Hemoglobin M Saskatoon (α₂β²63(E7) His→Tyr) in an Algerian Family

C to T transition at the first nucleotide of codon 63 of the β-globin gene corresponding to hemoglobin M-Saskatoon in an Indonesian boy

“…In malaria endemic areas as Indonesia, three helnoglobinopathies including ~-and ~-thalassemias and sickle cell anemia are very common genetic diseases since they confer resistance to malarial infection. In contrast to these hemoglobinopathies, the hemoglobinopathy of Hb M-Saskatoon has been reported to be rare in black people, although a case has been reported in Africa (Arbane-Dahmane et aL, 1985). In the present study we failed to identify the same mutation in group of 50 Indonesia patients with thalassemia.…”

“…Hb M-Saskatoon has been found in Germany, Canada, Britain, the United States, France, Denmark, Norway, Poland, Italy, South Africa, Japan, the Soviet Union (Bunn and Forget, 1986), and Algeria (Arbane- Dahmane et al, 1985). The various exotic names that have been applied to Hb M-Saskatoon provide further testimony to the world-wide distribution of these variants.…”

First Observation of Hemoglobin M Saskatoon (�63 (E7) His>Tyr(C-T)) in the Iraqi Population

“…Hemoglobin M Saskatoon (ß63 His>Tyr(C-T)) is a rare hemoglobin variant that was first reported in Japan, fol- lowed by the US, Indonesia, Algeria, Russia, India, and Germany [1,2,3,4,5,6,7,8]. It was also reported in combination with another variant—Hb Hamilton [9]; however, it has yet to reported in the Turkish population [10,11].…”