Hemodynamics and Arterial Properties in Response to Mental Stress in Individuals with Mild Hypertension

Tsai, Pei Shan; Yucha, Carolyn B.; Nichols, Wilmer W.; Yarandi, Hossein

doi:10.1097/01.psy.0000074758.02451.76

Cited by 16 publications

(25 citation statements)

References 34 publications

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“…Overall, the laboratory task used in this investigation was associated with increased cardiovascular functioning (i.e., blood pressure, pulse rate, and vascular resistance) in both boys and girls. Consistent with Tsai et al [39], who examined hemodynamic and arterial properties associated with mental stress in normotensives and mild hypertensives, this task was also related to a statistically significant decrease in arterial elasticity among boys in the present study. Future studies should explore the possible mitigating effects of sex steroids on the association between gender and task-induced changes in LAE.…”

Section: Discussionsupporting

confidence: 93%

Large Arterial Elasticity Varies as a Function of Gender and Racism-Related Vigilance in Black Youth

Clark

Benkert

Flack

2006

Journal of Adolescent Health

115

116

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Section: Discussionsupporting

confidence: 93%

Large Arterial Elasticity Varies as a Function of Gender and Racism-Related Vigilance in Black Youth

Clark

Benkert

Flack

2006

Journal of Adolescent Health

115

116

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“…Previous results have been equivocal, with reports of both similar (Tsai et al . ; Khan et al . ) and exaggerated (Kohler et al .…”

Section: Discussionmentioning

confidence: 99%

Neurovascular mechanisms underlying augmented cold‐induced reflex cutaneous vasoconstriction in human hypertension

Greaney

Kenney

Alexander

2017

The Journal of Physiology

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Despite ample evidence of dysregulated sympathetic control of the peripheral vasculature in hypertension, no studies have examined integrated neurovascular function during cold stress in hypertensive adults (HTN). We hypothesized that (i) whole-body cooling would elicit greater cutaneous vasoconstriction and greater increases in skin sympathetic nervous system activity (SSNA) in HTN (n = 14; 56 ± 2 years) compared to age-matched normotensive adults (NTN; n = 14; 55 ± 2 years) and (ii) augmented reflex vasoconstriction in HTN would be mediated by an increase in cutaneous vascular adrenergic sensitivity and a greater contribution of non-adrenergic sympathetic co-transmitters. SSNA (peroneal microneurography) and red cell flux (laser Doppler flowmetry; dorsum of foot) were measured during whole-body cooling (water-perfused suit). Sympathetic adrenergic- and non-adrenergic-dependent contributions to reflex cutaneous vasoconstriction and vascular adrenergic sensitivity were assessed pharmacologically using intradermal microdialysis. Cooling elicited greater increases in SSNA (NTN: +64 ± 13% vs. HTN: +194 ± 26% ; P < 0.01) and greater reductions in skin blood flow (NTN: -16 ± 2% vs. HTN: -28 ± 3% ; P < 0.01) in HTN compared to NTN, reflecting an increased response range for sympathetic reflex control of cutaneous vasoconstriction in HTN. Norepinephrine dose-response curves showed no HTN-related difference in cutaneous adrenergic sensitivity (logEC ; NTN: -7.4 ± 0.3 log M vs. HTN: -7.5 ± 0.3 log M; P = 0.84); however, non-adrenergic sympathetic co-transmitters mediated a significant portion of the vasoconstrictor response to cold stress in HTN. Collectively, these findings indicate that hypertension increases the peripheral cutaneous vasoconstrictor response to cold via greater increases in skin sympathetic outflow coupled with an increased reliance on non-adrenergic neurotransmitters.

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“…This may suggest that subjects with hypertension are highly susceptible to noise exposure perhaps due to instability of blood pressure when exposed to exogenous stimuli, including noise exposure. Various studies have suggested that subjects with hypertension have exaggerated blood pressure reactivity to stress compared with normotensives [25][26][27][28][29] . In addition, a study reported that the excess mortality from coronary heart disease and stroke associated with mental stress tended to be more evident among those with hypertension who may have more advanced atherosclerosis compared with those with normal blood pressure 12) .…”

Section: Discussionmentioning

confidence: 99%

A Prospective Cohort Study of Perceived Noise Exposure at Work and Cerebrovascular Diseases among Male Workers in Japan

Fujino

Iso

Tamakoshi³

2007

Journal of Occupational Health

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A Prospective Cohort Study of Perceived Noise Exposure at Work and Cerebrovascular Diseases among Male Workers in Japan: Yoshihisa FUJINO, et al. Department of Preventive Medicine andCommunity Health, University of Occupational and Environmental Health, Japan -This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death were identified from death certificates. The analysis was restricted to 14,568 men free of a cerebrovascular diseases (age range: 40-59 yr) who were in work at the time of the baseline survey. All subjects completed a self-administered questionnaire at the baseline. This included a question regarding perceived noise exposure at work. The Cox proportional-hazards model was used to estimate the risks of perceived noise exposure for death due to cerebrovascular diseases. The model included age, smoking, alcohol consumption, educational level, perceived mental stress, past medical history, body mass index, hours of walking, hours of exercise, shift work, and job type. During the 190,777 person-years of follow-up, a total of 1,064 deaths were recorded, 98 from cerebrovascular diseases, 27 deaths from subarachnoid haemorrhage, 35 deaths from intracerebral haemorrhage, and 25 deaths from cerebral infarction. Noise exposure did not increase the risk of cerebrovascular diseases, subarachnoid haemorrhage, or cerebral infarction. However, perceived noise exposure increased the risk of intracerebral haemorrhage diseases (hazard ratio (HR) =2.38, 95%CI: 1.20, 4.71, p=0.013). Furthermore, individuals with hypertension were highly susceptible to the effect of perceived noise exposure on the risk of intracerebral hemorrhage, but this association was not observed among the subjects without hypertension. Although the underlying mechanisms are not clear, hypertensive individuals with perceived noise exposure at work should be regarded as a high-risk group for intracerebral hemorrhage. (J Occup Health 2007; 49: 382-388)

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Hemodynamics and Arterial Properties in Response to Mental Stress in Individuals with Mild Hypertension

Cited by 16 publications

References 34 publications

Large Arterial Elasticity Varies as a Function of Gender and Racism-Related Vigilance in Black Youth

Large Arterial Elasticity Varies as a Function of Gender and Racism-Related Vigilance in Black Youth

Neurovascular mechanisms underlying augmented cold‐induced reflex cutaneous vasoconstriction in human hypertension

A Prospective Cohort Study of Perceived Noise Exposure at Work and Cerebrovascular Diseases among Male Workers in Japan

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