Hemodynamic Responses and intubating conditions in laryngeal mask airway insertion a comparative study of propofol versus sevoflurane

Abstract

Background: LMA is an effective alternative to the endotracheal tube for securing the airway in short surgical procedures. Propofol is a widely used anaesthetic agent for the insertion of Laryngeal Mask Airway. Sevoflurane is a volatile anaesthetic agent, which combines rapid, smooth inhalational induction of anaesthesia with rapid recovery, making it ideal for day care anaesthesia. Objective: To study if the use of sevoflurane can be used as an alternative to IV propofol for laryngeal mask airway insertion. Primary objective: Hemodynamic responses during Laryngeal mask insertion. Secondary objective: Intubating conditions during laryngeal mask airway insertion. Study design: A Randomized control trial. Methods: 100 adults were allocated by randomization into two groups of 50 each; group P (Propofol) and group S (Sevoflurane). Patients in group P were induced with 2.5mg/kg intravenous propofol with 50% O 2 & 50% N 2 O and in group S with 8% sevoflurane in 50% O 2 & 50% N 2 O vital capacity breath technique. Laryngeal mask airway was inserted after adequate jaw relaxation was attained and hemodynamic responses like pulse rate, blood pressure were monitored. The grading of conditions for laryngeal mask airway insertion and number of attempts were noted. All the data collected was analysed statistically. Results: We observed that more number of attempts were required for LMA insertion in Group S (14.0%) compared to Group P (0.0%) which is statistically significant with P=0.012. Heart rate at one minute and 2 minutes after LMA insertion showed a fall with Propofol which was statistically significant as compared to Sevoflurane. There is a significant difference of fall in mean arterial blood pressure in group P during induction, one minute, 2 minutes and 5 minutes when compared between the two groups. Sevoflurane took longer time for induction and LMA insertion compared to Propofol which is statistically significant. Moderate patient movement were noticed in 5 patients of group S and no patient movement were noticed in group P and is statistically significant (P-0.022). Quality of insertion with propofol was excellent in all patients. With sevoflurane quality of insertion ranged from excellent to satisfactory. Conclusion: Sevoflurane is associated with good hemodynamic stability but intubating conditions provided with propofol is superior. Prolonged time for jaw relaxation with sevoflurane when compared to propofol may delay laryngeal mask airway insertion. Quality of insertion with propofol was excellent in all patients. With sevoflurane quality of insertion ranged from excellent to satisfactory.

Comparison of different induction techniques on hemodynamic changes in pediatric patients undergoing infra umbilical surgeries using laryngeal mask airway

“…The findings indicate that group P observed a decrease in diastolic blood pressure whereas in group S and group SP, no significant change in diastolic blood pressure was observed. Similar to our study, Mathew et al 16 observed a significant drop in diastolic blood pressure in the propofol group when compared with sevoflurane.…”

“…The findings in systolic blood pressure indicate that group P observed a decrease in systolic blood pressure whereas in group S and group SP, no significant change in systolic blood pressure was observed. Similar to our study, Mathew et al 16 observed a drop in systolic blood pressure in group P when compared to group S. Similarly, Vora et al, 18 while comparing sevoflurane and propofol, observed a drop in systolic blood pressure in group P which was more at 2 min post-LMA insertion.…”

“…Sevoflurane mildly depresses myocardial contractility and systemic vascular resistance which leads to a decrease in heart rate. Mathew et al 16 observed a decrease in heart rate in the propofol group at 1 min and 2 min post-induction in comparison with sevoflurane.…”