Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases

Simoes, Giovana M.S.; Campagnaro, Bianca Prandi; Tonini, Clarissa Loureiro; Meyrelles, Silvana S.; Kuniyoshi, Fatima H. Sert; Vasquez, Elisardo C.

doi:10.7150/ijms.5967

Cited by 12 publications

(4 citation statements)

References 51 publications

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“…We cannot offer explanation for decrease in WCT-SI in lean and opposite response in obese. Reactivity to mental and physical stress is shown to be influenced by gender [37]. However, in our study, similar gender distribution in all 3 BMI groups and also repeated measure analyses controlled for age and gender may have nullified the gender effect if any on the reactivity in these 3 groups.…”

Section: Baseline Hemodynamic and Autonomic Parameterscontrasting

confidence: 49%

Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

Jaju¹,

M²,

Malekinejad³

et al. 2016

Journal of Obesity and Overweight

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Obesity is a known risk for cardio-metabolic diseases such as hypertension, ischemic heart disease [1,2], type-2 diabetes mellitus [3] and comorbidities like obstructive sleep apnea [4]. Previous studies showed hemodynamic and autonomic alterations in lean compared to obese [5,6] such as increased resting heart rate (HR), blood pressure (BP) [5,7], muscle sympathetic nerve activity (MSNA) [5,7,8], left ventricular mass index [9] and low frequency spectrum of heart rate variability (HRV) [6]. Contrary to this, autonomic activity was also shown to decrease with obesity [10,11] and had inverse relationship with body fat percentage [1]. AbstractObjective: There could be progressive changes in hemodynamic and autonomic parameters causing cardiovascular damage from lean to morbid obesity. We aim to study resting and reactivity of hemodynamic and autonomic parameters to physical and mental stress in lean, overweight and obese subjects of the Oman Family Study (OFS). Materials and Methods:Normal subjects from OFS, grouped as lean (N=437; Males=194), overweight (N=366; Males=172) and obese (N=214; Males=90) based on WHO classification of BMI underwent impedance cardiography and spectral analysis to estimate hemodynamic and autonomic parameters at rest and during 3min of word conflict test (WCT) and cold pressor test (CPT). Results: At rest, overweight had high BP compared to lean, similar BP in overweight and obese and lowest stroke index (SI) in obese and low power spectral density (P<0.05) in obese compared to overweight. The changes (∆) in HR, mean BP, cardiac and peripheral resistance index were similar in 3 groups during WCT. Autonomic responses to WCT and CPT were similar in 3 groups. Obesity measures (BMI, % fat) showed monotonic correlations with resting hemodynamic and autonomic parameters and with ∆WCT and CPT HR and SI.

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Section: Baseline Hemodynamic and Autonomic Parameterscontrasting

confidence: 49%

Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

Jaju¹,

M²,

Malekinejad³

et al. 2016

Journal of Obesity and Overweight

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“…Sex differences in BP responses during exercise. Females are reported to have lower BP responses compared with males during fixed duration relative-intensity static exercise (9,11,(14)(15)(16)38). Because maximal absolute load (MVC) is inversely related to static endurance (12), normalizing comparisons to a percentage of time to volitional failure has eliminated sex differences in BP responses in some (13,39,40) but not all studies (12,17).…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure Responses to Static and Dynamic Knee Extensor Exercise between Sexes: Role of Absolute Contraction Intensity

Lee

Lutz

Omazic

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose: Males have larger blood pressure (BP) responses to relative-intensity static handgrip exercise compared with females. Controlling for absolute load (maximal voluntary contraction (MVC)) abolishes these differences. Whether similar observations exist during large muscle mass exercise or dynamic contractions, and the mechanisms involved, remains unknown. Methods: BP, heart rate, muscle oxygenation (near-infrared spectroscopy), and rectus femoris EMG were recorded in 28 males and 17 females during 10% and 30% MVC static (120 s) and isokinetic dynamic (180 s; 1:2 work-to-rest ratio; angular velocity, 60°•s −1 ) knee extensor exercise. Static and dynamic exercises were completed on separate visits, in a randomized order. Sex differences were examined with and without statistical adjustment of MVC (ANCOVA). Results: Males had larger systolic BP responses (interaction, P < 0.0001) and muscle deoxygenation (interaction, P < 0.01) than did females during 10% static exercise, with no difference in EMG (interaction, P = 0.67). Peak systolic BP was correlated with MVC (r = 0.55, P = 0. 0001), and adjustment for MVC abolished sex differences in systolic BP (interaction, P = 0.3). BP, heart rate, muscle oxygenation/deoxygenation, and EMG responses were similar between sexes during 30% static exercise (interaction; all, P > 0.2), including following adjustment for MVC (all, P > 0.1). Males had larger systolic BP responses during dynamic exercise at 10% and 30% (interaction; both, P = 0.01), which were abolished after adjustment for MVC (interaction; both, P > 0.08). Systolic BP responses were correlated with absolute MVC and stroke volume responses during 10% (r = 0.31, P = 0.04; r = 0.61, P < 0.0001, respectively) and 30% (r = 0.48, P = 0.001; r = 0.59, P < 0.0001, respectively). Conclusions: Absolute contraction intensity can influence systolic BP responses to 10% but not 30% MVC static, as well as 10% and 30% MVC dynamic knee extensor exercise, and should be considered in cross-sectional comparisons of exercise BP.

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“…The present study, as well as other research [ 9 ], announced a significant relationship between family of cardiovascular diseases and prehypertension risk. Laboratory stressor tests showed that healthy subjects with family history of cardiovascular diseases had a more positive hemodynamic responsiveness to stressor tests [ 72 ]. Our results demonstrated that smokers had 1.67 fold risks in getting prehypertension, while other researchers failed to report a significant relationship [ 31 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for prehypertension and their interactive effect: a cross- sectional survey in China

Song

Xue

Zhao

et al. 2018

BMC Cardiovasc Disord

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BackgroundIndividuals with prehypertension are at higher risk of developing hypertension and cardiovascular diseases, while the interaction between factors may aggravate prehypertension risk. Therefore, this study aimed to evaluate the risk factors for prehypertension in Chinese middle-aged and elderly adults, and explore the potentially interactive effect of evaluated factors.MethodsAll the participants that came from a community based cross-sectional survey were investigated in Bengbu, China, by being interviewed with a questionnaire. Body mass index (BMI), Waist circumference (WC) and lipid accumulation product (LAP) that reflect participants’ obesity were also calculated. In addition, logistic regression model was applied to explore the risk factors of prehypertension, followed by the assessment of the interactive effects between risk factors on prehypertension by the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI).ResultsA total of 1777 participants were enrolled in this study, among which the prevalence of normtension, prehypertension and hypertension were 41.70%, 33.93% and 24.37% respectively. According to the multivariate logistic regression analysis, age (OR: 1.01, 95%CI: 1.00–1.02), smoking (OR: 1.67, 95%CI: 1.22–2.29), family history of cardiovascular diseases (OR: 1.52, 95%CI: 1.14–2.02), general obesity (OR: 1.51, 95%CI: 1.15–1.97) and LAP (OR: 2.58, 95%CI: 1.76–3.80) were all defined as the major factors that significantly related with the risk of prehypertension. When identifying prehypertension risk, the receiver-operating characteristics (ROC) curves (AUC) analysis indicated that LAP performed better than BMI in males (Z = 2.05, P = 0.03) and females (Z = 2.12, P = 0.03), but was superior to WC only in females (Z = 2.43, P = 0.01). What is more, there were significant interactive effects of LAP with family history of cardiovascular diseases (RERI: 1.88, 95%CI: 0.25–3.51; AP: 0.44, 95%CI: 0.20–0.69; SI: 2.37, 95%CI: 1.22–4.60) and smoking (RERI: 1.99, 95%CI: 0.04–3.93; AP: 0.42, 95%CI: 0.17–0.67; SI: 2.16, 95%CI: 1.68–4.00) on prehypertension risk. The value of AP (0.40, 95%CI: 0.03–0.77) also indicated a significant interaction between family history of cardiovascular diseases and smoking on prehypertension.ConclusionPrehypertension is currently prevalent in Chinese adults. This study indicated that age, family history of cardiovascular diseases, smoking, general obesity and LAP were significantly related with prehypertension risk. Furthermore, interactive effects on risk of prehypertension had been demonstrated in this study as well, which would help researchers to build strategy against prehypertension more comprehensively and scientifically.Electronic supplementary materialThe online version of this article (10.1186/s12872-018-0917-y) contains supplementary material, which is available to authorized users.

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Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases

Cited by 12 publications

References 51 publications

Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

Blood Pressure Responses to Static and Dynamic Knee Extensor Exercise between Sexes: Role of Absolute Contraction Intensity

Risk factors for prehypertension and their interactive effect: a cross- sectional survey in China

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