Hemoglobin A1c in predicting progression to diabetes

Nakagami, Tomoko; Tajima, Naoko; Oizumi, Toshihide; Karasawa, Shigeru; Wada, Kiriko; Kameda, Wataru; Susa, Shinji; Kato, Takeshi; Daimon, Makoto

doi:10.1016/j.diabres.2009.11.001

Cited by 26 publications

(22 citation statements)

References 20 publications

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“…Furthermore Japanese studies showed an HbA1c ≥ 5.6% can predict T2DM in the shorter term, similar findings to results from the ARIC and WHS (Nakagami et al, 2010;Inoue et al, 2009;Inoue et al, 2008). A French cohort suggested the same prediction cut-point was from an HbA1c of ≥ 5.7 or 5.8% (Droumaguet et al, 2006).…”

Section: Hba1c To Predict Incident T2dmsupporting

confidence: 71%

“…Six studies were based in Japan (Nakagami et al, 2010;Sato et al, 2009;Inoue et al, 2008;Inoue et al, 2007;Takahashi et al, 2006;Takahashi et al, 2010), five within US (although one study focused on Pima Indians only) (Pradhan et al, 2007;Selvin et al, 2010;Edelman et al, 2004;Little et al, 1994;Selvin et al, 2011), five from Europe (Droumaguet et al, 2006;Norberg et al, 2006;Kolberg et al, 2009;Chamnan et al, 2010;Cederberg et al, 2010) and two studies were conducted in China (Ko et al, 1999;Ko et al, 2000). Data was lacking in Hispanic, African and south Asian populations.…”

Section: Aimsmentioning

confidence: 99%

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Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Davies¹

2012

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BackgroundThe incidence of Type 2 Diabetes Mellitus (T2DM) is increasing rapidly, therefore there is a need to detect this disease earlier and more efficiently, and also to identify novel risk factors that may aid both its detection and prevention.Aims: 1) To discuss the benefits and disadvantages of using HbA1c for diagnosis of T2DM and impaired glucose regulation (IGR).2) To explore the impact on prevalence of using HbA1c to detect T2DM and IGR in global and local populations.3) To determine if diagnostic cut-points are equivalent in different ethnic groups 4) To determine the use of the triglyceride-to-HDL ratio and its association with insulin resistance and whether statins and liver enzymes predict T2DM. 5) To investigate if Vitamin D deficiency has a role in the prevention of T2DM by designing a 6 month randomised controlled trial on vitamin D replacement.Key findings: 1) Using HbA1c for diagnosis has some logistical advantages over glucose testing, but may not detect the same people as having T2DM or IGR.2) In Leicestershire, using HbA1c will increase numbers of people with T2DM and IGR. On global level, there will be regional variation on the effect on prevalence.3) HbA1c, fasting and two hour plasma glucose are independently higher in South Asians (SA). Complications of T2DM may begin earlier in SA.4) The triglyceride-to-HDL ratio associates with insulin resistance in Europeans and SA men but not women. Statin therapy reduces the risk of incident T2DM.Liver enzymes predict T2DM in Europeans but not SA.

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Section: Hba1c To Predict Incident T2dmsupporting

confidence: 71%

Section: Aimsmentioning

confidence: 99%

Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Davies¹

2012

http://isrctn.org/>

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“…In these studies the criterion for diagnosis of diabetes was an FPG value ≥ 7.0 mmol/L or diagnosis by physician. In a study based on the data obtained in the Funagata study, the optimal FPG cut-off value for IFG was found to be 5.36 mmol/L (96 or 97 mg/dL) [16]. In this study the diagnosis of diabetes was based on the results of an OGTT, and the diagnosis of diabetes may be more accurate than in the two previous Japanese studies, but the optimal FPG cut-off value was almost the same.…”

Section: Figmentioning

confidence: 81%

“…Several papers which investigated the IFG cutoff value on the basis of diabetes incidence among Japanese have been published recently [14][15][16]. In a study based on the health checkup data of 11,129 subjects, the optimal FPG cut-off value for IFG was determined to be 5.7 mmol/L (102 or 103 mg/dL) [14].…”

Section: Figmentioning

confidence: 99%

“…Since the findings in the DECODA study also suggested that diagnosis of IGR on basis of FPG values alone (110-125 mg/dL) would underestimate the prevalence of IGR in Asian ethnic groups [13], revision of the FPG cut-off value for Japanese would be considered to establish an effective screening method for IGR. Several papers which investigated the FPG cut-off value on the basis of diabetes incidence among Japanese have been published recently [14][15][16]. In this study we analyzed the relationship between the subjects' FPG values at baseline and the incident diabetes at the time of the 5-year follow-up survey, and attempted to identify the optimal FPG cut-off value for predicting future diabetes in a population-based Japanese cohort.…”

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confidence: 99%

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Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study - suggestion for the threshold for impaired fasting glucose among Japanese

et al. 2010

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ImpaIred glucose regulation (IGR) is a risk factor for both developing diabetes mellitus and coronary heart disease (CHD) [1][2][3]. Based on World Health Organization (WHO) 1999 criteria for diabetes, the DECODE Study Group demonstrated that impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are both associated with an increased incidence of CHD and increased total mortality; and the multivariate-adjusted analysis showed that IGT is an indeFasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study -suggestion for the threshold for impaired fasting glucose among Japanese To determine the optimal fasting plasma glucose (FPG) cut-off value which effectively identifies high risk subjects for type 2 diabetes in Japanese, we conducted a population-based prospective study on diabetes as part of the Japan Public Health Center-based Prospective Study and estimated the 5-year incidence of diabetes. The subjects of the analysis of this study were 2,207 Japanese aged 51-70 at baseline from whom a fasting blood sample was collected in both the baseline and the 5-year follow-up surveys and who completed the questionnaires at both times. Diabetes was defined as an FPG value ≥ 126 mg/dL (7.0 mmol/L) and/or self-reported diabetes. A total of 125 subjects developed diabetes during the 5 years after the baseline survey, and the incidence rate for a baseline FPG value of 95-99, 100-104, 105-109, 110-114, 115-119, and 120-125 mg/dL was 6.1, 11.5, 30.3, 52.6, 86.4, and 115.2 per 1,000 person-years, respectively. The results of receiver operating characteristic curve analysis suggested that an FPG value of 102 mg/dL (5.67 mmol/L) was optimal for predicting diabetes during the next 5-years. The cut-off value was similar in both genders and in the 51-to 60-year-old group and 61-to 70-year-old group. Use of hemoglobin A 1c level ≥ 6.1% for an additional diagnostic criterion resulted in a small increment in incidence, but the cut-off value for predicting diabetes was almost the same (101 mg/dL). The results of this study suggested that the cut-off FPG value should be lowered in terms of prediction of type 2 diabetes among Japanese populations.

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Current literature in diabetes

2010

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Hemoglobin A1c in predicting progression to diabetes

Cited by 26 publications

References 20 publications

Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Can vitamin D replacement reduce insulin resistance in South Asians with vitamin D deficiency?

Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study - suggestion for the threshold for impaired fasting glucose among Japanese

Current literature in diabetes

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