Hemoglobin A1C is independently associated with severity and prognosis of brainstem infarctions

Li, Haiyan; Kang, Zhuang; Qiu, Wei; Hu, Biao; Wu, Ai-Min; Dai, Yongqiang; Luo, Jesse; Bingjun, Zhang; Lu, Zhengqi

doi:10.1016/j.jns.2012.02.024

Cited by 17 publications

(17 citation statements)

References 25 publications

(30 reference statements)

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“…Interestingly, a recent study indicated that the relationship between GHbA1c and macrovascular complications was not as significant as that of GHbA1c with microvascular complications and demonstrated no correlation with stroke (Penno et al, 2013). However, studies suggest that a higher GHbA1c level may be a serological marker to evaluate the severity and prognosis of acute brainstem infarctions (Li et al, 2012). In addition, an elevated GHbA1c level (>7.5%) was associated with an increased risk of all-cause mortality and a lower revascularization rate in elderly patients with new-onset diabetes (Twito et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes

et al. 2015

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ABSTRACT. Genetic factors play an important role in type 2 diabetes (T2D) complications. Alteration of cerebrovascular blood flow (CBF) is a direct result of cerebrovascular diseases. However, few studies have reported the role of genetics on CBF in patients with T2D. We investigated whether single-nucleotide polymorphisms (SNPs) in metabolic disease genes are associated with CBF in patients with T2D. CBF velocities of CBF were measured in 337 Han Chinese patients with T2D using transcranial Doppler sonography, with 54 cerebrovascular blood flow parameters documented. Fifty-two SNPs from 31 metabolic disease candidate genes were genotyped in patients. Quantitative allelic association and haplotype analyses were performed for candidate gene SNPs and CBF phenotypes. Spearman correlation was used to determine the relationship between CBF parameters and basic clinical characteristics, particularly, body mass index, lipids, fibrinogen, and GHbA1c. MYH9 gene SNPs (rs875726 and rs735853) may be associated with the peak velocity of the right-middle cerebral

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Section: Discussionmentioning

confidence: 99%

MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes

et al. 2015

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“…Ichikawa et al [11] found the lesion topography of BSIs differed between diabetic and non-diabetic patients, with a more frequent incidence of isolated pontine infarction in diabetic patients and the association of the basilar artery/internal carotid artery ratio with HbA 1c suggests that DM may affect each circulation differently [12]. Our recent description also showed HbA 1c is independently associated with severity and prognosis of BSIs [13]. In addition, it should be noted that our study found that the incidence of pons infarction was highest in BSI patients.…”

Section: Discussionmentioning

confidence: 70%

“…1) [13]. Acute BSIs were defined on DWI and categorized into midbrain, pons, medulla oblongata and overlapping regions.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, Ichikawa et al [11] found DM had an independent association with the incidence of BSIs and higher HbA 1c levels were independently correlated with the basilar artery/internal carotid artery ratio, indicating that DM has a different effect on the anterior and posterior circulation [12]. An elevated HbA 1c level has been reported to predict severity of stroke events and unfavorable outcome in patients with BSIs [13]. …”

Section: Introductionmentioning

confidence: 99%

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Ischemic Volumes and Early Neurologic Deterioration in Acute Brainstem Infarctions with Hemoglobin A<sub>1c</sub>

Qiu

et al. 2013

Eur Neurol

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Aim: To investigate the association of hemoglobin A_1c (HbA_1c) with acute diffusion-weighted imaging lesion volumes (DIV) and early neurologic deterioration (END) in brainstem infarctions (BSIs). Methods: 152 patients with acute BSIs were included in this study. The relationship between HbA_1c and DIV quartiles was examined. Data considered potentially associated with HbA_1c and END after admission and patients' symptomatic changes prior to admission were collected. Results: There was a significant correlation between HbA_1c (%) and DIV (Spearman ρ = 0.201, p = 0.013). The median HbA_1c (%) values for successive DIV quartiles (lowest to highest quartile) were as follows: 5.90, 6.35, 6.25, and 7.50 (p = 0.033). The incidence of diabetes mellitus had a significant association with DIV quartiles (p = 0.042). HbA_1c was signiﬁcantly associated with symptomatic progression prior to admission (p = 0.015). 29 patients developed END after admission. Age, HbA_1c, systolic blood pressure, and fibrinogen were signiﬁcantly associated with END. On logistic regression analysis, HbA_1c and fibrinogen proved to be independent variables. Conclusions: HbA_1c may be a possible predictor for ischemic severity, early deterioration of acute BSIs, and short-term prognosis. Long-term good glycemic control is very important in BSIs. Further studies are warranted to confirm these results.

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“…A recent study by Li et al, is one of the few studies systematically investigating the role of HbA1c on stroke outcome, regardless of a prestroke diagnosis of DM; their results show that elevated HbA1c level relates to stroke severity and poor prognosis in the whole study population; however, only patients with brainstem infarction were included in this study. 6,7 In a study conducted in Faisalabad in 2006, the frequency of raised HbA1c was 56.4% in patients presenting with ischemic stroke. 8 But another study conducted , the frequency of raised HbA1c was 13.2% in patients presenting with ischemic stroke.…”

Section: -4mentioning

confidence: 99%

ISCHEMIC STROKE; FREQUENCY OF RAISED HEMOGLOBIN A1c IN PATIENTS PRESENTING WITH ISCHEMIC STROKE

Rehman¹,

Alam²,

Rehman³

2017

TPMJ

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Hemoglobin A1C is independently associated with severity and prognosis of brainstem infarctions

Cited by 17 publications

References 25 publications

MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes

MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes

Ischemic Volumes and Early Neurologic Deterioration in Acute Brainstem Infarctions with Hemoglobin A<sub>1c</sub>

ISCHEMIC STROKE; FREQUENCY OF RAISED HEMOGLOBIN A1c IN PATIENTS PRESENTING WITH ISCHEMIC STROKE

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