Hemoglobin combined with triglyceride and ferritin in predicting non‐alcoholic fatty liver

Jiang, Yao‐Guang; Zeng, Jun; Chen, Bing

doi:10.1111/jgh.12580

Cited by 43 publications

(43 citation statements)

References 25 publications

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“…Our data are consistent with what has been reported previously [7][8][9][10][11]. However, the mechanism by which elevated HCT level is associated with NAFLD is not well understood; there are several possible explanations.…”

Section: Discussionsupporting

confidence: 83%

“…When HCT increases, blood viscosity increases. Blood flow rate and blood glucose supply to the muscles are reduced, resulting in insulin resistance [10]. In addition, higher blood viscosity is related to peripheral arterial resistance and blood pressure [15].…”

Section: Discussionmentioning

confidence: 99%

“…Hematological parameters including red blood cell (RBC) count, hematocrit (HCT), and hemoglobin (HGB) are also known to be independently associated with insulin resistance [7][8][9] and NAFLD [10] in diverse populations. Li et al [11] reported that the prevalence of NAFLD is positively associated with HCT levels in Hunan, China.…”

Section: Introductionmentioning

confidence: 99%

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Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Liu¹,

Liang²,

Qiu³

et al. 2017

J Metabolic Synd

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Non-alcoholic fatty liver disease (NAFLD) is recognized as a major cause of liver-related morbidity and mortality. The aim of this study was to examine the longitudinal association between baseline hematocrit (HCT) level and the development of NAFLD in Chinese adults. We performed a prospective cohort study of 2798 healthy Chinese adults without NAFLD at baseline. A Cox proportional hazards model was used to determine hazard ratios for NAFLD incidence in two groups determined by baseline hematocrit levels (group A, HCT <49%; group B, HCT ≥ 49%). During 10346.5 person-years of follow-up, 474 (16.9%) NAFLD cases developed between 2008 and 2012. After adjusting for multiple covariates and change in the covariates during the follow-up period, the hazard ratios (95% confidence interval) for NAFLD incidence when comparing group B with group A were 1.17 (1.03-1.31) and 1.70 (1.26-2.31), respectively (p<0.001). Conclusions:HCT level may be a predictor of the development of NAFLD in Chinese adults.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Liu¹,

Liang²,

Qiu³

et al. 2017

J Metabolic Synd

View full text Add to dashboard Cite

show abstract

“…In addition, HbA1c was 6.09+0.64 in fatty liver and 5.58+0.58 in control groups and showed significant difference (P=0.000). Similarly, in our study there was significant relation noted in urea (36 …”

Section: Result:-supporting

confidence: 64%

“…Similarly, significant difference was noticed in Hemoglobin (HGB) and platelet count among fatty liver and control group. In our study, hemoglobin level was significantly reduced than the control group, but various literature mentioned that high HGB significantly added to the risk of NAFLD [36]. Similarly, the platelet count is clinically important to predict the status of hepatic fibrosis in patients with chronic hepatic diseases [37].…”

Section: Discussion:-mentioning

confidence: 65%

Biochemical and Hematological Profile of Fatty Liver Patients From Western Nepal.

Tamrakar¹,

Nagila²,

Abdalhabib³

et al. 2017

IJAR

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Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity

Zhang

Cao

et al. 2020

Clinical Laboratory Analysis

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Background The association between serum ferritin and nonalcoholic fatty liver disease (NAFLD) in children with obesity is not clear. This study was designed to investigate whether serum ferritin can be an independent predictor for NAFLD. Methods According to the hepatic ultrasound results, a total of 347 children with obesity were enrolled in this study. Among them, 95 patients with NAFLD and 95 without NAFLD were matched for gender, age, blood pressure and body mass index, the odds ratios (OR) and 95% confidence intervals (CI) for the association of ferritin and the risk of NAFLD were analyzed. Results After propensity score matching, ferritin values of the patients with NAFLD were significantly higher than those without NAFLD group. Alanine aminotransferase and ferritin were strongly associated with NAFLD in multivariate stepwise logistic regression analysis. The medium and high levels of ferritin increased risk of NAFLD, and the adjusted ORs were 3.298 (95% CI:1.326‐8.204), 7.322 (95% CI:2.725‐19.574) across the ferritin concentration tertiles after adjustment for confounders. Ferritin was shown to be the best predictor for NAFLD with sensitivity and specificity of 60.0% and 77.9%, respectively, area under the curve was 0.733. Conclusion The results show that serum ferritin can usefully be considered as a predictor of NAFLD in children with obesity.

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Hemoglobin combined with triglyceride and ferritin in predicting non‐alcoholic fatty liver

Abstract: Our data suggest that HGB combined with TG and ferritin may serve as the indicator of predicting NAFLD.

Cited by 43 publications

References 25 publications

Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Association between Hematocrit Level and the Development of Non-Alcoholic Fatty Liver Disease in Chinese Adults: A 5-Year Study

Biochemical and Hematological Profile of Fatty Liver Patients From Western Nepal.

Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity

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