Hemodynamics in a Lethal Basilar Artery Aneurysm Just before Its Rupture

Abstract

BACKGROUND AND PURPOSE:Hemodynamics is thought to play an important role in the mechanisms of cerebral aneurysm initiation, progression, and rupture. The purpose of this study was to present a hemodynamic study of a cerebral aneurysm immediately before its rupture to assess whether previously identified hemodynamic characteristics would classify this aneurysm in the high-risk category.

Analysis of Morphologic and Hemodynamic Parameters for Unruptured Posterior Communicating Artery Aneurysms with Oculomotor Nerve Palsy

“…Accordingly, the best way to evaluate the rupture risk of IA is to study the aneurysm in the ready-to-rupture state. A few cases of gross blood-flow characteristics of IA just before rupture have been reported, 14,15 but without comparison with ruptured aneurysms. The exact morphology and hemodynamics just before aneurysm rupture are not clear yet, but both studies of aneurysms before their rupture demonstrated low WSS on the aneurysm sacs.…”

Wall Shear Stress and Pressure Distribution on Aneurysms and Infundibulae in the Posterior Communicating Artery Bifurcation

“…7,8,44,52,56 Impinging zones and areas of high WSS were correlated to aneurysm rupture. 5 The histological study of Meng et al 32 also shows that destructive remodeling involving loss of smooth muscle cells occurs at the region of high WSS and WSS gradient, where the flow accelerates near the impinging area. Therefore, we examine the flow pattern in the infundibulae, WSS/pressure distributions in the PCoA region, and the effect of widened root of a branch on the impinging patten using patient-specific infundibulum and aneurysm geometries.…”

Patient-Specific Computational Hemodynamics of Intracranial Aneurysms from 3D Rotational Angiography and CT Angiography: An In Vivo Reproducibility Study

“…[2][3][4] CFD simulations have been used to gain insight into the patient-specific hemodynamics and could potentially assist rupture-risk assessment [5][6][7][8][9] and treatment planning. [10][11][12][13][14][15][16] Vascular models can be constructed through segmentation of 3DRA and CTA images.…”