Hemodynamics During Development and Postnatal Life

Sedmera, David

doi:10.1007/978-3-7091-1883-2_9

Cited by 2 publications

(1 citation statement)

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“…Изменение в дальнейшем формы сердца до вида "изогнутой трубки" сопровождается не только переменой типа движений, приближающихся к образцу скручивающейся модели, но и постепенным возрастанием скорости распространения импульсов с последующим изменением характера электромеханической активации к последовательности, встречающейся в зрелой модели, -от "верхушки к основанию" [20,32]. Возникающий в данных условиях внутриутробный поток влияет на эмбриональное развитие сердца через трансдукцию сил сдвига на эндотелиальные слои [32]. Изменения картины течения вызывают макроскопические трансформации геометрии сердца, поскольку формирование вихревого кольца обеспечивает стабильное, повторяющееся и предсказуемое движение потока, регулирующего и оптимизирующего кардиогенез [22,33].…”

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Child’s heart development and contractility from prenatal to postnatal period

et al. 2022

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This literature review analyzes current data on the main stages of child’s heart contractility development from prenatal to postnatal period. The presented information will expand the conventional ideas on the age-related cardiovascular physiology in children, supplementing with relevant knowledge about the patterns of left ventricular mechanics, and the mechanisms affecting child’s heart morphology. In addition, we consider the evolutionary feasibility of the simultaneous existence of various left ventricular mechanics models, which ensure the effective cardiac function in the postnatal period. This is very important for the work of neonatologists, pediatricians, pediatric cardiologists and therapists.

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Child’s heart development and contractility from prenatal to postnatal period

et al. 2022

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Cardiac Enlargement in the Chick Embryo Induced by Hypothermic Incubation Is Due to a Combination of Hyperplasia and Hypertrophy of Cardiomyocytes

Skuhrová,

Kvasilová,

Svatůňková

et al. 2019

Fol. Biol.

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Hypothermic incubation of chicken eggs leads to smaller embryos with enlarged hearts, originally described as hypertrophic. Over the years, however, accumulated evidence suggested that hyperplasia, rather than hypertrophy, is the predominant mechanism of cardiac growth during the prenatal period. We have thus set to re-evaluate the hypothermia model to precise the exact cellular mechanism behind cardiac enlargement. Fertilized chicken eggs were incubated at either 37.5 °C (normothermia) or 33.5 °C from embryonic day (ED) 13 onward (hypothermia). Sampling was performed at ED17, at which point wet embryo and heart weight were recorded, and the hearts were submitted to histological examination. In agreement with previous results, the hypothermic embryos were 29% smaller and had hearts 18% larger, translating into a 67% increase in the heart to body weight ratio (P < 0.05 for all parameters). The cell size was essentially the same between control and hypothermic hearts in all regions analysed. Likewise, there was no significant relationship between the cell size and heart weight; however, in the hypothermic hearts, there was a trend showing positive correlation between cell sizes in different cardiac regions and heart weight. Proliferation rate, determined on the basis of anti-phosphohistone H3 immunofluorescence, showed an overall increase in the hypothermic group, reaching statistical significance (P = 0.02, t-test) in the right ventricle. The proliferation rate was similar among different regions of the same heart. However, the correlation between the proliferation rate and heart weight was only small (r2 = 0.007 and r2 = 0.234 for the normothermic and hypothermic group, respectively). We thus conclude that hyperplasia is the predominant response mechanism in this volume-overload model; mechanistically, decreased heart rate at lower temperature increases the end-diastolic and stroke volume, minimizing the drop in cardiac output through the Frank- Starling mechanism.

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Hemodynamics During Development and Postnatal Life

Cited by 2 publications

References 46 publications

Child’s heart development and contractility from prenatal to postnatal period

Child’s heart development and contractility from prenatal to postnatal period

Cardiac Enlargement in the Chick Embryo Induced by Hypothermic Incubation Is Due to a Combination of Hyperplasia and Hypertrophy of Cardiomyocytes

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