Hemoglobin Kirklareli [Α2 59(E7) His&gt;Leu; HBA2:c.176A&gt;T] in a Brazilian child with severe dyspnea and low O2 saturation

Pedroso, Gisele Audrei; Fernándes, Paula Teíxeira; Jorge, Susan E.; Nascimento, P. H.; Lima, Priscila Carneiro Moreira; Grigoleto, Marcela Regina Paganuchi; Albuquerque, Dulcinéia Martins; Santos, Magnun Nueldo Nunes; Costa, Fernando Ferreira; Toro, Adyléia Aparecida Dalbo Contrera; Sonati, M.F.

doi:10.1007/s00277-019-03839-z

Cited by 2 publications

(4 citation statements)

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“…As indicated by the GO enrichment analysis that the haem binding was strongly involved in the ZTO‐related dyspnoea, we decided to investigate the interaction between ZTO and Hb which is a key protein mainly responsible for carrying oxygen, with haem as the key component binding to the oxygen. Notably, it has been reported that the disturbed Hb could be strongly associated with the occurrence of dyspnoea in clinic, which provides a potential clue to understand the mechanisms underlying the ZTO‐induced dyspnoea 12 . And UV–visible absorption measurement is an effective approach to investigate the structure change of protein and to understand the ligand‐protein complex formation.…”

Section: Resultsmentioning

confidence: 99%

“…Importantly, it was noticed that the patients with structural mutation in Hb were suffering from a decreased oxygen affinity, with clinical manifestation as dyspnoea, lower oxygen saturation, cyanosis and tissue hypoxia. 12,37,38 Thus, a disturbed Hb-based mechanism was proposed to elucidate the ZTO-induced dyspnoea. Additionally, there are other cases of drug-induced dyspnoea which are related to the perturbed Hb.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, our study suggested a potential perturbation on the structure of haem by ZTOI. Importantly, it was noticed that the patients with structural mutation in Hb were suffering from a decreased oxygen affinity, with clinical manifestation as dyspnoea, lower oxygen saturation, cyanosis and tissue hypoxia 12,37,38 . Thus, a disturbed Hb‐based mechanism was proposed to elucidate the ZTO‐induced dyspnoea.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, it has been reported that the disturbed Hb could be strongly associated with the occurrence of dyspnoea in clinic, which provides a potential clue to understand the mechanisms underlying the ZTO-induced dyspnoea. 12 And UV-visible absorption measurement is an effective approach to investigate the structure change of protein and to understand the ligand-protein complex formation. It is well known that Hb has several characteristic absorption peaks.…”

Section: Ztoi Decreased the Peak Intensity Of Soret Band Of Hbmentioning

confidence: 99%

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Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Yang

Wang

et al. 2022

Basic Clin Pharma Tox

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Zedoary turmeric oil (ZTO) has been widely used in clinic. However, the unpleasant induced dyspnoea inevitably impedes its clinical application. Thus, it is urgent to elucidate the mechanism underlying the ZTO‐induced dyspnoea. In this study, network pharmacology was firstly performed to search the clue of ZTO‐induced dyspnoea. The key target genes of ZTO‐induced dyspnoea were analysed using GO enrichment analysis and KEGG pathway analysis. GO analysis suggested that haem binding could be a key molecular function involved in ZTO‐induced dyspnoea. Hence, the haemoglobin (Hb) was focused for its oxygen‐carrying capacity with haem as its critical component binding to the oxygen. Ultraviolet–visible absorption spectrum indicated that the ZTO injection (ZTOI) perturbed the Soret band of Hb, suggesting an interaction between ZTO and Hb. GC–MS analysis revealed that β‐elemene, germacrone, curdione and furanodiene were main components of ZTOI. Molecular docking was used to illustrate the high affinity between representative sesquiterpenes and Hb, which was finally confirmed by surface plasmon resonance, suggesting their potential roles in dyspnoea by ZTO. Following a network pharmacology‐driven strategy, our study revealed an intervened Hb‐based mechanism underlying the ZTO‐induced dyspnoea, providing a reference for elucidating mechanism underlying adverse drug reactions of herbal medicines in clinic.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ztoi Decreased the Peak Intensity Of Soret Band Of Hbmentioning

confidence: 99%

See 2 more Smart Citations

Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Yang

Wang

et al. 2022

Basic Clin Pharma Tox

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Hb H disease associated with compound heterozygosity for -- ^SEA deletion and a novel alpha globin chain variant ( HBA2 :c.175C>A) on the distal histidine in a Chinese family

Sun,

Lou,

Xinghe

et al. 2024

Hematology

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Hemoglobin Kirklareli [Α2 59(E7) His>Leu; HBA2:c.176A>T] in a Brazilian child with severe dyspnea and low O2 saturation

Cited by 2 publications

References 5 publications

Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Hb H disease associated with compound heterozygosity for -- ^SEA deletion and a novel alpha globin chain variant ( HBA2 :c.175C>A) on the distal histidine in a Chinese family

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Hemoglobin Kirklareli [Α2 59(E7) His>Leu; HBA2:c.176A>T] in a Brazilian child with severe dyspnea and low O2 saturation

Cited by 2 publications

References 5 publications

Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil

Hb H disease associated with compound heterozygosity for -- SEA deletion and a novel alpha globin chain variant ( HBA2 :c.175C>A) on the distal histidine in a Chinese family

Contact Info

Product

Resources

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Hb H disease associated with compound heterozygosity for -- ^SEA deletion and a novel alpha globin chain variant ( HBA2 :c.175C>A) on the distal histidine in a Chinese family