Hemodynamic parameters in hypertensive diabetic patients

Yannoutsos, Alexandra; Ahouah, Mathieu; Tubiana, C. Dreyfuss; Topouchian, Jirar; Touboul, Caroline; Safar, Michel E.; Blacher, Jacques

doi:10.1097/hjh.0000000000000898

Cited by 21 publications

(11 citation statements)

References 29 publications

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“…According to previous studies, we have determined a PWV index based on a theoretical PWV calculated through a linear regression on major factors correlated with aortic stiffness, such as age, gender, mean BP, and HR …”

Section: Discussionmentioning

confidence: 99%

“…Few studies have investigated the different risk factors associated with PWV index . In our study, we constructed a decision tree model, based on data from a cross‐sectional study to investigate the different factors associated with PWV index (positive or negative values).…”

Section: Discussionmentioning

confidence: 99%

“…A nomogram of aortic PWV was constructed, by a linear regression analysis, and previously described; according to the determinants of the PWV, to determine theoretical aortic PWV values based on age, gender (male = 1 and female = 0), mean BP and HR.…”

Section: Methodsmentioning

confidence: 99%

“…Parameters influencing PWV measurement at baseline and during follow-up can be evaluated independently of sex, age, mean BP, and HR. 10 A nomogram of aortic PWV was constructed, by a linear regression analysis, and previously described 10,19,20 ; according to the determinants of the PWV, 21 to determine theoretical aortic PWV values based on age, gender (male = 1 and female = 0), mean BP and HR.…”

Section: Determination Of Pwv Indexmentioning

confidence: 99%

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Application of a decision tree to establish factors associated with a nomogram of aortic stiffness

Vallée¹,

Safar²,

Blacher³

2019

J of Clinical Hypertension

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Aortic stiffness is a marker of vascular aging and may reflect occurrence of cardiovascular (CV) diseases. Aortic pulse wave velocity (PWV), a marker of aortic stiffness, can be measured by applanation tonometry. A nomogram of aortic stiffness was evaluated by the calculation of PWV index. Theoretical PWV can be calculated according to age, gender, mean blood pressure, and heart rate, allowing to form an individual PWV index [(measured PWV – theoretical PWV)/theoretical PWV]. The purpose of the present cross‐sectional study was to investigate the determinants of the PWV index, by applying a decision tree. A cross‐sectional study was conducted from 2012 to 2017, and 597 individuals were included. A training decision tree was constructed based on seventy percent of these subjects (N = 428). The remaining 30% (N = 169) were used as the testing dataset to evaluate the performance of the decision trees. The input variables for the models were clinical and biochemical parameters. The different input variables remained in the model were diabetes, tobacco status, carotid plaque, albuminuria, C‐reactive protein, total cholesterol, BMI, and previous CV diseases. For the validation decision model, the sensitivity, specificity, and accuracy values for identifying the related risk factors of PWV index were 70%, 78%, and 0.73. Since determinants of PWV index were all well‐accepted CV risk factors, a nomogram of aortic stiffness could be considered as an integrator of CV risk factors on their duration of exposure and could be utilized to develop future programs for CV risk assessment and reduction strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Determination Of Pwv Indexmentioning

confidence: 99%

See 2 more Smart Citations

Application of a decision tree to establish factors associated with a nomogram of aortic stiffness

Vallée¹,

Safar²,

Blacher³

2019

J of Clinical Hypertension

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“…HRV is one of the first symptoms of cardiac autonomic neuropathy in diabetes, which is also associated with blood pressure dysregulation and left ventricular hypertrophy [2]. Furthermore, recent studies have also shown increased PPA in type 2 diabetic hypertensive patients [3], suggesting vascular remodeling due to increased arterial stiffness as another possible etiology of HRV. It would be interesting to analyze the influence of obesity on HRV and PPA in diabetic patients.…”

mentioning

confidence: 99%