Hemodynamic responses of isolated cat lungs during forward and retrograde perfusion.

Donor pretreatment using the aerosolized prostacyclin analogue iloprost optimizes post-ischemic function of non-heart beating donor lungs

“…4,28,29 Recently, the innovative approach of retrograde preservation of lung grafts has been shown to be very effective in elimination of different kinds of thrombi from the pulmonary vasculature in combination with a significantly improved preservation quality. 6,29 -32 This phenomenon is believed to be due to the more homogeneous distribution in the low-pressure, high-capacity pulmonary venous system [33][34][35] and the concomitant preservation of small but important bronchial circulation. 36 -38 Therefore, because some institutions have already adopted this innovative approach into clinical practice, 27,39 we decided to use retrograde preservation for all transplantation experiments in this study in order to address the special problems of non-heart-beating donor organ preservation in terms of intravascular thrombosis being as optimal as possible.…”

Experimental Lung Transplantation: Impact of Preservation Solution and Route of Delivery

“…19 -23 A recently described new approach to further enhance the uniformity of distribution of preservation solutions involves use of "retrograde pulmonoplegia" through the left atrium into the pulmonary venous system, which is characterized by a low vascular resistance and a high volume capacity. 24,25 Due to these characteristics, a rapid and homogeneous distribution of preservation solutions can be achieved. 26,27 Furthermore, retrograde preservation through the pulmonary veins can flush both the pulmonary and especially the bronchial circulation, which is considered to be a vital part of organ blood supply.…”

Pulmonary Arterial Wedge and Left Atrial Pressures and the Site of Hypoxic Pulmonary Vasoconstriction

“…These workers noted constriction of pulmonary arteries larger than 2 mm in diameter. Studies on isolated perfused lungs using the retrograde and forward perfusion technique have also provided evidence for a primarily arterial site of action for hypoxia [1,2,5],…”