 19–21 suggesting that HRR at ICU admission might serve as a novel prognostic indicator for patients who are critically ill. Furthermore, our RCS analysis demonstrates a non-linear association between HRR and all-cause mortality, indicating that mortality rates decline with increasing HRR up to a threshold of 7.22, beyond which HRR does not influence mortality rates.…”

Clinical Significance of the Combination of Serum HE4 Levels, Hemoglobin-to-Red Cell Distribution Width Ratio, and CT Imaging for the Pretreatment Assessment of Adnexal Masses

“…The HRR is a prognostic marker for various malignant tumors [17][18][19][20][21]. In a meta-analysis by Chi et al, a low HRR was associated with an increased risk of all-cause mortality (hazard ratio [HR] 2.29) and disease progression or relapse (HR 2.19).…”

“…Red cell distribution width (RDW) predicts ovarian cancer (OC) with an SE and SP of 76.7% and 70.3%, respectively [16]. Recently, the Hb-to-RDW ratio (HRR) has been reported to be a prognostic marker for malignant tumors, including head and neck cancer, lung cancer, esophageal cancer, gastric cancer, hepatoma, renal cell carcinoma, bladder cancer, and malignant lymphoma [17][18][19][20][21]. Additionally, the diagnostic efficacy of HRR for breast, nasopharyngeal, and lung cancers has been reported [17,22,23].…”