Hemodynamics and Heart Failure

Ledley, Gary S.; Ahmed, Sibtain; Jones, Haile A; Rough, Steven J.; Kurnik, Peter B.

doi:10.1007/978-1-4471-4219-5_2

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…The latter is a multiorgan syndrome with a net outcome of a failing heart, characterized by a reduced cardiac output and increased venous pressure. 64 Coronary arteriosclerosis contributes to CHF, but any sustained myocardial stress such as increased cardiac pressure and volume overload may lead to myocardial hypertrophic response and cardiac remodeling, eventually resulting in CHF. 39 Although speculative, the differential results of CHF from CHD/stroke support the possibility that poor olfaction may signal or elevate one's vulnerability to myocardial stressors.…”

Section: Discussionmentioning

confidence: 99%

Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults

Chamberlin,

Yuan,

et al. 2024

JAHA

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Background Olfactory impairment is common in older adults and may be associated with adverse cardiovascular health; however, empirical evidence is sparse. We examined olfaction in relation to the risk of coronary heart disease (CHD), stroke, and congestive heart failure (CHF). Methods and Results This study included 2537 older adults (aged 75.6±2.8 years) from the Health ABC (Health, Aging, and Body Composition) study with olfaction assessed by the 12‐item Brief Smell Identification Test in 1999 to 2000, defined as poor (score ≤8), moderate (9–10), or good (11–12). The outcomes were incident CHD, stroke, and CHF. During up to a 12‐year follow‐up, 353 incident CHD, 258 stroke, and 477 CHF events were identified. Olfaction was statistically significantly associated with incident CHF, but not with CHD or stroke. After adjusting for demographics, risk factors, and biomarkers of CHF, the cause‐specific hazard ratio (HR) of CHF was 1.32 (95% CI, 1.05–1.66) for moderate and 1.28 (95% CI, 1.01–1.64) for poor olfaction. These associations were robust in preplanned subgroup analyses by age, sex, race, and prevalent CHD/stroke. While the subgroup results were not statistically significantly different, the association of olfaction with CHF appeared to be evident among participants who reported very good to excellent health (HR, 1.47 [95% CI, 1.01–2.14] for moderate; and 1.76 [95% CI, 1.20–2.58] for poor olfaction), but not among those with fair to poor self‐reported health (HR, 1.04 [95% CI, 0.64–1.70] for moderate; and 0.92 [95% CI, 0.58–1.47] for poor olfaction). Conclusions In community‐dwelling older adults, a single olfaction test was associated with a long‐term risk for incident CHF, particularly among those reporting very good to excellent health.

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Section: Discussionmentioning

confidence: 99%

Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults

Chamberlin,

Yuan,

et al. 2024

JAHA

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“…In contrast to CHD and ischemic stroke where arterio-and/or atherosclerosis are major mechanisms 39,40 , CHF is etiologically more complex. The latter is a multiorgan syndrome with a net outcome of a failing heart, characterized by a reduced cardiac output and increased venous pressure 41 . Coronary arteriosclerosis contributes to CHF, but any sustained myocardial stress such as increased cardiac pressure and volume overload may lead to myocardial hypertrophic response and cardiac remodeling, eventually resulting in CHF 34 .…”

Section: Discussionmentioning

confidence: 99%

Olfactory impairment and the risk of major adverse cardiovascular outcomes in older adults

Chamberlin,

Yuan,

et al. 2023

Preprint

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Background: Olfactory impairment is common in older adults and may be associated with adverse cardiovascular health; however, empirical evidence is sparse. Objective: To examine olfaction and the risk of coronary heart disease (CHD), stroke, and congestive heart failure (CHF). Methods: This study included 2,537 older adults (aged 75.6±2.8 years) from the Health ABC Study with olfaction assessed by the 12-item Brief Smell Identification Test in 1999-2000, defined as poor (score ≤8), moderate (9-10), or good (11-12). The outcomes were incident CHD, stroke, and CHF. Results: During up to 12-year follow-up, 353 incident CHD, 258 stroke, and 477 CHF events were identified. Olfaction was associated with incident CHF, but not with CHD or stroke. After adjusting for demographics, the cause-specific hazard ratio (HR) of CHF was 1.35 (95% confidence interval (CI): 1.08, 1.70) for moderate and 1.39 (95%CI: 1.09, 1.76) for poor olfaction. With additional adjustment for lifestyle, chronic diseases, and biomarkers of CHF, the HR was modestly attenuated to 1.32 (95%CI: 1.05, 1.66) for moderate and 1.28 (95%CI: 1.01, 1.64) for poor olfaction. These associations were robust in pre-planned subgroup analyses by age, sex, race, and prevalent CHD/stroke. However, the associations appeared to be evident among participants who reported very-good-to-excellent health (HR=1.47 (95%CI: 1.02, 2.13) for moderate and 1.76, (95%CI: 1.20, 2.57) for poor olfaction). In contrast, null association with CHF was found among those with fair-to-poor self-reported health. Conclusions: In community-dwelling older adults, a single olfaction test was associated with a long-term risk for incident CHF, particularly among those reporting very-good-to-excellent health.

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Hemodynamics and Heart Failure

Cited by 2 publications

References 20 publications

Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults

Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults

Olfactory impairment and the risk of major adverse cardiovascular outcomes in older adults

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