Hemodynamic Profile of Iloprost in Rats, Rabbits and Cats

Haberey, Martin; Loge, O; Maass, B; Ohme, G

doi:10.1007/978-3-642-71499-3_18

Cited by 2 publications

(2 citation statements)

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“…At the later time points after CCI,, the AST activitv was ahout the same in hot ti groups. Treatment of the rats with a nonhypotensive dose of Iloprost [0.1 pg per kg per min (28)] significantly reduced the AST activity after CC1, during the entire period of investigation: 300 to 700 units per liter with Iloprost vs. 2,000 to 3,000 units per liter without Iloprost. Similar observations were made with ALT activity (not shown).…”

Section: E F F E C T O F Iloprost Ccl-induced Release O F Ast Ldh mentioning

confidence: 99%

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

et al. 1989

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In the present study, it was investigated whether the prostacyclin derivative Iloprost would protect hepatocytes against CCl4-induced liver injury and which mechanism(s) of hepatocellular pathogenesis might be affected by it. Rats were treated with a single oral dose of CCl4 (2 ml per kg); Iloprost was infused continuously from 2 to 4 hr before intoxication until killing. The following results were obtained. The CCl4-induced release of AST, lactate dehydrogenase and alkaline phosphatase into the serum was reduced by 50 to 70% in rats treated with doses of 0.1 and 0.5 micrograms Iloprost per kg per min. Infusion of 0.02 and 0.004 micrograms Iloprost per kg per min did not affect the CCl4-induced enzyme release into the blood. CCl4 induced the occurrence of aldehydes (products of lipid peroxidation), which were detected by histochemical and biochemical means. At 12, 48 and 72 hr after CCl4, the aldehyde-positive liver section area was about 58, 69 and 16% in rats treated with CCl4 alone, but only about 18, 13 and less than 1% in rats treated additionally with Iloprost. The aldehyde-positive hepatocytes were located predominantly in the centrilobular zone of the liver. At 24 hr the extent of the aldehyde-positive section area was the same in rats with or without Iloprost treatment (about 90%). Biochemical determination, however, revealed that at this time point the malondialdehyde content after Iloprost in rats was about 70% lower than without Iloprost treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: E F F E C T O F Iloprost Ccl-induced Release O F Ast Ldh mentioning

confidence: 99%

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

et al. 1989

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“…Vascular resistance in lower extremity (13) and mesenteric vessels was lowered and blood fl ow was increased (14) without causing hypotension and tachycardia. İlomedin® shows therapeutic effect in occlusive peripheral artery disease in patients because it causes antiaggregation, vasodilatation, and inhibition of thrombocyte functions in addition to leukocyte adhesion (15).…”

Section: Discussionmentioning

confidence: 99%

Effect of iloprost on erythrocyte deformability in rat’s lower extremity undergoing an ischemia reperfusion injury

Arslan¹,

Dönmez²,

Erer³

et al. 2013

BLL

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Aim: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of iloprost on erythrocyte deformability in the infrarenal aorta of rats undergoing I/R. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into the 3 groups; the randomized control group (group C; n=6), I/R group without iloprost (group I/R; n=6) and I/R group with iloprost -10 mcg.kg -1 , 30 min infusion (group I/R-I; n=6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. Results: The comparisons of the control and I/R-I groups revealed similar results (p=0.951). The values of the IR group were signifi cantly higher than those of the control and IR-I groups (p=0.006, p=0.011, respectively). Conclusion: In our study, we detected the unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood fl ow and hence tissue perfusion in the infrarenal rat aorta. We also found that Iloprost had benefi cial effects by reversing the undesirable effects of I/R (Fig. 1, Ref. 15). Full Text in PDF www.elis.sk.

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Hemodynamic Profile of Iloprost in Rats, Rabbits and Cats

Cited by 2 publications

References 5 publications

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

Effect of iloprost on erythrocyte deformability in rat’s lower extremity undergoing an ischemia reperfusion injury

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