Hemoglobin Disorders in South India

Abstract

Cation exchange-high performance liquid chromatography (CE-HPLC) is increasingly being used as a first line of investigation for hemoglobinopathies and thalassemias. Together with a complete blood count, the CE-HPLC is effective in categorizing hemoglobinopathies as traits, homozygous disorders and compound heterozygous disorders. We carried out a one year study in Apollo Hospitals, Chennai (Tamil Nadu, South India) during which 543 abnormal chromatogram patterns were seen. The commonest disorder we encountered was β-thalassemia trait (37.9%), followed by HbE trait (23.2%), homozygous HbE disease (18.9%), HbS trait (5.3%), HbE β-thalassemia (4.6%), HbS β-thalassemia (2.5%), β-thalassemia major (2.3%), HbH (1.6%), homozygous HbS (1.4%), HbD trait (0.7%). The average value of HbA2 in β-thalassemia minor was 5.4%. β-thalassemia major had an average HbF of 88% and in HbH the mean A2 was 1.4%. Among the HbE disorders the HbA2 + HbE was 30.1% in the heterozygous state, 90.8% in the homozygous state and 54.8% in HbE β-thalassemia. In the sickle cell disorders, HbS varied from 30.9% in the trait to 79.9% in the homozygous state to 65.6% in HbS β-thalassemia.

HbA2 and Fetal haemoglobin in the diagnosis of Thalassemia and Hemoglobinopathies

“…This is comparable with other studies. [8,9,10,11] HbS trait was the second most common Hb disorder in the present study while HbE trait occupied the second position in other studies across the Indian population. [9,10] However Balgir and others have found Sickle cell anemia more common in Orissa, Eastern India.…”

“…[17] α Thalassemia and HbD were the less common Hb disorder in the present study similar to the other studies by Vani and others who reported 1.6% and 0.7% of these cases respectively. [8] The predominant feature in HbH disease is the presence of HbH ranging between 0.8% to 40% with normal or slightly reduced HbA2. [19] In the present study, HbH of 28.3% and HbA2 of 2.1% were observed.…”

“…A similar pattern has been described by Vani and others. [8] The other Hb disorders were single cases inadequate for comparison.…”

Spectrum of thalassemia and hemoglobinopathies in a tertiary care diagnostic center

“…[3] Rao et al [5] Singh et al [9] Patel et al [10] Alam et al [8] Chandra-Sekhar et al [11] Gupta et al [7] Mondal et al [12] Khera et al [13] HbS …”

Prevalence of the βSGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

“…Variations in the prevalence of the b S gene have been reported in various Scheduled Castes (SC) and Scheduled Tribes (ST) within different regions throughout India. There have been several previous studies on community screening in different communities for the b S gene but the number of individuals studied have been few; some studies have been hospital-based and the methodology used has not been uniform (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). While sickle cell disease is common among many different ethnic groups, high prevalence has been reported in three historically disadvantaged ethnic categories: the SC, the ST and Other Backward Class (OBC) groups in India .…”