Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review

Hsu, Steven; Fang, James C.; Borlaug, Barry A.

doi:10.1016/j.cardfail.2021.07.012

Cited by 53 publications

(59 citation statements)

References 89 publications

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“…Exercise and drug loading examinations were not performed. Marked hemodynamic change occurs during exercise; therefore, the right atrial pressure waveform may change because the assessment of RV distensibility judged by the right atrial pressure waveform is influenced by RV systolic function, relaxation ability, and RV preload and afterload ( 3 ). As LV pressure was not examined in this study, the impact of LV diastolic dysfunction on RV diastolic function, i.e., inter-ventricular interaction, is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Right ventricular (RV) function affects the severity of heart failure independently of left ventricular (LV) systolic function ( 1 ). The right ventricle is characterized by higher compliance than the left ventricle, and the diastolic function of the right ventricle is superior to that of the left ventricle ( 2 , 3 ). Therefore, RV diastolic function plays an important role in hemodynamics, and the function should be examined to consider the therapeutic strategies for patients with heart failure.…”

Section: Introductionmentioning

confidence: 99%

“…One is the right-sided shift of the RV diastolic pressure-volume curve and volume overload, and the representative disease is tricuspid regurgitation. The other is an upward shift of the RV diastolic pressure-volume curve and restriction filling, and representative diseases are restrictive cardiomyopathy and constrictive pericarditis ( 3 , 6 , 7 ). These changes reduce the reserve function of RV distensibility or less-distensible right ventricle.…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Deep Y Descent on Hemodynamics in Patients With Heart Failure and Preserved Left Ventricular Systolic Function

Harada

Asanoi

Noto

et al. 2021

Front. Cardiovasc. Med.

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Background: Influence of right ventricular diastolic function on the hemodynamics of heart failure (HF). We aimed to clarify the hemodynamic features of deep Y descent in the right atrial pressure waveform in patients with HF and preserved left ventricular systolic function.Methods: In total, 114 consecutive inpatients with HF who had preserved left ventricular systolic function (left ventricular ejection fraction ≥ 50%) and right heart catheterization were retrospectively enrolled in this study. The patients were divided into two groups according to right atrial pressure waveform, and those with Y descent deeper than X descent in the right atrial pressure waveform were assigned to the deep Y descent group. We enrolled another seven patients (two men, five women; mean age, 87 ± 6) with HF and preserved ejection fraction, and implanted a pacemaker to validate the results of this study.Results: The patients with deep Y descent had a higher rate of atrial fibrillation, higher right atrial pressure and mean pulmonary arterial pressure, and lower stroke volume and cardiac index than those with normal Y descent (76 vs. 7% p < 0.001, median 8 vs. 5 mmHg p = 0.001, median 24 vs. 21 mmHg p = 0.036, median 33 vs. 43 ml/m2p < 0.001, median 2.2 vs. 2.7 L/m2, p < 0.001). Multiple linear regression revealed a negative correlation between stroke volume index and pulmonary vascular resistance index (wood unit*m2) only in the patients with deep Y descent (estimated regression coefficient: −1.281, p = 0.022). A positive correlation was also observed between cardiac index and heart rate in this group (r = 0.321, p = 0.038). In the other seven patients, increasing the heart rate (from median 60 to 80/min, p = 0.001) significantly reduced the level of BNP (from median 419 to 335 pg/ml, p = 0.005).Conclusions: The hemodynamics of patients with HF with deep Y descent and preserved left ventricular systolic function resembled right ventricular restrictive physiology. Optimizing the heart rate may improve hemodynamics in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Deep Y Descent on Hemodynamics in Patients With Heart Failure and Preserved Left Ventricular Systolic Function

Harada

Asanoi

Noto

et al. 2021

Front. Cardiovasc. Med.

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show abstract

“…Estudios recientes han demostrado que estos pacientes poseen peor pronóstico clínico; no obstante, el diagnóstico temprano e inicio precoz de tratamiento puede mejorar la sobrevida (1) .…”

Section: Hipertensión Pulmonarunclassified

“…El primer cateterismo cardíaco fue realizado en 1920 por el doctor Werner Forssmann a través de la introducción de una sonda urológica en la vena antecubital hasta la aurícula derecha (1) .…”

Section: Introductionunclassified

Monitoreo hemodinámico invasivo por catéter de arteria pulmonar Swan-Ganz: conceptos y utilidad

Rueda¹,

Gonzalez²,

Cachi³

et al. 2021

Arch Peru Cardiol Cir Cardiovasc

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Desde sus inicios en el siglo pasado, el cateterismo de arteria pulmonar (CAP) ha ido evolucionando hasta ser una técnica de evaluación hemodinámica invasiva que puede realizarse en la cama del paciente a través de un catéter Swan-Ganz; este procedimiento ha mantenido un curso intermitente en cuanto a su uso; no obstante, actualmente ha demostrado relevancia en escenarios específicos. El CAP permite el acceso a la circulación venosa central, el corazón derecho y la arteria pulmonar; realiza el cálculo de variables hemodinámicas de manera directa o indirecta mediante fórmulas y métodos establecidos. Esto hace posible realizar una evaluación y clasificación hemodinámica adecuada, realizar pruebas específicas (p. ej. prueba de vasorreactividad), que ayudan a definir el diagnóstico, la conducta terapéutica, monitorizar la respuesta al tratamiento, la evaluación previa a terapias avanzadas (p. ej. el trasplante cardiaco o dispositivos de asistencia circulatoria mecánica), y el pronóstico en los pacientes. En este artículo profundizamos sobre los conceptos y la utilidad del cateter de arteria pulmonar.

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2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Hu,

Feng,

Yang

2024

Adv Funct Materials

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Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority in deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration due to their low biotoxicity, high biocompatibility, rapid clearance, and good modification properties. As the key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role in the construction of donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes the research development of NIR‐II small molecule fluorophores based on BTD derivatives in the field of bioimaging, focusing on molecular design and photophysical properties, and introduces a part of the applications in the biological field. Furthermore, the challenges of BTD‐based NIR‐II fluorophores in the future development and application are discussed .

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Hemodynamics for the Heart Failure Clinician: A State-of-the-Art Review

Cited by 53 publications

References 89 publications

The Impact of Deep Y Descent on Hemodynamics in Patients With Heart Failure and Preserved Left Ventricular Systolic Function

The Impact of Deep Y Descent on Hemodynamics in Patients With Heart Failure and Preserved Left Ventricular Systolic Function

Monitoreo hemodinámico invasivo por catéter de arteria pulmonar Swan-Ganz: conceptos y utilidad

2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

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