Hemoglobin A1c measurement for the diagnosis of Type 2 diabetes in children

Kapadia, Chirag; Zeitler, Philip

doi:10.1186/1687-9856-2012-31

Cited by 44 publications

(38 citation statements)

References 20 publications

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“…Recent studies question the validity of A1C in the pediatric population, especially among certain ethnicities, and suggest OGTT or FPG as more suitable diagnostic tests (33). However, many of these studies do not recognize that diabetes diagnostic criteria are based on long-term health outcomes, and validations are not currently available in the pediatric population (34). The ADA acknowledges the limited data supporting A1C for diagnosing type 2 diabetes in children and adolescents.…”

Section: Testing For Type 2 Diabetes and Prediabetes In Children Andmentioning

confidence: 99%

2. Classification and Diagnosis of Diabetes

2015

Diabetes Care

871

433

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Section: Testing For Type 2 Diabetes and Prediabetes In Children Andmentioning

confidence: 99%

2. Classification and Diagnosis of Diabetes

2015

Diabetes Care

871

433

View full text Add to dashboard Cite

“…This paradox is one shared by previous studies, which have shown poor agreement among the ADA’s three different prediabetes criteria (18, 21–23). All three measures are flawed in that they lack validation in the pediatric population (24), emphasizing the need to corroborate prediabetic measures in children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999–2014

et al. 2017

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Introduction Prediabetes is a reversible state of glycemic abnormalities that is frequently associated with obesity and the metabolic syndrome (MetS). There has been controversy over determining the most effective methods of determining prediabetes status in adolescents. We sought to investigate temporal trends in prediabetes prevalence among U.S. adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score. Methods We evaluated data from 5418 non-Hispanic-white, non-Hispanic-black, and Hispanic adolescents aged 12–19 participating in the National Health and Nutrition Examination Survey 1999–2014 with complete data regarding MetS and hemoglobin A1c (HbA1c). Prediabetes status was defined by American Diabetes Association (ADA) criteria: fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4%. MetS severity was assessed with a MetS-severity Z-score. Results Prevalence of prediabetes as defined by HbA1c abnormalities significantly increased from 1999–2014, while prevalence of prediabetes as defined by fasting glucose abnormalities showed no significant temporal trend. There were variations in these trends across different racial/ethnic groups. MetS Z-score was overall more strongly correlated with HbA1c, fasting insulin, and the homeostasis-model-of-insulin-resistance than was BMI Z-score. These correlations were true in each racial/ethnic group with the exception that in non-Hispanic-white adolescents, in whom the MetS Z-score was not significantly correlated to HbA1c measurements. Conclusion We found conflicting findings of temporal trends of U.S. adolescent prediabetes prevalence based on the ADA’s prediabetes criteria. The increasing prevalence of prediabetes by HbA1c assessment is concerning and raises the urgency for increased awareness and appropriate measures of prediabetes status among physicians and patients.

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“…Some studies question the validity of A1C in the pediatric population, especially among certain ethnicities, and suggest OGTT or FPG as more suitable diagnostic tests (52). However, many of these studies do not recognize that diabetes diagnostic criteria are based on long-term health outcomes, and validations are not currently available in the pediatric population (53). The ADA acknowledges the limited data supporting A1C for diagnosing type 2 diabetes in children and adolescents.…”

Section: Screening and Testing For Type 2 Diabetes And Prediabetes Inmentioning

confidence: 99%

2. Classification and Diagnosis of Diabetes:Standards of Medical Care in Diabetes—2018

2017

Diabetes Care

2,497

1,223

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The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.

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Hemoglobin A1c measurement for the diagnosis of Type 2 diabetes in children

Cited by 44 publications

References 20 publications

2. Classification and Diagnosis of Diabetes

2. Classification and Diagnosis of Diabetes

Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999–2014

2. Classification and Diagnosis of Diabetes:Standards of Medical Care in Diabetes—2018

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