Hemoglobin E: Distribution and population dynamics

Flatz, G.

doi:10.1007/bf00273124

Cited by 78 publications

(52 citation statements)

References 83 publications

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“…With these few investigations it became an interesting area of research in Northeast India just within a decade of its discovery (Chernoff et al 1954;Itano et al 1954). Initially a strong relationship between HbE and Austro-Asiatic linguistic groups of Southeast Asia was pointed out by Flatz (1967) and he hypothesized that high frequency of HbE could also be expected in the population groups of Northeast India which have ethnic relation with Southeast Asia. In view of this observed association Das et al (1971) and later Flatz et al (1972) veered their concentration towards three population groups.…”

Section: Hemoglobin E Research In Northeast Indiamentioning

confidence: 99%

“…It showed frequencies of HbE gene little above 0.50. This observation drew special attention at that time in view of the fact that so far very little or no HbE had been detected in any Tibeto-Burman groups of South-East Asia (Flatz 1967). After that the most significant observation was the finding of high prevalence of HbE in the other Tibeto-Burman speakers including Sonowal Kacharis (0.549), Boro Kacharis (0.645), Garos (0.499), Rabhas (0.535), Lalungs (0.447) and Rajbanshis (0.350), where the percentage of HbAE ranges from 37.0% to 55% and HbEE ranges from 15.0% to 31.0%.…”

Section: Hemoglobin E Research In Northeast Indiamentioning

confidence: 99%

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Hemoglobin E in Northeast India: A review on its origin, distribution, migration and health implication

Sikdar

2016

Anthropological Review

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A systematic review of the studies on hemoglobin E in Northeast India has been carried out to understand the magnitude of research undertaken on this aspect during the last seven decades. Owing to the high prevalence of hemoglobin E in this part of India different authors have studied this hemoglobin from different perspectives and found conflicting results. However a systematic review of such studies is lacking from a holistic point of view. Most of the epidemiological, in vitro as well as in vivo studies show signatures of selection with this hemoglobin locus. However, how this polymorphism is maintained at different rates at different geographical region is still a matter of contention. This review will fill the gap from all perspectives starting from the frequency distribution of hemoglobin E and its spread in different parts of Northeast India, its relationship with malaria hypothesis, the population migration, population affinity and most importantly the health implication arising out of it. A probable origin of hemoglobin E among an Austroasiatic population of Northeast India has been postulated with the help of advance molecular anthropological knowledge like the deep rooted markers of mt DNA and Y-chromosome haplotypes.

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Section: Hemoglobin E Research In Northeast Indiamentioning

confidence: 99%

Section: Hemoglobin E Research In Northeast Indiamentioning

confidence: 99%

Hemoglobin E in Northeast India: A review on its origin, distribution, migration and health implication

Sikdar

2016

Anthropological Review

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“…This mutant, although polymorphic and carried by an estimated 30 million individuals in Southeast Asia, is rare elsewhere. In a large area involving portions of Laos, Cambodia, Thailand, and their mutual borders, the gene for PE exhibits its highest frequency and reaches an incidence of up to 55% among the Khmer people in Sarim and around the ancient temple of Angkor Wat (2). The gene frequency decreases concentrically from this area, with frequencies of 10-20% in Western Thailand, Burma, Southern Vietnam, and Sri Lanka.…”

Section: Introductionmentioning

confidence: 99%

Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes

Nagel¹,

Raventós-Suárez²,

Fabry³

et al. 1981

J. Clin. Invest.

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“…An estimated 30 million people may carry HbE gene in this region. 4 From the mainland, the gene spread southward to parts of Indonesia but the incidence is low in Indian subcontinent to the West and in China to the Northeast. 1 In Bangladesh, the prevalence of HbE gene is not studied but it is expected to be the same of India where an average HbE gene frequency has been found to be 10.9% in Northeastern states of India.…”

Section: Introductionmentioning

confidence: 99%

Compound heterozygosity for hemoglobin D and hemoglobin E

Rahman¹,

Khan²,

Begum³

et al. 2016

Bangabandhu Sheikh Mujib Medical University Journal

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<p>We present two cases of compound heterozygous state for hemoglobin (Hb) D and HbE who reported to the hospital for fever and incidentally found moderate microcytic hypochromic anemia. Later on they were investigated by capillary hemoglobin electrophoresis. Capillary Hb electrophoresis revealed compound heterozygous state for hemoglobin D and hemoglobin E. On family screening, father of one patient turned out to be HbD trait and mother as HbE trait. Due to unavailability of parents and siblings of other patient, family screening was not possible. Compound or double heterozygous state for HbD and HbE is rare. There are only six published reported cases of such double heterozygous state for HbD and HbE in Southeast Asia. Marriage between third degree relatives, which are more common among Muslims as well as inter caste marriages, common in some states of India have resulted into this compound heterozygous condition. Such double heterozygous case is clinically silent as compared to HbE/beta thalassemia or HbD/beta thalassemia.</p>

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Hemoglobin E: Distribution and population dynamics

Cited by 78 publications

References 83 publications

Hemoglobin E in Northeast India: A review on its origin, distribution, migration and health implication

Hemoglobin E in Northeast India: A review on its origin, distribution, migration and health implication

Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes

Compound heterozygosity for hemoglobin D and hemoglobin E

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