Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke

Intracranial Pressure and Collateral Blood Flow

“…[13][14][15] These findings have been consistent in experiments in which collateral supply was quantified postmortem (number and diameter of vessels) 13,14 or using functional measurement of tissue perfusion within the watershed region between the ACA and MCA. 15 A distinct advantage of animal studies is that thinning or removal of the skull is possible, and this has allowed direct visualization of leptomeningeal collaterals in vivo. 7,16 These studies suggest that collaterals may have dual roles.…”

Retinal Vessel Pathologies in a Rat Model of Periventricular Leukomalacia: A New Model for Retinopathy of Prematurity?

“…The stronger phenotype in the retina ipsilateral to the UCL is likely due to the transitory ischemia, even though complete absence of perfusion is prevented by collateral vessels. 45 The generally milder phenotype in eyes contralateral to UCL was expected. A similar observation was made in brain hemispheres following UCL and correlated with the death of nerve cells in the ipsilateral hemisphere, while cells in the contralateral hemisphere were almost not affected.…”

Ischemic penumbra as a trigger for intracranial pressure rise – A potential cause for collateral failure and infarct progression?

“…[23][24][25][26] This is generally thought to be due to differences in the residual blood flow to the ischemic brain via the leptomeningeal collateral circulation. 27 We have previously demonstrated that inadvertent occlusion of the AChA, an important internal collateral supply to the MCA results in larger 24-h histological infarct volumes. 8 The current analysis indicates that those animals with patent AChA have a larger penumbra.…”